Phenylpropanoid glycosides from Scrophularia scorodonia: In vitro anti-inflammatory activity

Dı́az-Lanza, Ana Marı́a; Abad, María J. F.; Fernández, L.; Silván, A. M.; Santos, Javier de; Bermejo, Paulina

doi:10.1016/j.lfs.2003.10.008

Cited by 170 publications

(45 citation statements)

References 28 publications

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“…Various biological compounds such as phenolic acids, iridoids, phenylpropanoids, flavonoids, saponins, and terpenoids have been isolated from this genus (5-10). These compounds possess anti-inflammatory, antibacterial, immunomodulatory, cardiovascular, diuretic, molluscicidal, cytotoxic, and antitumor properties (11)(12)(13)(14)(15). In traditional Chinese medicine, extract of S. ningpoensis Hemsl has been used in the treatment of fever, constipation, pharyngitis, and neuritis (16).…”

Section: Introductionmentioning

confidence: 99%

The Seasonal Variations of the Chemical Composition of Essential Oil Obtained From Scrophularia frigida

Asgharian

Afshar

Asnaashari

et al. 2016

Jundishapur J Nat Pharm Prod

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Background: In general, seasonal growing of plants influences chemical composition and biological activities of essential oils. Objectives: Therefore, the aerial parts of Scrophularia frigida (S. frigida) were used in the current study to find seasonal variations in the content and composition of essential oil. Materials and Methods:The oil was extracted by hydro-distillation from two samples collected in different seasons, and analyzed by GC-FID and GC-MS. Results: In total, 18 and 20 components were identified and quantified in the oil of summer and autumn samples representing 97.42% and 94.77% of the oil components, respectively. The essential oil of autumn sample was mainly composed of fatty acid derivatives (42.69%). The major components of the autumn oil were palmitic acid (30.49%), phytol (12.99%), L-linalool (11.41%), and hexahydrofarnesyl acetone (6.65%). The essential oil of summer sample was dominated by oxygenated monoterpenes (68.91%), L-linalool (38.69%), geraniol (11.20%), α-terpineol (9.99%), and palmitic acid (7.32%). Conclusions: Based on these observations, wide variation is detected in the chemical composition of the oil obtained from the same plant in different seasons.

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Section: Introductionmentioning

confidence: 99%

The Seasonal Variations of the Chemical Composition of Essential Oil Obtained From Scrophularia frigida

Asgharian

Afshar

Asnaashari

et al. 2016

Jundishapur J Nat Pharm Prod

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“…Consequently, these compositions especially in high value with synergistic effect on cardiac function not only induced no improvement in factors under our investigation, but also developed adverse effects such as arrhythmia. Whereas this plant and other species of this plant contain phenylethanoid and irioid [26][27][28] and cardiac effects of these compounds have already been demonstrated. 7,11,12,28,29 Besides, our previous study showed remarkable cardiovascular effect of S. frigida on isolated rat heart.…”

Section: Discussionmentioning

confidence: 93%

“…Whereas this plant and other species of this plant contain phenylethanoid and irioid [26][27][28] and cardiac effects of these compounds have already been demonstrated. 7,11,12,28,29 Besides, our previous study showed remarkable cardiovascular effect of S. frigida on isolated rat heart. 21 Even though, S .frigida showed significant cardioprotective effects, S. subaphylla indicated no efficacy.…”

Section: Discussionmentioning

confidence: 93%

Effect of Methanolic Extract of Scrophularia subuphylla on Ischemia and Reperfusion-Induced Myocardial Injury

Vaez¹,

Garjani²,

Delazar³

et al. 2018

Pharm Sci

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“…The major bioactive components of S. ningpoensis have been reported to be harpagoside, angoroside C, acteoside, and cinnamic acid (Liu et al, 1995;Miyazawa et al, 1998;de Santos Galíndez et al, 2002;Díaz et al, 2004). However, determined by bioactive components, the quality and efficacy of CMM depend significantly on its geographical origin (Woo et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Molecular authentication of geo-authentic Scrophularia ningpoensis

Chen

Duan

Zhou³

et al. 2011

J. Zhejiang Univ. Sci. B

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Scrophularia ningpoensis has long been used in the Chinese Materia Medica for inflammation. Like other herbal medicines, S. ningpoensis collected from different localities may considerably differ in their therapeutic efficacy, and the one grown in Zhejiang Province is recognized as geo-authentic. However, it is difficult to confirm the geographical authenticity by similar morphological characteristics. In the present study, inter-simple sequence repeat (ISSR) markers were conducted to detect S. ningpoensis from different origins. A 1 259-bp fragment amplified by primer UBC874 was found only in geo-authentic ones. By cloning and sequencing that specific band, sequence characterized amplified region (SCAR) markers were designed to distinguish geo-authentic S. ningpoensis from others. This is a rapid and easy method that can be used to identify the geographical authenticity of S. ningpoensis.

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Phenylpropanoid glycosides from Scrophularia scorodonia: In vitro anti-inflammatory activity

Cited by 170 publications

References 28 publications

The Seasonal Variations of the Chemical Composition of Essential Oil Obtained From Scrophularia frigida

The Seasonal Variations of the Chemical Composition of Essential Oil Obtained From Scrophularia frigida

Effect of Methanolic Extract of Scrophularia subuphylla on Ischemia and Reperfusion-Induced Myocardial Injury

Molecular authentication of geo-authentic Scrophularia ningpoensis

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