Phenytoin-associated vasculitis and ANCA positivity: a case report

Parry, R. G.; Gordon, P; Mason, Justin C.; Marley, N. J. E.

doi:10.1093/oxfordjournals.ndt.a027268

Cited by 19 publications

(15 citation statements)

References 3 publications

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“…Both isoniazid and rifampin have been implicated as causes of vasculitis in case reports (60,61), but the association between these drugs and AAV is confounded by studies that have shown a high prevalence of positive ANCA serologies in patients with tuberculosis (62). Evidence for the association of other medications and AAV is limited to isolated case reports (63)(64)(65).…”

Section: Drugs Associated With Aavmentioning

confidence: 99%

Drug-Induced Glomerular Disease

Hogan

Markowitz²,

Radhakrishnan

2015

Clinical Journal of the American Society of Nephrology

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Drug-induced autoimmune disease was initially described decades ago, with reports of vasculitis and a lupus-like syndrome in patients taking hydralazine, procainamide, and sulfadiazine. Over the years, multiple other agents have been linked to immune-mediated glomerular disease, often with associated autoantibody formation. Certain clinical and laboratory features may distinguish these entities from their idiopathic counterparts, and making this distinction is important in the diagnosis and management of these patients. Here, drug-induced, ANCA-associated vasculitis, drug-induced lupus, and drug-associated membranous nephropathy are reviewed.

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Section: Drugs Associated With Aavmentioning

confidence: 99%

Drug-Induced Glomerular Disease

Hogan

Markowitz²,

Radhakrishnan

2015

Clinical Journal of the American Society of Nephrology

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“…The 2 drugs that have been most often implicated in the induction of APV are hydralazine and propylthiouracil (1)(2)(3)(4)(5). In addition, there have been cases linked to other drugs, including minocycline, sulfasalazine, and penicillamine (2,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Drugassociated APV can result in the same life-threatening vasculitic features as observed in idiopathic cases (1).…”

mentioning

confidence: 99%

Evaluation of antineutrophil cytoplasmic antibody seroconversion induced by minocycline, sulfasalazine, or penicillamine

Choi

Slot²,

Pan

et al. 2000

Arthritis & Rheumatism

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“…Antitubular basement membrane antibodies and phenytoin as an antigen were detected [14][15][16][17][18]. Recently, a phenytoininduced antineutrophil cytoplasm antibody (ANCA)-associated vasculitis was described [19]. In our patient, resolution of the renal failure occurred before and was completed after cessation of phenytoin.…”

Section: Discussionmentioning

confidence: 58%

Early-onset phenytoin toxicity mimicking a renopulmonary syndrome

Polman¹,

Werf²,

Tiebosch³

et al. 1998

Eur Respir J

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Phenytoin is a commonly used anti-epileptic drug. Adverse reactions including fever, skin reactions and lymphadenopathy are well known but atypical reactions can also occur. A patient is described with a lag time of only 4 days between onset of phenytoin and the development of a syndrome with acute lung injury and renal failure. The symptoms mimicked a renopulmonary syndrome, and resolved completely after cessation of phenytoin and addition of steroids.

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Phenytoin-associated vasculitis and ANCA positivity: a case report

Cited by 19 publications

References 3 publications

Drug-Induced Glomerular Disease

Drug-Induced Glomerular Disease

Evaluation of antineutrophil cytoplasmic antibody seroconversion induced by minocycline, sulfasalazine, or penicillamine

Early-onset phenytoin toxicity mimicking a renopulmonary syndrome

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