Phorbaketals L–N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas

Lee, Yehee; Wang, Weihong; Kim, Hiyoung; Giri, Awadut G.; Won, Dong Hwan; Hahn, Dongyup; Baek, Kyung Ryul; Lee, Jihye; Yang, Inho; Choi, Hyukjae; Nam, Sang Jip; Kang, Heonjoong

doi:10.1016/j.bmcl.2014.07.066

Cited by 24 publications

(11 citation statements)

References 17 publications

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“…The new sesterterpenoid phobaketals N ( 326 ) ( Figure 61 ) isolated from a Korean Phorbas sp. sponge has potent cytotoxicity against the human pancreas cell line (Panc-1) and the human renal cell lines (A498 and ACHN) with IC 50 11.4, 18.7, and 24.4 µM, respectively [ 128 ]. Of the two nonbrominated phorbaketals (L and M) also isolated from this sponge, only phorbaketal L shows cytotoxicity (A498, 17.3 µM).…”

Section: Antitumor Compoundsmentioning

confidence: 99%

Biological Activity of Recently Discovered Halogenated Marine Natural Products

2015

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Section: Antitumor Compoundsmentioning

confidence: 99%

Biological Activity of Recently Discovered Halogenated Marine Natural Products

2015

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“…from Gageo Island, Korea, and phorbaketal N (Scheme 9, 34) contains bromine. [11] This novel metabolite exhibits potent cytotoxicity against human pancreas cancer cells (Panc-1) and human renal cancer cells (A498 and ACHN), and is more cytotoxic than fluorouracil in these screens.…”

Section: Algaementioning

confidence: 96%

A recent survey of naturally occurring organohalogen compounds

2015

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Environmental context. The general perception that nature does not produce compounds containing halogens -chlorine, bromine, iodine and fluorine -is now known to be erroneous. Modern isolation and identification techniques have led to the discovery of more than 5000 halogen-containing compounds from myriad marine and terrestrial plant and animal sources. Many of these compounds possess extraordinary biological activity, including anticancer, antiviral and antibacterial activity of potential human benefit.Abstract. This short review presents the naturally occurring organohalogen compounds discovered and characterised in 2014. They include compounds from both marine and terrestrial organisms, such as algae, sponges, corals, tunicates, bryozoans, fungi, bacteria, cyanobacteria and plants. Several novel structural types have been characterised. From only ,24 in 1968, naturally occurring organohalogens currently number more than 5000, and they continue to be discovered in all regions of the world. This review presents the 114 discovered organohalogens from natural sources in the year 2014.The enormous upsurge in the total number of natural organohalogens discovered since 1968 arises from several factors: (1) a worldwide revitalisation of natural products research in the search for new medicinal compounds from all aspects of our environment, (2) improved isolation, separation and identification techniques, (3) selective bioassays to identify biologically active extracts, (4) an awareness of folk medicine and ethnobotany for guidance to potentially important organisms.

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“…8 ). 27 Phorbaketals showed various cytotoxic potential against different cell lines as colorectal carcinoma (HT-29), hepatocellular carcinoma (HepG2), lung cancer (A549), pancreatic cancer (panc-1) and renal cancer (A498 and ACHN) with IC 50 values of 11.4–50 μM. 25 Phorbaketal N revealed higher cytotoxic activity against pancreatic cancer cell line with IC 50 value of 11.…”

Section: Isolated Bioactive Compounds From Family Hymedesmiidaementioning

confidence: 99%

“…4 μM compared to fluorouracil, the positive control. 27 Moreover, phorbaketal A revealed potent anti-inflammatory activity via inhibition the release of nitric oxide (NO). 28 Besides, anti-HIV sesterterpenoids were isolated from phorbas sp., namely alotaketals C (48) and D (49), ansellone A (50), and anvilone A (51) ( Fig.…”

Section: Isolated Bioactive Compounds From Family Hymedesmiidaementioning

confidence: 99%