Photobiology of Melanins

Young, Antony R.

doi:10.1002/9780470987100.ch17

Cited by 4 publications

(3 citation statements)

References 97 publications

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“…The fair‐skinned participants were therefore treated with lower doses of UV‐B than were the dark‐skinned participants. Consequently, it is difficult to interpret the results as it is debated whether skin pigmentation reduces vitamin D production (18,37,38). Further, recent studies have shown that baseline 25(OH)D influences the production of 25(OH)D after UV‐B exposure (18,20–22,39).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D production depends on ultraviolet-B dose but not on dose rate: A randomized controlled trial

Bogh

Schmedes

Philipsen

et al. 2010

Experimental Dermatology

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Section: Discussionmentioning

confidence: 99%

Vitamin D production depends on ultraviolet-B dose but not on dose rate: A randomized controlled trial

Bogh

Schmedes

Philipsen

et al. 2010

Experimental Dermatology

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“…Skin pigmentation is partially determined by a constitutive content and type of melanin [17]. Fair-skinned and black-skinned individuals have similar numbers of melanocytes in the basal cell layer of the skin (12.2-12.8 melanocytes/mm) [18].…”

Section: Discussionmentioning

confidence: 99%

Skin Color Is Relevant to Vitamin D Synthesis

Libon¹,

Cavalier²,

Nikkels³

2013

Dermatology

115

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Background: Whether dark skin produces less vitamin D after UVB radiation than fair skin remains controversial. Objective: To compare 25-hydroxyvitamin D [25-(OH)-D] levels after a single UVB exposure in fair (phototype II-III) and black-skinned (phototype VI) volunteers. Methods: Fair-skinned volunteers (n = 20, 4 males/16 females, mean age: 23.2 years) and black-skinned (n = 11, 6 males/5 females, mean age: 23.8 years) received a single total body UVB exposure (0.022 J/cm²). The 25-(OH)-D levels were measured on days 0, 2 and 6. Results: On day 0, all volunteers were severely vitamin D deficient. On day 2, 25-(OH)-D levels of fair-skinned volunteers increased significantly (median: 11.9-13.3 ng/ml, p < 0.0001), but not in black-skinned people (median: 8.60-8.55 ng/ml, p = 0.843). Again, on day 6, 25-(OH)-D levels of fair-skinned volunteers increased significantly (median: 11.9-14.3 ng/ml, p < 0.0001), but not in black-skinned people (median: 8.60-9.57 ng/ml, p = 0.375). Conclusion: This study suggests that skin pigmentation negatively influences vitamin D synthesis.

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“…Acute effects include DNA and oxidative damage, mutation, immunosuppression, erythema (sunburn) and tanning. The chronic effects include skin cancers, which are thought to be a consequence of mutation, immunosuppression and photoaging, which is thought to be a consequence of the induction of matrix metalloproteinases (MMPs) (Young, 2006). The emission spectrum of the sun is rich in UVA radiation with UVB radiation accounting for less than 5% of total UVR content.…”

Section: Biologic Roles Of Ultraviolet Light In Melanocytesmentioning

confidence: 99%

Melanocyte Pygmentation – Friend or Foe on the Route to Melanoma

Bâldea¹

2011

Breakthroughs in Melanoma Research

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Photobiology of Melanins

Cited by 4 publications

References 97 publications

Vitamin D production depends on ultraviolet-B dose but not on dose rate: A randomized controlled trial

Vitamin D production depends on ultraviolet-B dose but not on dose rate: A randomized controlled trial

Skin Color Is Relevant to Vitamin D Synthesis

Melanocyte Pygmentation – Friend or Foe on the Route to Melanoma

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