Photobiomodulation in Light of Our Biological Clock's Inner Workings

Santana-Blank, Luis; Rodríguez–Santana, Elizabeth

doi:10.1089/pho.2018.4445

Cited by 7 publications

(6 citation statements)

References 23 publications

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“…External optical signals captured by optical photoreceptors are processed and activate the expression of circadian genes in the central nervous system, influencing molecular clocks and having major implications for some diseases [ 247 ].…”

Section: Photobiomodulation Applied On the Gut–lung–brain Axismentioning

confidence: 99%

“…Light could be an allosteric controller for all life-forms, because as Hamblin et al concluded in a recent review “all life-forms respond to light” [ 250 ]; so, light could be able to establish oscillating patterns in our proteins and our organs and could have an impact on our daily rhythms, considering “the seemingly simple, but powerful, idea that repetitive low-energy forces of certain parameters can profoundly affect human physiology” [ 247 ].…”

Section: Photobiomodulation Applied On the Gut–lung–brain Axismentioning

confidence: 99%

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Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges

Ailioaie

Litscher

2021

IJMS

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In recent decades, researchers around the world have been studying intensively how micro-organisms that are present inside living organisms could affect the main processes of life, namely health and pathological conditions of mind or body. They discovered a relationship between the whole microbial colonization and the initiation and development of different medical disorders. Besides already known probiotics, novel products such as postbiotics and paraprobiotics have been developed in recent years to create new non-viable micro-organisms or bacterial-free extracts, which can provide benefits to the host with additional bioactivity to probiotics, but without the risk of side effects. The best alternatives in the use of probiotics and postbiotics to maintain the health of the intestinal microbiota and to prevent the attachment of pathogens to children and adults are highlighted and discussed as controversies and challenges. Updated knowledge of the molecular and cellular mechanisms involved in the balance between microbiota and immune system for the introspection on the gut–lung–brain axis could reveal the latest benefits and perspectives of applied photobiomics for health. Multiple interconditioning between photobiomodulation (PBM), probiotics, and the human microbiota, their effects on the human body, and their implications for the management of viral infectious diseases is essential. Coupled complex PBM and probiotic interventions can control the microbiome, improve the activity of the immune system, and save the lives of people with immune imbalances. There is an urgent need to seek and develop innovative treatments to successfully interact with the microbiota and the human immune system in the coronavirus crisis. In the near future, photobiomics and metabolomics should be applied innovatively in the SARS-CoV-2 crisis (to study and design new therapies for COVID-19 immediately), to discover how bacteria can help us through adequate energy biostimulation to combat this pandemic, so that we can find the key to the hidden code of communication between RNA viruses, bacteria, and our body.

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Section: Photobiomodulation Applied On the Gut–lung–brain Axismentioning

confidence: 99%

Section: Photobiomodulation Applied On the Gut–lung–brain Axismentioning

confidence: 99%

Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges

Ailioaie

Litscher

2021

IJMS

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“…Regarding surgery, even if the traditional trabeculectomy technique remains the gold standard of treatment, the latest research has been focused on improving its risk/benefit ratio for minimally invasive glaucoma surgery (MIGS) [60]. This method could be used in eyes with mild or medium-mild grade glaucoma, or in patients who do not tolerate drops or do not respond to laser treatment, as it is a safe and efficient technique to lower IOP compared to standard surgery; however, its costs are elevated.…”

Section: Current and New Approaches In Glaucoma Treatment Modalitiesmentioning

confidence: 99%

“…Currently, it is well known that, in vivo, LLLT leads to a significant improvement in visual acuity in adolescent and adult patients with amblyopia caused by ametropia or strabismus. This procedure is most effective when an area of the macula is irradiated through the conjunctiva from 1 cm distance for 30 s with a laser light (780 nm, 292 Hz, 1:1 duty cycle; 7.5 mW; spot area 3 mm, repeated on average 3.5 times) [60]. Moreover, two patents were filed concerning LLLT.…”

Section: Existing Patents For Ocular Treatments Using Laser Red Lightmentioning

confidence: 99%

The Potential of Visible and Far-Red to Near-Infrared Light in Glaucoma Neuroprotection

et al. 2021

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Alternative treatment strategies are necessary to reduce the severity of glaucoma, a group of eye conditions that progressively damage the optic nerve and impair vision. The aim of this review is to gain insight into potentially exploitable molecular mechanisms to slow down the death of retinal ganglion cells (RGCs), a fundamental element in the pathophysiology of all forms of glaucoma, and to stimulate adult optic nerve repair. For this purpose, we focus our analysis on both visible and far-red to near-infrared light photobiomodulation (PBM) as phototherapeutic agents, which were recently proposed in RGCs, and on the nerve lamina region neural progenitor cell (ONLR-NPC) niche. Both are suggested as potential strategies in glaucoma neuroprotection. We discuss the impact of beneficial molecular effects of PBM on both mitochondrial derangement and the alteration of ion fluxes that are considered important causes of RGC damage, as well as on the stimulation of progenitor cells. We suggest these are the most promising approaches to prevent excessive neuronal cell loss. We describe the experimental evidence supporting the validity of PBM therapy which, despite being a safe, non-invasive, inexpensive, and easy to administer procedure, has not yet been fully explored in the clinical practice of glaucoma treatment.

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“…This knowledge is particularly important considering that the biphasic nature of PBM reduces efficacy to a narrow window of light doses. 3 The literature points to additional hypotheses that involve changes in the properties of water [22][23][24][25][26] rather than an electronic excitation of a traditional chromophore. The overarching concept is that red-NIR light, with photons too low in energy to generate electronic transitions in water, is absorbed by water molecules near hydrophilic surfaces (exclusion zone [EZ] water 22,27 ) or at the surface of proteins (nanoscopic interfacial water 24 ) due to weak absorption by water molecules.…”

Section: Introductionmentioning

confidence: 99%

Assessment of NIR and THz photostimulation at the cellular and subcellular levels

Denton

Noojin

Pope

2023

Mechanisms of Photobiomodulation Therapy XVII

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The term photobiomodulation (PBM), where modulation usually implies a positive or negative response, has been used to describe a photostimulation effect on cells and tissues that leads to beneficial physiological outcomes, such as increased cellular energetics (ATP) and faster healing. Literature points to multiple hypotheses for the mechanism of PBM therapy when using light in the wavelength range of red to near infrared (NIR). We have used a variety of methods and experimental systems to measure light-dependent biological effects in response to laser parameters that would be expected to produce the physiological effects associated with PBM. Here, we highlight two in vitro experiments addressing two different hypotheses for the mechanism of PBM initiation. First, based on wavelength-dependent efficiencies for nitric oxide (NO) release in hTERT-RPE1 cells, we have used these dependences to determine if optimal NO release correlates to increased activity of complex C-IV in the electron transport chain (ETC). Second, to find any indication that water vibration can lead to stimulation of C-IV activity, we exposed isolated mitochondria with laser light at a frequency of 2.52 terahertz (THz) and compared the results with photostimulation of C-IV activity at 808 nm.

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Photobiomodulation in Light of Our Biological Clock's Inner Workings

Cited by 7 publications

References 23 publications

Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges

Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges

The Potential of Visible and Far-Red to Near-Infrared Light in Glaucoma Neuroprotection

Assessment of NIR and THz photostimulation at the cellular and subcellular levels

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