Photobiomodulation of the dorsal root ganglion for the treatment of low back pain: A pilot study

Holanda, Vanessa M.; Chavantes, Maria Cristina; Silva, Daniela de Fátima Teixeira da; Holanda, Carlos Vanderlei M. de; Oliveira, José Oswaldo de; Wu, Xingjia; Anders, Juanita J.

doi:10.1002/lsm.22522

Cited by 29 publications

(42 citation statements)

References 38 publications

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“…PBM, delivered as low-level laser, has been shown to have a dramatic effect on the cytoskeleton structure of nerve cells, with the rapid formation of transient varicosities, and consequent nerve blockade for pain relief. [45][46][47][48][49] PBM also affects the cytoskeleton of other cells besides neurons, such as epithelial cells, 50 keratinocytes, 51 and fibroblasts, 52 and has been shown to have effects on protein conformation, including calcium ion channels. [53][54][55] PBM also has an effect on brain oscillation patterns, with changes to alpha, beta, gamma, delta, and theta waves in both mice 56 and humans 57 (El Khoury, et al, unpublished observations) and effects on the default mode network.…”

Section: Photobiomodulationmentioning

confidence: 99%

“Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?

Liebert

Bicknell

Johnstone

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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Section: Photobiomodulationmentioning

confidence: 99%

“Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?

Liebert

Bicknell

Johnstone

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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“…Among 17 included studies there were two randomized controlled trials [14,15] and 15 non-randomized studies ( Table 1). The total number of participants in these studies was 599; the median number of participants was 28 (range: 1 to 127) ( Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…The total number of participants in these studies was 599; the median number of participants was 28 (range: 1 to 127) ( Table 1). Both RCTs included participants with low back pain (LBP) [14,15]. Non-randomized studies included patients with the following indications: LBP [16][17][18], postsurgical pain [19][20][21], pain associated with herpes zoster [6], cervicogenic headache [22,23], complex regional pain syndrome type 1 [24,25], intractable vertebral metastatic pain [26], chronic scrotal and inguinal pain [27], occipital radiating pain in rheumatoid arthritis [28] and chronic migraine [29] (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of pulsed radiofrequency as a method of dorsal root ganglia stimulation for treatment of non-neuropathic pain: a systematic review

et al. 2020

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Background: We systematically reviewed the evidence on the efficacy and safety of dorsal root ganglion (DRG) targeted pulsed radiofrequency (PRF) versus any comparator for treatment of non-neuropathic pain. Methods: We searched MEDLINE, CINAHL, Embase, PsycINFO, clinicaltrials.gov and WHO clinical trial register until January 8, 2019. All study designs were eligible. Two authors independently conducted literature screening. Primary outcomes were pain intensity and serious adverse events (SAEs). Secondary outcomes were any other pain-related outcome and any other safety outcome that was reported. We assessed the risk of bias using the Cochrane tool and Risk of Bias In Non-randomized Studies of Interventions (ROBINS-I). We conducted narrative evidence synthesis and assessed the conclusiveness of included studies regarding efficacy and safety. Results: We included 17 studies with 599 participants, which analyzed various pain syndromes. Two studies were randomized controlled trials; both included participants with low back pain (LBP). Non-randomized studies included patients with the following indications: LBP, postsurgical pain, pain associated with herpes zoster, cervicogenic headache, complex regional pain syndrome type 1, intractable vertebral metastatic pain, chronic scrotal and inguinal pain, occipital radiating pain in rheumatoid arthritis and chronic migraine. In these studies, the PRF was usually initiated after other treatments have failed. Eleven studies had positive conclusive statements (11/17) about efficacy; the remaining had positive inconclusive statements. Only three studies provided conclusiveness of evidence statements regarding safetytwo indicated that the evidence was positive conclusive, and one positive inconclusive. The risk of bias was predominantly unclear in randomized and serious in non-randomized studies.

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“…Pain is costly to the nation as it requires medical treatment, complicates medical treatment for other conditions, and hinders people's ability to work and function in the society (41). Low back pain is one of the biggest subset of chronic pain in terms of economic burdens (42-45) and neuromodulation procedures have been targeting these pathways to provide a clinically meaningful and cost effective response (46)(47)(48)(49)(50)(51)(52)(53)(54)(55).…”

Section: Discussionmentioning

confidence: 99%