Photobiomodulation therapy was more effective than photobiomodulation plus arginine on accelerating wound healing in an animal model of delayed healing wound

Mostafavinia, Atarodsadat; Amini, Abdollah; Sajadi, Ensieh; Ahmadi, Houssein; Rezaei, Fatemehalsadat; Ghoreishi, Seyed Kamran; Chien, Sufan; Bayat, Mohammad

doi:10.1007/s10103-021-03271-8

Cited by 6 publications

(14 citation statements)

References 32 publications

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“…75,76 Increases of VEGFA gene expression by photobiomodulation therapy have been associated with acceleration of wound healing in a mouse model. 47 The decreased TGFB1, PDGFC and VEGFA levels observed under TH2 conditions in keratinocytes and fibroblasts, probably accounting for the reduced scratch healing found here, could not be restored by WTD treatment. Therefore, the mechanism by which WTD optimizes wound healing in a TH2-dominant milieu differs from wIRA radiation, for which a significant increase in TGFB1 and PDGFC transcript levels of keratinocytes and fibroblasts was found after treatment.…”

Section: F I G U R Ementioning

confidence: 56%

“…Positive effects of photobiomodulation on wound healing have been described, 47–49 which most likely can be explained by enhanced fibroblast migration and proliferation as well as augmented collagen synthesis 50,51 . and accelerated tissue perfusion 52 by increased angiogenesis 47,53–55 . Distinct effects on timing and release of growth factors and cytokines for example by LLLT have been noted 56 .…”

Section: Discussionmentioning

confidence: 99%

“…9,45 Furthermore, impaired wound healing in keratinocytes treated with IL-4 10 or keratinocytes and fibroblasts stimulated with IL-4 and IL-13 25 has been demonstrated, which is consistent with lower wound healing rates found in atopic children. 46 Positive effects of photobiomodulation on wound healing have been described, [47][48][49] which most likely can be explained by enhanced fibroblast migration and proliferation as well as augmented collagen synthesis. 50,51 and accelerated tissue perfusion 52 by increased angiogenesis.…”

Section: F I G U R Ementioning

confidence: 99%

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Treatment with a red‐laser‐based wound therapy device exerts positive effects in models of delayed keratinocyte and fibroblast wound healing

Wiegand,

Dirksen,

Tittelbach

2023

Photoderm Photoimm Photomed

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BackgroundLight therapy is widely used in medicine. Specifically, photobiomodulation has been shown to exert beneficial effects in wound healing disorders, which present a major challenge in health care. The study's aim was providing information on the effect of a novel, red‐laser‐based wound therapy device (WTD) on keratinocytes and fibroblasts during wound healing under optimal and non‐optimal conditions.MethodsThe scratch wound assay was employed as a wound healing model for mechanical damage with readjustment of specific cell milieus, explicitly chronic TH1 inflammation and TH2‐dominant conditions. Furthermore, gene expression analysis of pro‐inflammatory cytokines (IL1A, IL6, CXCL8), growth factors (TGFB1, PDGFC), transcription factors (NFKB1, TP53) and heat shock proteins (HSP90AA1, HSPA1A, HSPD1) as well as desmogleins (DSG1, DSG3) in keratinocytes and collagen (COL1A1, COL3A1) in fibroblasts was performed after WTD treatment.ResultsIt was shown that WTD treatment is biocompatible and supports scratch wound closure under non‐optimal conditions. A distinct enhancement of desmoglein and collagen gene expression as well as induction of early growth factor gene expression was observed under chronic inflammatory conditions. Moreover, WTD increased HSPD1 transcript levels in keratinocytes and augmented collagen expression in fibroblasts during wound healing under TH2 conditions. WTD treatment also alleviated the inflammatory response in keratinocytes and induced early growth factor gene expression in fibroblasts under physiological conditions.ConclusionPositive effects described for wound treatment with WTD could be replicated in vitro and seem to be to be conferred by a direct influence on cellular processes taking place in keratinocytes and fibroblasts during wound healing.

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Section: F I G U R Ementioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

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Treatment with a red‐laser‐based wound therapy device exerts positive effects in models of delayed keratinocyte and fibroblast wound healing

Wiegand,

Dirksen,

Tittelbach

2023

Photoderm Photoimm Photomed

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“…There are low-intensity laser-sensitive photoreceptors in the mitochondria membranes. 35,36 Photon absorption by the photoreceptors activates molecular signals in these receptors and alters the molecular configuration of the cells. 12,37 The signal between the nucleus and mitochondria affects many cellular activities in both pathological and normal conditions, 35,38 although the optimal result of PBM is seen in stressed cells more than it is seen in healthy cells.…”

Section: Mechanism Of Photobiomodulation On Atp Ca and Rosmentioning

confidence: 99%

Preclinical and Clinical Applications of Photobiomodulation Therapy in Sperm Motility: A Narrative Review

et al. 2022

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About 50% of infertility problems are related to male factors and reduced sperm motility. The important factor that affects the structure and function of sperm is reactive oxygen species (ROS), and over-concentration of ROS reduces the quality and motility of sperm. Photobiomodulation therapy (PBMT) using red to near-infrared (NIR) light is useful in oxidative stress restoration. It plays a therapeutic role in disorders such as asthenospermia, oligospermia cases, and cryopreserved sperm. It also enhances the metabolic capacity of sperm and increases the low-level and non-harmful intracellular content of Ca2+, nitric oxide (NO), and ROS in the stressed cells. Likewise, it modulates survival intracellular pathways and maintains the motility, viability, DNA, and acrosome integrity of sperm. This article reviews the state-of-the-art preclinical and clinical evidence regarding the efficacy of semen PBMT.

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“…10 In diabetic wound healing, photobiomodulation therapy (PBMT) decreases inflammation, stimulates healing, and relieves pain, through the modification of cellular and molecular pathways. 11 Ischemic tissues treated with PBMT show an improvement in angiogenesis and nitric oxide release along with increasing the cells expressing vascular endothelial growth factor (VEGF) and hypoxiainducible factor alpha (HIF-1). [12][13][14] Furthermore, PBMT may improve the survival rate of skin flaps via increasing the number of new vascular developments in the tissue, modifying VEGF discharge, matrix metalloproteinase-2 (MMP-2) stimulation, and HIF-1 expression.…”

Section: Introductionmentioning

confidence: 99%

The Combined Effects of a Methacrylate Powder Dressing (Altrazeal Powder) and Photobiomodulation Therapy on the Healing of a Severe Diabetic Foot Ulcer in a Diabetic Patient: A Case Report

et al. 2022

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Weakened wound healing is a popular, severe complication of patients with diabetes which poses a risk for foot infection and amputation. Researchers have searched for new treatments for treating diabetic foot ulcers (DFUs) in recent years. In this case report, for the first time, we applied photobiomodulation therapy (PBMT) and Altrazeal powder together to treat a severe case of DFU in a 47-year-old woman who was suffering from type 1 diabetes. Along with the progress of combination therapy, we observed that the ulcer area was significantly reduced, and the wound healed within 16 weeks. Furthermore, dermatitis and purulent secretion were treated, and the pain was reduced. This reported case study indicated the beneficial effect of the combination of PBMT and Altrazeal powder for the healing of a severe DFU in a patient with type one diabetes. The combined application of PBMT plus Altrazeal powder demonstrated an additive effect. Further clinical trials in the clinical setting are suggested to validate the results further. Besides, more studies in preclinical models are suggested to find the mechanism of the action of combination therapy.

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Photobiomodulation therapy was more effective than photobiomodulation plus arginine on accelerating wound healing in an animal model of delayed healing wound

Cited by 6 publications

References 32 publications

Treatment with a red‐laser‐based wound therapy device exerts positive effects in models of delayed keratinocyte and fibroblast wound healing

Treatment with a red‐laser‐based wound therapy device exerts positive effects in models of delayed keratinocyte and fibroblast wound healing

Preclinical and Clinical Applications of Photobiomodulation Therapy in Sperm Motility: A Narrative Review

The Combined Effects of a Methacrylate Powder Dressing (Altrazeal Powder) and Photobiomodulation Therapy on the Healing of a Severe Diabetic Foot Ulcer in a Diabetic Patient: A Case Report

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