Photocatalytic probing of DNA sequence by using TiO2/dopamine-DNA triads

Liu, Jian‐Qin; Garza, Linda de la; Zhang, Ligang; Dimitrijević, Nada M.; Zuo, Xiaobing; Tiede, David M.; Rajh, Tijana

doi:10.1016/j.chemphys.2007.07.040

Cited by 41 publications

(60 citation statements)

References 66 publications

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“…57 The extent of photoreduction of the adsorbed Ag + cations (serving as a measure of negative charge stored on the nanoparticle) exponentially decreased with the overall length of the GG-terminated duplex, suggesting that the yield of the oxidation was determined by the efficiency of the forward electron transfer: the further was the locus of the electron donating GG site, the lower was the probability of electron transfer to this site. 58 For example, for the GG sites located 7 nm from the surface the reduction of Ag + was only ~ 1/3 of that at 1 nm (in the GG-interspersed (TA) n duplexes of the same overall length). Including single-G hopping sites into the GG-terminate duplexes increased the efficiency of charge separation, providing “stepping stones” for the charge transfer.…”

Section: Discussionmentioning

confidence: 99%

Photooxidation of Nucleic Acids on Metal Oxides: Physicochemical and Astrobiological Perspectives

et al. 2011

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Photocatalytic oxidation of nucleic acid components on aqueous metal oxides (TiO2, α-FeOOH, and α-Fe2O3) has been studied. The oxidation of purine nucleotides results in the formation of the purine radical cations and sugar-phosphate radicals, whereas the oxidation of pyrimidine nucleotides other than thymine results in the oxidation of only the sugar-phosphate. The oxidation of the thymine (and to a far less extent for the 5-methylcytosine) derivatives results in deprotonation from the methyl group of the base. Some single stranded (ss) oligoribonucleotides and wild-type ss RNA were oxidized at purine sites. In contrast, double stranded (ds) oligoribonucleotides and DNA were not oxidized. These results account for observations suggesting that cellular ds DNA is not damaged by exposure to photoirradiated TiO2 nanoparticles inserted into the cell, whereas ss RNA is extensively damaged. The astrobiological import of our observations is that the rapid degradation of monomer nucleotides make them poor targets as biosignatures, whereas duplex DNA is a better target as it is resilient to oxidative diagenesis. Another import of our studies is that ds DNA (as opposed to ss RNA) appears to be optimized to withstand oxidative stress both due to the advantageous polymer morphology and the subtle details of its radical chemistry. This peculiarity may account for the preference for DNA over RNA as a “molecule of life” provided that metal oxides served as the template for synthesis of polynucleotides, as suggested by Orgel and others.

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Section: Discussionmentioning

confidence: 99%

Photooxidation of Nucleic Acids on Metal Oxides: Physicochemical and Astrobiological Perspectives

et al. 2011

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“…Moreover, stability of the bonding between the specific functional molecules and nanoparticles is crucial for most medical applications because the particle is the key to tracking or targeting treatments that the functional molecule is to perform. Previous spectroscopic studies suggested that bidentate enediols could tightly bind to iron oxide materials, leading to a stable chelate [18,[21][22][23][24][25]. We choose dopamine and catechaldehyde as the catechol derivative anchors since they bear reactive chemical group such as amino and formyl group, respectively, which will act as coupling link for further conjugation with cell targeting agents.…”

Section: Introductionmentioning

confidence: 99%

Catechol derivatives-coated Fe3O4 and γ-Fe2O3 nanoparticles as potential MRI contrast agents

Basti

Tahar

Smiri

et al. 2010

Journal of Colloid and Interface Science

161

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“…1,2,4,6,7,9,10 When these experiments are carried out, the same type of spectroscopic red-shift is seen for these particles as for those functionalized with dopamine alone. 2 In order for these bioconjugated particle materials to be used as probes in Raman-based biodetection/imaging strategies, it also is necessary that these colloids exhibit a distinct Raman signature.…”

Section: Biological Relevancementioning

confidence: 63%

“…2 The unique combination of the electronic properties of the nanoparticle and the chemical and biological recognition properties of the biomolecule have allowed these conjugates to be utilized in certain biodiagnostic and nanotherapeutic applications. 1,2,4,[6][7][8][9][10] So far, the majority of surface-enhanced Raman spectroscopy (SERS) experiments were restricted to the use of metallic, in particular silver and gold nanocrystalline aggregates. There are few reports of semiconductor supported SERS.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic studies into the Raman enhancement of enediol-semiconducting nanoparticle conjugates and their use in biological applications

et al. 2010

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Raman scattering enhancement was observed in systems where different metal oxide semiconductors (TiO 2 , Fe 2 O 3 , ZrO 2 and CeO 2 ) were modified with enediol ligands. The intensity of Raman scattering was dependent on laser frequency and correlated with the extinction coefficient of the charge-transfer complex of the enediol ligands and nanoparticles. The intensity and frequency of the Raman bands was found to depend on the chemical composition of the enediol ligand and the chemical composition (and crystallinity) of the nanoparticles. The intensity of the Raman signal depends on the number of surface binding sites, electron density of the ligands and their dipole moment. We also found that Raman scattering is observed for the bioconjugated system, where a peptide is linked to the surface of the particle through a catechol linker. These studies are important since these bioconjugates can be used to form the basis of Raman-based, in vitro and importantly in vivo biodetection, cell labeling and imaging, and nanotherapeutic strategies.

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Photocatalytic probing of DNA sequence by using TiO2/dopamine-DNA triads

Cited by 41 publications

References 66 publications

Photooxidation of Nucleic Acids on Metal Oxides: Physicochemical and Astrobiological Perspectives

Photooxidation of Nucleic Acids on Metal Oxides: Physicochemical and Astrobiological Perspectives

Catechol derivatives-coated Fe3O4 and γ-Fe2O3 nanoparticles as potential MRI contrast agents

Mechanistic studies into the Raman enhancement of enediol-semiconducting nanoparticle conjugates and their use in biological applications

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