Photodegradation of Ibuprofen, Cetirizine, and Naproxen by PAN-MWCNT/TiO2–NH2 nanofiber membrane under UV light irradiation

Mohamed, Alaa; Salama, Ahmed; Nasser, Walaa S.; Uheida, Abdusalam

doi:10.1186/s12302-018-0177-6

Cited by 72 publications

(26 citation statements)

References 37 publications

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“…It was indicated that the residual amino acids in test solutions had a contribution on the magnitude of the protective effects for NX photodegradation. Previous studies showed that the photodegradation efficiency of the irradiated compound was dependent on its initial concentration [ 22 ]. In this experiment, it was indicated that amino acids that had protective potencies at a lower concentration might tend to be degradable by photo-irradiation, compared to that at higher concentration.…”

Section: Resultsmentioning

confidence: 99%

Photoprotective Effects of Selected Amino Acids on Naproxen Photodegradation in Aqueous Media

et al. 2020

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It is important to develop a photostabilization strategy to ensure the quality of photosensitive compounds, including pharmaceuticals. This study focused on the protective effects of 20 amino acids on the photodegradation of naproxen (NX), a photosensitive pharmaceutical, to clarify the important nature of a good photostabilizer. Our previous report indicated the photodegradability of NX and the protective effects of some antioxidants on its photodegradation, therefore, this compound was used as a model compound. The degradation of NX in aqueous media during ultraviolet light (UV) irradiation and the protective effects of selected amino acids were monitored through high-performance liquid chromatography (HPLC), equipped with a reverse-phase column. Addition of cysteine, tryptophan, and tyrosine induced the significant suppression of NX photodegradation after UV irradiation for 3 h (residual amount of NX; 15.35%, 6.82%, and 15.64%, respectively). Evaluation of the antioxidative activity and UV absorption spectrum showed that cysteine suppressed NX degradation through its antioxidative ability, while tryptophan and tyrosine suppressed it through their UV filtering ability. Furthermore, three amino acids at higher concentrations (more than 100 µmol/L) showed more protective effects on NX photodegradation. For 10 mmol/L, residual amounts of NX with cysteine, tryptophan, and tyrosine were 58.51%, 69.34%, and 82.40%, respectively. These results showed the importance of both photoprotective potencies (antioxidative potency and UV filtering potency) and stability to UV irradiation for a good photostabilizer of photosensitive pharmaceuticals.

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Section: Resultsmentioning

confidence: 99%

Photoprotective Effects of Selected Amino Acids on Naproxen Photodegradation in Aqueous Media

et al. 2020

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“…In addition, the intermediates and final products that are generated in the wake of these photochemical reactions may also change the pH of the environment. Moreover, the drug may be more stable in its ionized or non-ionized form and may undergo specific acid-base catalysis in aqueous solutions [26,27]. It is well-known that the photodegradation of drugs is significantly affected by the pH of the environment because the changes in pH can promote or inhibit photolysis [26].…”

Section: Percentage Of Degradation Of Eme Epi and Ketmentioning

confidence: 99%

Section: Percentage Of Degradation Of Eme Epi and Ketmentioning

confidence: 99%

Photodegradation of the H1 Antihistaminic Topical Drugs Emedastine, Epinastine, and Ketotifen and ROS Tests for Estimations of Their Potent Phototoxicity

et al. 2020

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In this study, important H1 antihistaminic drugs, i.e., emedastine (EME), epinastine (EPI), and ketotifen (KET), were irradiated with UV/Vis light (300–800 nm) in solutions of different pH values. Next, they were analyzed by new high performance liquid chromatography (HPLC) methods, in order to estimate the percentage of degradation and respective kinetics. Subsequently, ultra-performance liquid chromatography tandem-mass spectrometry (UPLC-MS/MS) was used to identify their photodegradation products and to propose degradation pathways. In addition, the peroxidation of linoleic acid and generation of singlet oxygen (SO) and superoxide anion (SA) were examined, together with the molar extinction coefficient (MEC) evaluation, to estimate their phototoxic risk. The photodegradation of all EME, EPI, and KET followed pseudo first-order kinetics. At pH values of 7.0 and 10.0, EPI was shown to be rather stable. However, its photostability was lower at pH 3.0. EME was shown to be photolabile in the whole range of pH values. In turn, KET was shown to be moderately labile at pH 3.0 and 7.0. However, it degraded completely in the buffer of pH 10.0. As a result, several photodegradation products were separated and identified using the UPLC-MS/MS method. Finally, our ROS assays showed a potent phototoxic risk in the following drug order: EPI < EME < KET. All of these results may be helpful for manufacturing, storing, and applying these substantial drugs, especially in their ocular formulations.

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“…In one bench-scale study it was found that the ibuprofen removal rates ranged between 2 and 80% with varying PAC concentrations in the 1-20-mg/L range (Westerhoff et al, 2005). • Ultraviolet (UV) radiation with an intensity designed to simulate solar irradiation was reported to cause a range of 62-67% ibuprofen photodegradation in various source waters spiked with high contaminant concentrations (10-40 mg/L) (Mohamed et al, 2018).…”

Section: Abatement Techniquesmentioning

confidence: 99%

Applications of Metal Organic Frameworks in Wastewater Treatment: A Review on Adsorption and Photodegradation

et al. 2020

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The growing accumulation of emerging contaminants in the environment can cause direct and indirect water pollution that puts human lives at risk. The fact that these contaminants are not or cannot be eliminated from the municipal water utilities, poses a significant concern. Researchers are currently pulling massive attention to improve existing technologies, develop new strategies, and provide environmentally durable solutions to mitigate water contamination problems. Adsorption and photodegradation are two of the most sustainable technologies that are used in water purification. These technologies have many advantages because of the economic, simple, and easily operated designs needed to treat wastewater. Within these applications, metal organic frameworks (MOFs) are playing a significant role as novel class of porous materials characterized by a crystalline structure. MOFs are considered good candidates to be employed in wastewater treatment technologies because of the tunability of their features. The scope of this review article is to provide a comprehensive description of the recent studies published in the literature about the adsorptive and photocatalytic use of MOFs for the removal of organic emerging contaminants from wastewater. Furthermore, this study briefly highlights the synthesis technologies of MOFs. Finally, future perspective and challenges associated with MOF large-scale production are discussed.

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Photodegradation of Ibuprofen, Cetirizine, and Naproxen by PAN-MWCNT/TiO2–NH2 nanofiber membrane under UV light irradiation

Cited by 72 publications

References 37 publications

Photoprotective Effects of Selected Amino Acids on Naproxen Photodegradation in Aqueous Media

Photoprotective Effects of Selected Amino Acids on Naproxen Photodegradation in Aqueous Media

Photodegradation of the H1 Antihistaminic Topical Drugs Emedastine, Epinastine, and Ketotifen and ROS Tests for Estimations of Their Potent Phototoxicity

Applications of Metal Organic Frameworks in Wastewater Treatment: A Review on Adsorption and Photodegradation

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