Photodynamic effect of radiation with the wavelength 405 nm on the cells of microorganisms sensitised by metalloporphyrin compounds

Metalloporphyrins in Medicine: From History to Recent Trends

“…We make no mistake to say that as the purpose of photodynamic therapy changes, the properties of Ps will also be modified. We are already able to observe current wide porphyrin integration in science and medicine (Figure ): Zn containing MeP are applied mostly in PDT, visualization, and theranostics; ,− ,− ,,,, Mn containing MeP are applied as effective contrast agents, radioprotectors, and components for catalyst therapy; − ,,,,,, Gd and Pt containing MeP are applied are used in PDT, MRI, and theranostics. ,,,,,− MePs have been integrated into various fields of medicine because they play a significant role in living organisms. Over the past few years, MeP development for visualization, protection and wound healing applications have received increased attention.…”

“…The ZnP modified with methoxy group on meso -phenyl groups displayed activity against Candida albicans fungi. Decoration of ZnP with butyl radical in the third and fourth positions of the pyridine ring increased its antimicrobial activity against Gram-negative and Gram-positive bacteria. , Ravikumar and coauthors reported on SnP activity against Bacillus subtilis and Escherichia coli triggered by direct DNA damage via groove binding . S. Moghnie and co-workers have tested the antifungal properties of Zn (II) cationic meso -tetrakis­( N -alkylpyridinium-2-yl)­porphyrin on Saccharomyces cerevisiae and found that MeP modification in four pyridyl nitrogens of meso positions to six-carbon aliphatic chains significantly increased the PS hydrophilicity and its photoactivity compared to commercially available chlorin e6 …”