Photodynamic inactivation of oral paracoccidioidomycosis affecting woman with systemic lupus erythematosus: An unusual case report

Ribeiro, Cínthia Magalhães; Caixeta, Clenivaldo Alves; Carli, Marina Lara de; Sperandio, Felipe Fornias; Magalhães, Evandro Monteiro de Sá; Pereira, Alessandro Antônio Costa; Hanemann, João Adolfo Costa

doi:10.1016/j.pdpdt.2016.12.006

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…Ribeiro et al 45 reported a single case of PDT treatment for an oral lesion caused by Paracoccidioides brasiliensis. Histological and serologic confirmation of paracoccidioidomycosis (PCM) was previously obtained.…”

Section: Resultsmentioning

confidence: 99%

Topical photodynamic therapy in the treatment of benign oral mucosal lesions: A systematic review

Romano

Stasio

Lauritano

et al. 2020

J Oral Pathology Medicine

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Background The introduction of photodynamic therapy (PDT) in various branches of the dental field such as endodontics, implantology, periodontology, and restorative dentistry and oral medicine has become useful in recent decades. This systematic review presents an overview of the literature to evaluate the usefulness of topical PDT for the treatment of benign oral soft tissue lesions and to identify limitations in prior studies to improve PDT applications. Methods We performed a review of the literature using different search engines (PubMed, ISI Web of Science, and the Cochrane Library) employing MeSH terms such as "Photodynamic therapy" and "PDT" in conjunction with other terms. We utilized the Population, Intervention, Comparison, Outcomes, and Study design (PICOS) method to define our study eligibility criteria. Results Initial results were 1513. Finally, there were only 21 studies that met our selection criteria. We divided the 21 selected items into two groups: inflammatory diseases and infective diseases. Conclusions Although topical PDT is an easy to perform and well‐tolerated treatment and appears to be a valid method with promising results in the treatment of benign lesions of the oral cavity's soft tissues, further studies are needed to complete the current knowledge of this technique.

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Section: Resultsmentioning

confidence: 99%

Topical photodynamic therapy in the treatment of benign oral mucosal lesions: A systematic review

Romano

Stasio

Lauritano

et al. 2020

J Oral Pathology Medicine

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“…Em oposição ao tratamento convencional, a PDT não produz resistência do patógeno e ainda pode ser utilizada para microrganismos que já adquiriram resistência medicamentosa [18]. Já existe relato de caso onde a PDT utilizada como coadjuvante na terapia com itraconazol, em lesões orais por P. brasiliensis, foi observado regressão das lesões e ausência de dor em apenas 4 dias após o início do tratamento com PDT [19].…”

Section: Discussionunclassified

Terapia fotodinâmica na artrite experimental induzida por Paracoccidioides brasiliensis

Genske

Loth

Cecatto

et al. 2019

Sci Med

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AIMS: To evaluate the effectiveness of photodynamic therapy with Brilliant Blue G in the treatment of an experimental model of arthritis by Paracoccidioides brasiliensis (P. brasiliensis). METHODS: After the induction of experimental arthritis with isolated from P. brasiliensis of lineage Pb18 in the knees of Wistar rats, the animals were divided into groups and submitted to photodynamic therapy with intra-articular Brilliant Blue G photosensitizer and laser therapy only, without Brilliant Blue G. All groups received their respective treatments from the seventh to the 11th day. For edema analysis, the knee lateral-lateral diameter of each animal was measured daily and after the treatment period the animals were sacrificed for experimental knee dissection and blood collection for analysis by ELISA, in order to quantify levels of anti-P. brasiliensis antibodies. RESULTS: The results showed that the application of photodynamic therapy was able to prevent the formation of edema when compared to the control (p>0.005), as well as the production of anti-Gp-43 antibodies from P. brasiliensis (p=0.001). In the anatomopathological examination it was possible to observe a higher degree of synovitis and a greater presence of granulomas with the fungus inside the group that did not receive treatment when compared to the groups that received the photodynamic therapy. CONCLUSIONS: Photodynamic therapy was effective in attenuating the experimental arthritis induced by P. brasiliensis in the proposed joint model.

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“…In fact, male patients presented negative expression for estrogen receptor‐α (ERα) in PCM oral lesions 13 . Nevertheless, some women have been reported to have oral PCM, 14‐17 which suggests that PCM develops in association with any systemic alteration that results in immunosuppression in females 16 . There is a lack of knowledge about the systemic conditions, epidemiological profile, clinical features of oral lesions and treatment of women affected by PCM, though.…”

Section: Introductionmentioning

confidence: 99%

Oral Paracoccidioidomycosis affecting women: A systematic review

Costa

Carvalho

Sperandio

et al. 2020

Mycoses

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Paracoccidioidomycosis (PCM) is an infection caused by fungi of the genus Paracoccidioides and is marked by a strong predilection for men; nevertheless, some women have had developed PCM and have presented oral involvement by the disease. Objectives: To review all published cases until August 2020 of oral PCM in women, with emphasis on the presence of systemic changes, deleterious habits (tobacco and alcohol) and oral manifestation features through a systematic review. Methods: Observational studies (both prospective and retrospective) and case reports indexed in the Embase, PubMed, Scopus, Web of Science and LIVIVO databases were selected by two reviewers in a two‐phase process following the pre‐established PICOS criteria. Results: Twenty‐five studies met the eligibility criteria and were selected for qualitative synthesis, of which 72 participants were enrolled. Brazilian White women between 40 and 50 years were the most affected and social history revealed them to be housewives or rural workers. Fifteen women (33.3% of the informed cases) presented any systemic change at the time of PCM diagnosis, namely pregnancy, HIV infection and/or depression. Moriform stomatitis was predominant and affected preferentially the gingivae and alveolar processes in the form of a single painful lesion. Most patients were treated with sulfamethoxazole + trimethoprim or itraconazole. Conclusions: Oral PCM in women is rare; some cases showed systemic changes at the time of PCM diagnosis, namely HIV infection, pregnancy and depression. New studies should be conducted to elucidate the influence of systemic alterations on the development of oral PCM in women.

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Photodynamic inactivation of oral paracoccidioidomycosis affecting woman with systemic lupus erythematosus: An unusual case report

Cited by 8 publications

References 16 publications

Topical photodynamic therapy in the treatment of benign oral mucosal lesions: A systematic review

Topical photodynamic therapy in the treatment of benign oral mucosal lesions: A systematic review

Terapia fotodinâmica na artrite experimental induzida por Paracoccidioides brasiliensis

Oral Paracoccidioidomycosis affecting women: A systematic review

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