Photodynamic therapy in superficial bladder cancer: past, present and future

Jichlinski, Patrice; Leisinger, H.-J.

doi:10.1007/s002400100215

Cited by 58 publications

(57 citation statements)

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“…Photosensitizers, oncotropic optical photoreactive chemical compounds and low-output lasers are used for PDT. Recently, similar to urological cancers, good results of PDT have been reported for the intravesical 5-aminolevulinic acid treatment [10] . We examined the efficacy of TiO 2 and LT as photosensitizers in the present study.…”

Section: Discussionmentioning

confidence: 99%

Anti-Tumor Effects of Liposome-Encapsulated Titanium Dioxide in Nude Mice

Chihara¹,

Fujimoto²,

Kondo³

et al. 2007

Pathobiology

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Anatase particles of titanium dioxide (TiO₂) absorb ultraviolet (UV) light which is shorter than 415 nm. Photoexcited TiO₂, a strong oxidizer, is expected to inhibit malignant cell growth. Liposomes accelerate endophagocytosis to the cytoplasm of encapsulated materials. In this study, we examined anti-tumor effects of TiO₂ and liposome-encapsulated TiO₂ (LT) with UVA irradiation by an air pouch cancer model using NBT-II bladder cancer cells, which simulates bladder cancer. Injection of TiO₂ or LT into the air pouch was followed by UVA irradiation via the opened pouch. Tumors of TiO₂ + UVA and LT + UVA groups showed more pronounced necrotic areas, apoptotic indices, nitrotyrosine formation, tumor growth inhibition and increased survival compared with control groups. Especially the LT + UVA group showed more remarkable anti-tumoral effects than the TiO₂ + UVA group, which was associated with higher TiO₂ incorporation. These findings suggest that LT might be more effective than noncoated TiO₂ in the treatment of bladder cancer.

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Section: Discussionmentioning

confidence: 99%

Anti-Tumor Effects of Liposome-Encapsulated Titanium Dioxide in Nude Mice

Chihara¹,

Fujimoto²,

Kondo³

et al. 2007

Pathobiology

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“…PDT has been developed for the treatment of various cancers, e.g. esophagus (Radu et al, 2000), bronchi (Metz & Friedberg 2001, Savary et al, 1997, and bladder (Guillemin et al, 2001, Jichlinski & Leisinger 2001, as well as for other non-oncological applications, such as for the treatment of age-related macular degeneration (AMD) (Brown et al, 2004). Moreover, PDT has also been used as a successful non-invasive therapeutic modality for treating cutaneous neoplasm (Fritsch et al, 1998, Karrer et al, 2001.…”

Section: Targeted Photodynamic Therapymentioning

confidence: 99%

Vascular-Targeted Photodynamic Therapy (VTP)

Kamarulzaman¹,

Benachour²,

Barberi‐Heyob³

et al. 2011

Advances in Cancer Therapy

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“…Solutions of HAL [2 mM] in Tyrode bicarbonate buffer were prepared just prior the use and adjusted to pH 5.3. Rhodamine 101, Na 2 HPO 4 , NaH 2 PO 4 , glutaraldehyde, dimethylsulfoxide, OsO 4 , and ethanol were purchased from Fluka (Buchs, Switzerland) and used without further purification. Sytox green and Dihydro-Rhodamine 123 (DHR123) were obtained from molecular probes (Eugene, OR).…”

Section: Chemicalsmentioning

confidence: 99%

“…In the case of superficial bladder cancer, the lack of selectivity of the first generation photosensitizers (hematoporphyrin derivatives) and some serious adverse effects, including skin photosensitization and loss of bladder capacity, slowed down the initial enthusiasm for this treatment [4]. This was mainly due to the inappropriate localization of the photosensitizing agent in the vessels or in the depth of the bladder wall.…”

Section: Introductionmentioning

confidence: 99%

Hexyl‐aminolevulinate‐mediated photodynamic therapy: How to spare normal urothelium. An in vitro approach

et al. 2006

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Background and Objectives: Photodynamic therapy (PDT) of superficial bladder cancer may cause damages to the normal surrounding bladder wall. Prevention of these is important for bladder healing. We studied the influence of photosensitizer concentration, irradiation parameters, and production of reactive oxygen species (ROS) on the photodynamically induced damage in the porcine urothelium in vitro. The aim was to determine the threshold conditions for the cell survival. Methods: Living porcine bladder mucosae were incubated with solution of hexylester of 5-aminolevulinic acid (HAL). The mucosae were irradiated with increasing doses and cell alterations were evaluated by scanning electron microscopy and by Sytox green fluorescence. The urothelial survival score was correlated with Protoporphyrin IX (PpIX) photobleaching and intracellular fluorescence of Rhodamine 123 reflecting the ROS production. Results: The mortality ratio was dependent on PpIX concentration. After 3 hours of incubation, the threshold radiant exposures for blue light were 0.15 and 0.75 J/cm 2 (irradiance 30 and 75 mW/cm 2 , respectively) and for white light 0.55 J/cm 2 (irradiance 30 mW/cm 2 ). Photobleaching rate increased with decreasing irradiance. Interestingly, the DHR123/R123 reporter system correlated well with the threshold exposures under all conditions used. Conclusions: We have determined radiant exposures sparing half of normal urothelial cells. We propose that the use of low irradiance combined with systems reporting the ROS production in the irradiated tissue could improve the in vivo dosimetry and optimize the PDT. Lasers Surg.

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Photodynamic therapy in superficial bladder cancer: past, present and future

Cited by 58 publications

References 0 publications

Anti-Tumor Effects of Liposome-Encapsulated Titanium Dioxide in Nude Mice

Anti-Tumor Effects of Liposome-Encapsulated Titanium Dioxide in Nude Mice

Vascular-Targeted Photodynamic Therapy (VTP)

Hexyl‐aminolevulinate‐mediated photodynamic therapy: How to spare normal urothelium. An in vitro approach

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