Photodynamic therapy of oral Candida infection in a mouse model

Freire, Fernanda; Ferraresi, Cleber; Jorge, Antônio Olavo Cardoso; Hamblin, Michael R.

doi:10.1016/j.jphotobiol.2016.03.049

Cited by 84 publications

(64 citation statements)

References 36 publications

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“…74 Recently, Hamblin’s research group reported that PDT could effectively be used to treat oral candidiasis in a mouse model. 230 UVA-excited TiO 2 NPs have been used to kill Gram-positive/negative bacteria and fungi, 231 and fullerene-based PDT has been used for both antimicrobial and anticancer therapies, 232 blue-light inactivation of Gram-negative pathogens in bio-films, 233 and even for activation of cell proliferation in skin. 234 A PDT approach has also been reported for treatment of rheumatoid arthritis.…”

Section: Other Applications Of Light In Ddssmentioning

confidence: 99%

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

et al. 2017

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Nanotechnology has begun to play a remarkable role in various fields of science and technology. In biomedical applications, nanoparticles have opened new horizons, especially for biosensing, targeted delivery of therapeutics, and so forth. Among drug delivery systems (DDSs), smart nanocarriers that respond to specific stimuli in their environment represent a growing field. Nanoplatforms that can be activated by an external application of light can be used for a wide variety of photoactivated therapies, especially light-triggered DDSs, relying on photoisomerization, photo-cross-linking/un-cross-linking, photoreduction, and so forth. In addition, light activation has potential in photodynamic therapy, photothermal therapy, radiotherapy, protected delivery of bioactive moieties, anticancer drug delivery systems, and theranostics (i.e., real-time monitoring and tracking combined with a therapeutic action to different diseases sites and organs). Combinations of these approaches can lead to enhanced and synergistic therapies, employing light as a trigger or for activation. Nonlinear light absorption mechanisms such as two-photon absorption and photon upconversion have been employed in the design of light-responsive DDSs. The integration of a light stimulus into dual/multiresponsive nanocarriers can provide spatiotemporal controlled delivery and release of therapeutic agents, targeted and controlled nanosystems, combined delivery of two or more agents, their on-demand release under specific conditions, and so forth. Overall, light-activated nanomedicines and DDSs are expected to provide more effective therapies against serious diseases such as cancers, inflammation, infections, and cardiovascular disease with reduced side effects and will open new doors toward the treatment of patients worldwide.

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Section: Other Applications Of Light In Ddssmentioning

confidence: 99%

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

et al. 2017

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“…A mouse model of a partial thickness skin abrasion infected with bioluminescent A. baumannii gave an increased rate of loss of bioluminescence signal when iodide (10 mM) was combined with LC16 and then illuminated with either UVA or with white light. Finally addition of iodide was tested in a mouse model of oral candidiasis infection mediated by MB and red light [150]. Although we have not yet specifically published a paper looking at the effect of iodide on potentiating APDI destruction of bacterial biofilms, preliminary data have shown that KI makes a surprisingly large difference to the number of logs of killing.…”

Section: Biofilm Resistance To Apdimentioning

confidence: 99%

Can microbial cells develop resistance to oxidative stress in antimicrobial photodynamic inactivation?

Kashef

Hamblin

2017

Drug Resistance Updates

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Infections have been a major cause of disease throughout the history of humans on earth. With the introduction of antibiotics, it was thought that infections had been conquered. However, bacteria have been able to develop resistance to antibiotics at an exponentially increasing rate. The growing threat from multi-drug resistant organisms calls for intensive action to prevent the emergence of totally resistant and untreatable infections. Novel, non-invasive, non-antibiotic strategies are needed that act more efficiently and faster than current antibiotics. One promising alternative is antimicrobial photodynamic inactivation (APDI), an approach that produces reactive oxygen species when dyes and light are combined. So far, it has been questionable if bacteria can develop resistance against APDI. This review paper gives an overview of recent studies concerning the susceptibility of bacteria towards oxidative stress, and suggests possible mechanisms of the development of APDI-resistance that should at least be addressed. Some ways to potentiate APDI and also to overcome future resistance are suggested.

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“…Addition of a simple KI solution to a mixture of microbial cells and many different PS (phenothiazinium dyes [15,16], titanium dioxide photocatalysis [17], and fullerenes [18]) that are subsequently excited by light can give many log units of additional killing (up to 6 logs of extra killing). We recently showed (19) that addition of KI to the traditional anticancer, porphyrin-based PS called Photofrin (PF; porfimer sodium) allowed broad-spectrum aPDI, including the eradication of Gram-negative bacteria that were previously thought to be resistant to PF photodynamic therapy (PDT) (17).…”

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confidence: 99%

Potassium iodide potentiates antimicrobial photodynamic inactivation mediated by Rose Bengal: in vitro and in vivo studies

Wen

Zhang

Szewczyk

et al. 2018

Light-Based Diagnosis and Treatment of Infectious Diseases

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Rose bengal (RB) is a halogenated xanthene dye that has been used to mediate antimicrobial photodynamic inactivation for several years. While RB is highly active against Gram-positive bacteria, it is largely inactive in killing Gram-negative bacteria. We have discovered that addition of the nontoxic salt potassium iodide (100 mM) potentiates green light (540-nm)-mediated killing by up to 6 extra logs with the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, the Gram-positive bacterium methicillin-resistant Staphylococcus aureus, and the fungal yeast Candida albicans. The mechanism is proposed to be singlet oxygen addition to iodide anion to form peroxyiodide, which decomposes into radicals and, finally, forms hydrogen peroxide and molecular iodine. The effects of these different bactericidal species can be teased apart by comparing the levels of killing achieved in three different scenarios: (i) cells, RB, and KI are mixed together and then illuminated with green light; (ii) cells and RB are centrifuged, and then KI is added and the mixture is illuminated with green light; and (iii) RB and KI are illuminated with green light, and then cells are added after illumination with the light. We also showed that KI could potentiate RB photodynamic therapy in a mouse model of skin abrasions infected with bioluminescent P. aeruginosa.

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Photodynamic therapy of oral Candida infection in a mouse model

Cited by 84 publications

References 36 publications

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light

Can microbial cells develop resistance to oxidative stress in antimicrobial photodynamic inactivation?

Potassium iodide potentiates antimicrobial photodynamic inactivation mediated by Rose Bengal: in vitro and in vivo studies

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