Photodynamic Therapy with Methyl 5-Aminolevulinate Acid Might Be Ineffective in Recalcitrant Alopecia Totalis Regardless of Using a Microneedle Roller to Increase Skin Penetration

Yoo, Kwang Ho; Lee, Jin Woong; Li, Kapsok; Kim, Beom Joon; Kim, Myeung Nam

doi:10.1111/j.1524-4725.2010.01515.x

Cited by 28 publications

(34 citation statements)

References 16 publications

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“…However, none of their patients achieved hair regrowth after three sessions. Similar results were obtained later in a study conducted on eight patients with AA totalis, who were treated with three sessions of combined MN and MAL‐PDT . However, based on our study results, combination therapy with ALA‐PDT and MN gave better results in terms of hair regrowth.…”

Section: Reportsupporting

confidence: 90%

Combination of photodynamic therapy with 5‐aminolaevulinic acid and microneedling in the treatment of alopecia areata resistant to conventional therapies: our experience with 41 patients

et al. 2019

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Summary Alopecia areata (AA) is a complex immune‐mediated disorder, which is difficult to treat. The available treatment options seem to have limited benefit, help only some patients and have a high relapse rate. We evaluated a new therapeutic option for moderate to severe AA based on the combination of photodynamic therapy (PDT) with 5‐aminolaevulinic acid (ALA) and microneedling (MN). In total, 14 patients were enrolled, and these were randomly divided into 3 groups: Group A (MN alone; n = 9), Group B (ALA‐PDT alone; n = 15) and Group C (combination of MN and ALA‐PDT; n = 17). All patients were treated once every 3 weeks for a total of six treatments. The best clinical outcome was achieved in Group C, with complete hair regrowth observed in three patients, and an improvement of ≥ 50% and < 50% of the treated areas obtained in seven and six patients, respectively. Our report suggests that combination of ALA‐PDT with MN could be an additional therapeutic option in moderate to severe AA, as MN allows better skin penetration of ALA and subsequent indirect immunosuppression.

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Section: Reportsupporting

confidence: 90%

Combination of photodynamic therapy with 5‐aminolaevulinic acid and microneedling in the treatment of alopecia areata resistant to conventional therapies: our experience with 41 patients

et al. 2019

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“…Patients are treated with PDT with MAL with only half scalp application of microneedling. In both study, as none of the patients showed hair growth, authors concluded that PDT with MAL may not be an effective strategy for AA, regardless of adjunctive microneedling to enhance the drug passage deep into the skin [45,46].…”

Section: Evidence For Efficacymentioning

confidence: 94%

Cosmetic Procedures in the Treatment of Alopecia

Kartal¹,

Altunel²,

Gençler³

2017

Hair and Scalp Disorders

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Alopecia has a significant negative impact on the quality of life. Unfortunately, there is no satisfactory cure for most types of alopecia. Alopecia is divided into cicatricial and noncicatricial types. Androgenetic alopecia, alopecia areata, and telogen effluvium are common forms of noncicatricial alopecias. In order to treat or improve the appearance, various procedures that are being applied for different types of alopecia including mesotherapy, microneedling, platelet-rich plasma, low-level light therapy, and stem-cell therapy with variable outcomes are reviewed in this chapter.

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“…These agents include imiquimod,100,101 topical calcineurin inhibitors,102–106 botulinum toxin type A,107 topical tri-iodothyronine ointment,108 photodynamic therapy,109–111 and topical 5-fluorounacil 112…”

Section: Other Therapiesmentioning

confidence: 99%

Alopecia areata: a new treatment plan

Alsantali

2011

CCID

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Many therapeutic modalities have been used to treat alopecia areata, with variable efficacy and safety profiles. Unfortunately, none of these agents is curative or preventive. Also, many of these therapeutic agents have not been subjected to randomized, controlled trials, and, except for topical immunotherapy, there are few published studies on long-term outcomes. The treatment plan is designed according to the patient’s age and extent of disease. In this paper, the therapeutic agents are organized according to their efficacy and safety profiles into first-line, second-line, and third-line options.

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Photodynamic Therapy with Methyl 5-Aminolevulinate Acid Might Be Ineffective in Recalcitrant Alopecia Totalis Regardless of Using a Microneedle Roller to Increase Skin Penetration

Abstract: PDT with MAL may not be effective for the treatment of alopecia totalis, regardless of the use of a microneedle roller to increase skin penetration.

Cited by 28 publications

References 16 publications

Combination of photodynamic therapy with 5‐aminolaevulinic acid and microneedling in the treatment of alopecia areata resistant to conventional therapies: our experience with 41 patients

Combination of photodynamic therapy with 5‐aminolaevulinic acid and microneedling in the treatment of alopecia areata resistant to conventional therapies: our experience with 41 patients

Cosmetic Procedures in the Treatment of Alopecia

Alopecia areata: a new treatment plan

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