Photoperiod affects hepatic and renal cadmium accumulation, metallothionein induction, and cadmium toxicity in the wild bank vole (Clethrionomys glareolus)

Włostowski, Tadeusz; Bonda, Elżbieta; Krasowska, Alicja

doi:10.1016/s0147-6513(03)00109-x

Cited by 37 publications

(34 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Note an increase in apoptotic cells (arrows) and reduction in seminiferous epithelium in the testes after 4 (b) and 8 (c) weeks. Also, see Table 3 Several studies revealed that seasonal changes in body and organ weights of bank voles and other small mammals remain under control of the photoperiod (Dark et al 1983;Bartness et al 2002;Peacock et al 2004;Włostowski et al 2004;Król et al 2005). It is reasonable to conclude that the effect of photoperiod on myocyte and hepatocyte cell size is also mediated through the short-photoperiod mediator melatonin (Bartness et al 2002;Włostowski et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Apoptosis, proliferation, and cell size in seasonal changes of body and organ weight in male bank voles Myodes glareolus

Bonda-Ostaszewska

Włostowski

2015

Mamm Res

View full text Add to dashboard Cite

Adult male bank voles undergo the body and organ regression before winter, and in early spring, they resume the growth and reproductive processes. The aim of the present study was to determine whether the seasonal changes of body and organ weight in these animals depend on changes in the number of cells or their size. To study an autumnal regression, wild adult males captured in August were exposed to short photoperiod for 0, 4, and 8 weeks, while to study a spring resumption, overwintered males caught in March were exposed to long photoperiod for 0, 1, and 4 weeks. Apoptosis, proliferation, and cell size in the skeletal muscles, liver, and testes were examined. The study revealed that the seasonal changes of testes weight were associated with changes in the number of testicular cells. On the contrary, the changes in size of skeletal myocytes and hepatocytes appeared to be responsible for the seasonal changes of body (muscle) and liver weights in these rodents.

show abstract

Section: Discussionmentioning

confidence: 99%

Apoptosis, proliferation, and cell size in seasonal changes of body and organ weight in male bank voles Myodes glareolus

Bonda-Ostaszewska

Włostowski

2015

Mamm Res

View full text Add to dashboard Cite

show abstract

“…However, compared to acute Cd-induced testicular injury, the pathology of testicular injury following repeated Cd exposure has not been fully investigated. Data from our laboratory indicate that hemorrhagic necrosis is a common characteristic of testicular injury induced by dietary Cd (0.4-1.1 µmol/g) in a small rodent, the bank vole, although the liver and kidneys appear to be resistant to the toxic effects of these doses of Cd (Włostowski et al 2004;unpublished observation); still the mechanism by which dietary Cd produces exclusively testicular injury remains to be elucidated. Therefore, the main purpose of this work was to study histopathological changes and apoptosis in the testes of bank voles exposed subchronically to dietary Cd.…”

Section: Introductionmentioning

confidence: 93%

“…The same analysis showed that the grains contained 1.1-1.4 µmol Fe/g dry wt and 0.3-0.4 µmol Zn/g dry wt (Fe-and Zn-adequate diets) and 4.5-4.8 µmol Fe/g dry wt and 1.7-1.8 µmol Zn/g dry wt (diets supplemented with Fe or Zn in excess of nutritional requirements (Groten et al 1991)). Based on our recent experiments, the selected dose of Cd appeared to be nontoxic to the liver and kidneys but toxic to the testes of bank voles raised under a long photoperiod (Włostowski et al 2004;unpublished observation). The experimental protocols were approved by the local ethical committee for performing an experimental study on laboratory animals (Medical Academy in Białystok).…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Testicular toxicity induced by dietary cadmium is associated with decreased testicular zinc and increased hepatic and renal metallothionein and zinc in the bank vole (Clethrionomys glareolus)

2004

View full text Add to dashboard Cite

Mechanism of testicular toxicity induced by dietary cadmium (Cd) has been less investigated than that following acute Cd injection. In the present study we characterized testicular injury in a small rodent, the bank vole, exposed subchronically to dietary Cd in a quantity of 0.9 micromol/g, and determined the importance of some factors (Cd accumulation, metallothionein (MT), oxidative stress, and zinc (Zn)) in the injury. Dietary Cd induced moderate histopathological changes (hemorrhage in interstitium, necrosis and apoptosis in seminiferous tubule epithelium) in young (1 month old) bank voles fed, for 6 weeks, Fe-adequate (1.1-1.4 micromol/g) and Fe-enriched (4.5-4.8 micromol/g) diets. In contrast, adult (5 months old) bank voles appeared to be resistant to the toxic effects of dietary Cd, despite the fact that testicular Cd contents were higher and MT levels lower than those in the young animals. The Cd-induced histopathological changes and apoptosis were accompanied by increased testicular lipid peroxidation, decreased testicular Zn concentration and elevated levels of hepatic and renal MT and Zn. Supplemental dietary Zn (1.7-1.8 micromol/g) prevented the Cd-induced testicular Zn depletion and injury. The data indicate that dietary Cd produces testicular lesions indirectly, through decreasing testicular Zn, which seems to be due to the sequestration of this element by the Cd-induced hepatic and renal MT.

show abstract

“…The metallothionein (MT) content in the liver was determined by a Cd-heme method (23). Briefly, 0.1 ml of the hepatic homogenate was mixed with 1 ml Tris-HCl buffer (0.03 M, pH 7.8) containing 0.01 mg/liter Cd as CdCl 2 and incubated at room temperature for 5 min to saturate the metal-binding sites of MT.…”

Section: Determination Of Mt In Tissuesmentioning

confidence: 99%

Protective Effects of Lactobacillus plantarum CCFM8610 against Chronic Cadmium Toxicity in Mice Indicate Routes of Protection besides Intestinal Sequestration

Zhai

Wang

Zhao

et al. 2014

Appl Environ Microbiol

116

View full text Add to dashboard Cite

cOur previous study confirmed the ability of Lactobacillus plantarum CCFM8610 to protect against acute cadmium (Cd) toxicity in mice. This study was designed to evaluate the protective effects of CCFM8610 against chronic Cd toxicity in mice and to gain insights into the protection mode of this strain. Experimental mice were divided into two groups and exposed to Cd for 8 weeks via drinking water or intraperitoneal injection. Both groups were further divided into four subgroups, control, Cd only, CCFM8610 only, and Cd plus CCFM8610. Levels of Cd were measured in the feces, liver, and kidneys, and alterations of several biomarkers of Cd toxicity were noted. The results showed that when Cd was introduced orally, cotreatment with Cd and CCFM8610 effectively decreased intestinal Cd absorption, reduced Cd accumulation in tissue, alleviated tissue oxidative stress, reversed hepatic and renal damage, and ameliorated the corresponding histopathological changes. When Cd was introduced intraperitoneally, administration of CCFM8610 did not have an impact on tissue Cd accumulation or reverse the activities of antioxidant enzymes. However, CCFM8610 still offered protection against oxidative stress and reversed the alterations of Cd toxicity biomarkers and tissue histopathology. These results suggest that CCFM8610 is effective against chronic cadmium toxicity in mice. Besides intestinal Cd sequestration, CCFM8610 treatment offers direct protection against Cd-induced oxidative stress. We also provide evidence that the latter is unlikely to be mediated via protection against Cd-induced alteration of antioxidant enzyme activities.

show abstract

Photoperiod affects hepatic and renal cadmium accumulation, metallothionein induction, and cadmium toxicity in the wild bank vole (Clethrionomys glareolus)

Cited by 37 publications

References 43 publications

Apoptosis, proliferation, and cell size in seasonal changes of body and organ weight in male bank voles Myodes glareolus

Apoptosis, proliferation, and cell size in seasonal changes of body and organ weight in male bank voles Myodes glareolus

Testicular toxicity induced by dietary cadmium is associated with decreased testicular zinc and increased hepatic and renal metallothionein and zinc in the bank vole (Clethrionomys glareolus)

Protective Effects of Lactobacillus plantarum CCFM8610 against Chronic Cadmium Toxicity in Mice Indicate Routes of Protection besides Intestinal Sequestration

Contact Info

Product

Resources

About