Phylogenetic relationships, evolution, and genetic diversity of the domestic dog

Vilà, Carles; Maldonado, Jesús E.; Wayne, R. K.

doi:10.1093/jhered/90.1.71

Cited by 181 publications

(114 citation statements)

References 29 publications

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“…These observations suggest that the Shiba may have a closer relation with the Korean wolf than Golden retriever. Although it has been estimated by comparing mitochondrial DNA sequences that wolves represented the ancestors of dogs [20], dog breeds could not be differentiated as a distinct cluster on the phylogenetic tree [18]. Additional samples from wolves are needed to make a precise estimation of the relationships among wolves and dog breeds based on D4DR alleles.…”

Section: Evolutionary Perspective Of the Repetitive Region In The Dogmentioning

confidence: 99%

Allelic Variation of the D4 Dopamine Receptor Polymorphic Region in Two Dog Breeds, Golden Retriever and Shiba.

et al. 1999

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ABSTRACT. The D4 dopamine receptor (D4DR) polymorphic region, which is possibly related to the personality trait known as novelty seeking in humans, was examined in 34 dogs from two breeds (Golden retriever and the Japanese indigenous breed, Shiba) by the polymerase chain reaction (PCR), and the DNA sequences of each allele were determined. The polymorphic region of the dog D4DR gene was composed of 39-and 12-base pair (bp) units, and four alleles (A-D) were identified based on the number and/or order of these units. Intra-and inter-breed allele variations were observed. The frequency of the short A allele was dominant (78.9%) in the Golden retriever, while the long D allele was most common (46.7%) in the Shiba. These findings suggested that the allele frequency varied significantly between different breeds, and that analysis of the polymorphism in D4DR might be of use for understanding the behavioral traits of dogs.-KEY WORDS: breed, canine, D4 dopamine receptor, polymorphism, repetitive sequence.

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Section: Evolutionary Perspective Of the Repetitive Region In The Dogmentioning

confidence: 99%

Allelic Variation of the D4 Dopamine Receptor Polymorphic Region in Two Dog Breeds, Golden Retriever and Shiba.

et al. 1999

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“…They were the first domesticated species, serve as valuable companions and service animals, and have been bred to exhibit more phenotypic diversity than any other mammal (1)(2)(3). Dogs were probably domesticated from Eurasian wolves at least 15,000-40,000 years ago (4-6), although the process by which domestication took place, including the specific selected traits and the manner in which selection was performed, is very poorly understood (7,8).…”

mentioning

confidence: 99%

Complex population structure in African village dogs and its implications for inferring dog domestication history

Boyko

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

149

118

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High genetic diversity of East Asian village dogs has recently been used to argue for an East Asian origin of the domestic dog. However, global village dog genetic diversity and the extent to which semiferal village dogs represent distinct, indigenous populations instead of admixtures of various dog breeds has not been quantified. Understanding these issues is critical to properly reconstructing the timing, number, and locations of dog domestication. To address these questions, we sampled 318 village dogs from 7 regions in Egypt, Uganda, and Namibia, measuring genetic diversity >680 bp of the mitochondrial D-loop, 300 SNPs, and 89 microsatellite markers. We also ana- Canis familiaris ͉ microsatellites ͉ principal component analysis ͉ single nucleotide polymorphisms

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“…The genetic drift and founder effect (in the process of domestication and selection) may account for this phenomenon [15,22,27,30,32,33].…”

Section: Discussionmentioning

confidence: 99%

Sequencing of Canine 5-Hydroxytriptamine Receptor (5-HTR) 1B, 2A, 2C Genes and Identification of Polymorphisms in the 5-HTR1B Gene

Masuda

Hashizume

Ogata

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. Polymorphisms of human genes encoding 5-hydroxytriptamine (serotonin) receptors (5-HTRs) are thought to be associated with psychiatric disorders and behavioral traits. In the present study, we searched for corresponding polymorphisms in the dog and compared allelic frequencies for the canine 5-HTR1B, 5-HTR2A, and 5-HTR2C genes among five canine breeds. The canine genes consisted of the following: 5-HTR1B, 1170 bp; 5-HTR2A, 1413 bp; and 5-HTR2C, 1377 bp. All of these genes were highly homologous with the human genes. We found six single nucleotide polymorphisms (SNPs) in the 5-HTR1B gene (G57A, A157C, G246A, C660G, T955C, and G1146C). Genotyping of the respective SNPs revealed that there were inter-breed variations in the genotypes and allelic fre quencies for four out of the six identified SNPs, suggesting that further analyses of the polymorphisms of the 5-HTR1B gene would be useful in order to gain an understanding of the genetic background underlying the diversified behavioral traits among canine species. KEY WORDS: behavior, breed difference, canine, 5-hydroxytriptamine receptor, polymorphism.J. Vet. Med. Sci. 66(8): 965-972, 2004 A number of studies have been recently conducted, particularly in the field of psychiatry, in the attempt to gain a better understanding of the genetic background of the human temperament [25]. However, as social, cultural, and environmental factors exert such profound effects on the development of human brain functions and on the personality in general, it remains extremely difficult to determine the causal relationships between genes and behavior. Companion animals such as dogs, which have a much simpler social system than human beings, but whose rich individuality can nonetheless be described objectively, have been considered as an advantageous object for this type of research that investigates the genetic components of behavioral traits. We therefore undertook an analysis of the genetic background of the canine temperament in order to create a list of polymorphic regions that might serve as possible candidates for influencing the canine temperament; in this context, we have thus far reported the single nucleotide polymorphisms (SNPs) in the cathechol o-methyltransferase gene [17].Serotonin (5-hydroxytriptamine: 5-HT) is an important monoaminergic neurotransmitter, and it is thought to play a considerable role in psychiatric disorders such as depression, anxiety, and substance abuse; the polymorphisms of certain 5-HT receptor genes are suspected to be involved in these disorders. Among the 5-HT receptors, the 5-HT 1B receptor (5-HTR1B) is assumed to be associated with antisocial alcoholism [14] and antisocial substance dependencies in humans [13]. In rodents, 5-HTR1B knockout mice have been shown to display more reactive and less anxious behaviors than their wild-type counterparts [34], and they have also been shown to exhibit enhanced aggressive behavior [26]. As regards the 5-HT 2A receptor (5-HTR2A), even a silent mutation of T102C has been indicated as exerting ...

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Phylogenetic relationships, evolution, and genetic diversity of the domestic dog

Cited by 181 publications

References 29 publications

Allelic Variation of the D4 Dopamine Receptor Polymorphic Region in Two Dog Breeds, Golden Retriever and Shiba.

Allelic Variation of the D4 Dopamine Receptor Polymorphic Region in Two Dog Breeds, Golden Retriever and Shiba.

Complex population structure in African village dogs and its implications for inferring dog domestication history

Sequencing of Canine 5-Hydroxytriptamine Receptor (5-HTR) 1B, 2A, 2C Genes and Identification of Polymorphisms in the 5-HTR1B Gene

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