Phylogenetic relationships of rodents on the basis of isoenzymes of lactate dehydrogenase

Jacobson, K. Bruce; Murphy, Joe; Dunaway, P.B.

doi:10.1016/0010-406x(69)90553-2

Cited by 16 publications

(1 citation statement)

References 28 publications

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“…LDH5 is the slowest moving-i.e., appears closest to the cathode, and corresponds to the formula M4. However, a sixth isoenzyme of lactic dehydrogenase occurs in the kidney and heart of Mongolian gerbils (617) as well as in human sperm and testicular tissue (410); this indicates that the structure of lactic dehydrogenase isoenzymes needs further clarification.…”

Section: Microorganismsmentioning

confidence: 99%

Electrophoresis

Strickland¹

1970

Anal. Chem.

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Section: Microorganismsmentioning

confidence: 99%

Electrophoresis

Strickland¹

1970

Anal. Chem.

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Marsupial and monotreme lactate dehydrogenase isozymes: Phylogeny, ontogeny, and homology eutherian mammals

1973

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Lactate dehydrogenase (LDH) isozymes have been examined from tissues of mammalian species representative of the five families of marsupials and of the monotremes. Immunochemical, molecular hybridization, and tissue distribution studies showed that three genes (A, B and C) are responsible for LDH synthesis giving rise to five major isozymes in most tissues (LDHs &, A&, A2B2, A1B3, and B4) and an additional isozyme (LDH-C4) which is present only in mature testes. The LDH phenotypes of 93 erythrocyte samples from 31 marsupial and 2 monotreme species were analysed. Although the isozymic composition varied markedly within the marsupial families Macropodidae and Phalangeridae, the Dasyuridae showed remarkable uniformity, containing only LDH-b. The two monotreme species analysed also exhibited this latter phenotype in their erythrocytes. Ontogenic studies of the LDH isozymes of pouch young from Macropus parryi (pretty-face wallaby) showed changes similar to those reported for the developing mammalian fetus in utero. The immature pouch young exhibited similar tissue patterns of LDH isozymes which diverged during growth in the pouch thus reflecting differential genetic activity. A comparison of the relative maturity of the eutherian fetus with marsupial pouch young may be made. From these observations, it is concluded that a high degree of correlation exists among the properties of eutherian, marsupial, and monotreme LDH isozymes.

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Aldehyde dehydrogenase of the Mongolian gerbil, Meriones unguiculatus

Simpson

Lindahl

1979

J. Exp. Zool.

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The aldehyde dehydrogenase (Aldehyde:NAD(P) oxidoreductase E.C. 1.2.1.3. and 1.2.1.5) phenotype in several tissues of the Mongolian gerbil, Meriones unguiculatus, has been established. The tissue distribution of gerbil aldehyde dehydrogenase is similar to that of the rat, with liver possessing the majority of the aldehyde dehydrognease activity. Male kidney and testis possess significantly more activity than female kidney and ovary. The substrate and co-enzyme specificity of gerbil liver aldehyde dehydrogenase is also similar to that of rat and mouse liver. Gel isoelectric focusing resolves one major gerbil liver aldehyde dehydrogenase isozyme at pI 5.3. Mouse liver is resolved into two major isozymes at pIs 5.3 and 5.6 and rat liver aldehyde dehydrogenase into one major isozyme at pI 5.4. Gerbil liver aldehyde dehydrogenase is functional over a broad pH range with an optima at pH 9.0. Rat and mouse liver aldehyde dehydrogenase possess sharp pH optima at pH 8.5.

show abstract

Phylogenetic relationships of rodents on the basis of isoenzymes of lactate dehydrogenase

Cited by 16 publications

References 28 publications

Electrophoresis

Electrophoresis

Marsupial and monotreme lactate dehydrogenase isozymes: Phylogeny, ontogeny, and homology eutherian mammals

Aldehyde dehydrogenase of the Mongolian gerbil, Meriones unguiculatus

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