Physical activity and alpha-lipoic acid modulate inflammatory response through changes in thiol redox status

Zembroń-Łacny, Agnieszka; Gajewski, Michał; Naczk, Mariusz; Dziewiecka, Hanna; Siatkowski, Idzi

doi:10.1007/s13105-012-0221-8

Cited by 11 publications

(9 citation statements)

References 23 publications

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“…Recently, it has been reported that physical exercise suppressed hyperphagia in obese animals by reducing hypothalamic IKK␤/NF-B and endoplasmic reticulum stress activation through IL-6 and IL-10 anti-inflammatory activity (31). The IL-6/IL-10 anti-inflammatory axis induced by exercise was observed in different models of rodents and humans (7,22,29,45). In the present study, we observed that exercise diminished hypothalamic PTP1B protein levels through the anti-inflammatory effects of IL-6 in obese rats.…”

Section: Discussionmentioning

confidence: 99%

Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats

Chiarreotto-Ropelle

Pauli

Katashima

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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Hypothalamic inflammation is associated with insulin and leptin resistance, hyperphagia, and obesity. In this scenario, hypothalamic protein tyrosine phosphatase 1B (PTP1B) has emerged as the key phosphatase induced by inflammation that is responsible for the central insulin and leptin resistance. Here, we demonstrated that acute exercise reduced inflammation and PTP1B protein level/activity in the hypothalamus of obese rodents. Exercise disrupted the interaction between PTP1B with proteins involved in the early steps of insulin (IRβ and IRS-1) and leptin (JAK2) signaling, increased the tyrosine phosphorylation of these molecules, and restored the anorexigenic effects of insulin and leptin in obese rats. Interestingly, the anti-inflammatory action and the reduction of PTP1B activity mediated by exercise occurred in an interleukin-6 (IL-6)-dependent manner because exercise failed to reduce inflammation and PTP1B protein level after the disruption of hypothalamic-specific IL-6 action in obese rats. Conversely, intracerebroventricular administration of recombinant IL-6 reproduced the effects of exercise, improving hypothalamic insulin and leptin action by reducing the inflammatory signaling and PTP1B activity in obese rats at rest. Taken together, our study reports that physical exercise restores insulin and leptin signaling, at least in part, by reducing hypothalamic PTP1B protein level through the central anti-inflammatory response.

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Section: Discussionmentioning

confidence: 99%

Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats

Chiarreotto-Ropelle

Pauli

Katashima

et al. 2013

American Journal of Physiology-Endocrinology and Metabolism

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“…Both lipoic and dihydrolipoic acids have direct ROS quenching actions but also metal-chelating ability [40]. Supplementation of αLA (1,200 mg/day for 10 days prior to exercise) in athletes reduces inflammatory cytokines through changes in thiol redox status [41].…”

Section: Dietary Vs Supplemental Antioxidants: Same Effectiveness?mentioning

confidence: 99%

Exercise and oxidative stress: Potential effects of antioxidant dietary strategies in sports

et al. 2015

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“…Alpha‐lipoic acid (ALA)—an essential cofactor of several mitochondrial bioenergetic enzymes—is a short‐chain fatty acid with antioxidant and anti‐inflammatory properties . Although some studies have suggested that ALA could modulate inflammation, the data available in NAFLD is limited, and most of the studies have been conducted in animal models. Furthermore, contradictory results have been reported in this regard.…”

Section: What Is Known and Objectivementioning

confidence: 99%

The effect of alpha-lipoic acid on inflammatory markers and body composition in obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial

2018

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Summary What is known and objective Non‐alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury. Some animal studies suggest that alpha‐lipoic acid (ALA) can improve disease outcome. The aim of this study was to investigate the effects of ALA supplementation on liver enzymes and inflammatory markers in obese patients with NAFLD. Methods In the current randomized, double‐blind, placebo‐controlled clinical trial, 50 obese patients with NAFLD were randomly allocated to either “ALA”(received 1200 mg ALA as two capsules per day plus 400 mg vitamin E) or “placebo”(received placebo containing starch, as two capsules per day plus 400 mg vitamin E) groups for 12 weeks. Body composition and anthropometric measures, serum levels of liver enzymes, adiponectin, interleukin‐6 (IL‐6), monocyte chemoattractant protein‐1 (MCP‐1) and ferritin were measured at baseline and the end of the study. Results and discussion A total number of 45 patients completed the study (ALA group = 23; placebo group = 22). The serum concentration of IL‐6 decreased significantly in ALA group in comparison with the placebo group, at end of the study (P = 0.049). Furthermore, ALA intake resulted in a significant increase in serum adiponectin levels compared to placebo (P = 0.008). A significant improvement was observed in liver steatosis grade of the patients in both groups, compared to baseline (P < 0.05). However, there was no difference between the two groups for the changes in liver steatosis, by the end of the study. Body composition and anthropometric measures, liver enzymes, MCP‐1 and ferritin serum levels were not significantly different between the study groups, neither at the baseline nor at the end of the study. What is new and conclusion Collectively, ALA supplementation improved serum adiponectin and IL‐6 levels, without changing serum liver enzymes and liver steatosis in obese patients with NAFLD.

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Physical activity and alpha-lipoic acid modulate inflammatory response through changes in thiol redox status

Cited by 11 publications

References 23 publications

Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats

Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats

Exercise and oxidative stress: Potential effects of antioxidant dietary strategies in sports

The effect of alpha-lipoic acid on inflammatory markers and body composition in obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial

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