Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study

Liu, Xiang; Johnson, Suzanne Bennett; Lynch, Kristian; Cordan, Kerry; Pate, Russell R.; Butterworth, Martha; Lernmark, Åke; Hagopian, William; Rewers, Marian J.; McIndoe, Richard; Toppari, Jorma; Ziegler, Anette‐G.; Akolkar, Beena; Krischer, Jeffrey P.; Yang, Jimin

doi:10.2337/dc23-0036

Cited by 10 publications

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If time passes with no diagnosis of stage 3 type 1 diabetes, cognitions about type 1 diabetes may change and individuals may become convinced they will never get the disease or have reduced risk, despite evidence to the contrary [137]. Parents often engage in behaviours in attempts to prevent type 1 diabetes when faced with the news that their child is at increased risk, even when not provided with recommendations to do so, though more-recent data have shown that lower physical activity and meal plans with a higher glycaemic index are associated with faster progression to type 1 diabetes [138][139][140]. Meal-planning changes are most commonly reported, with extra monitoring at home (including blood glucose checking) being particularly common in families with someone who already has type 1 diabetes [141,142].…”

Section: Psychosocial Supportmentioning

confidence: 99%

Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes

Phillip,

Achenbach,

Addala

et al. 2024

Diabetologia

Self Cite

View full text Add to dashboard Cite

Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay disease progression, type 1 diabetes screening programmes are being increasingly emphasised. Once broadly implemented, screening initiatives will identify significant numbers of islet autoantibody-positive (IAb+) children and adults who are at risk of (confirmed single IAb+) or living with (multiple IAb+) early-stage (stage 1 and stage 2) type 1 diabetes. These individuals will need monitoring for disease progression; much of this care will happen in non-specialised settings. To inform this monitoring, JDRF in conjunction with international experts and societies developed consensus guidance. Broad advice from this guidance includes the following: (1) partnerships should be fostered between endocrinologists and primary-care providers to care for people who are IAb+; (2) when people who are IAb+ are initially identified there is a need for confirmation using a second sample; (3) single IAb+ individuals are at lower risk of progression than multiple IAb+ individuals; (4) individuals with early-stage type 1 diabetes should have periodic medical monitoring, including regular assessments of glucose levels, regular education about symptoms of diabetes and DKA, and psychosocial support; (5) interested people with stage 2 type 1 diabetes should be offered trial participation or approved therapies; and (6) all health professionals involved in monitoring and care of individuals with type 1 diabetes have a responsibility to provide education. The guidance also emphasises significant unmet needs for further research on early-stage type 1 diabetes to increase the rigour of future recommendations and inform clinical care. Graphical Abstract

show abstract

Section: Psychosocial Supportmentioning

confidence: 99%

Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes

Phillip,

Achenbach,

Addala

et al. 2024

Diabetologia

Self Cite

View full text Add to dashboard Cite

show abstract

“… 55 The screening effort also allow the identification of stage 1 individuals to develop methods to prevent them from progressing to stage 2. The screening effort should also include stage 2 type 1 diabetes individuals who would be eligible to life style intervention 56 or FDA approved Teplizumab treatment 57 to delay the onset of stage 3 type 1 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Childhood screening for type 1 diabetes comparing automated multiplex Antibody Detection by Agglutination-PCR (ADAP) with single plex islet autoantibody radiobinding assays

Lind,

Freyhult,

de Jesus Cortez

et al. 2024

eBioMedicine

Self Cite

View full text Add to dashboard Cite

Day Care Attendance and Risk of Type 1 Diabetes

Tall,

Virtanen,

Knip

2024

JAMA Pediatr

View full text Add to dashboard Cite

ImportanceA meta-analysis published in 2001 suggested that exposure to infections measured by day care attendance may be important in the pathogenesis of type 1 diabetes. Several new studies on the topic have since been published.ObjectiveTo investigate the association between day care attendance and risk of type 1 diabetes and to include all available literature up to March 10, 2024.Data SourcesData from PubMed and Web of Science were used and supplemented by bibliographies of the retrieved articles and searched for studies assessing the association between day care attendance and risk of type 1 diabetes.Study SelectionStudies that reported a measure of association between day care attendance and risk of type 1 diabetes were included.Data Extraction and SynthesisDetails, including exposure and outcome assessment and adjustment for confounders, were extracted from the included studies. The multivariable association with the highest number of covariates, lowest number of covariates, and unadjusted estimates and corresponding 95% CIs were extracted. DerSimonian and Laird random-effects meta-analyses were performed and yielded conservative confidence intervals around relative risks.Main Outcomes and MeasuresThe principal association measure was day care attendance vs no day care attendance and risk of type 1 diabetes.ResultsSeventeen articles including 22 observational studies of 100 575 participants were included in the meta-analysis. Among the participants, 3693 had type 1 diabetes and 96 882 were controls. An inverse association between day care attendance and risk of type 1 diabetes was found (combined odds ratio, 0.68; 95% CI, 0.58-0.79; P &lt; .001; adjusted for all available confounders). When the 3 cohort studies included were analyzed separately, the risk of type 1 diabetes was 15% lower in the group attending day care; however, the difference was not statistically significant (odds ratio, 0.85; 95% CI, 0.59-1.12; P = .37).Conclusions and RelevanceThese results demonstrated that day care attendance appears to be associated with a reduced risk of type 1 diabetes. Increased contacts with microbes in children attending day care compared with children who do not attend day care may explain these findings. However, further prospective cohort studies are needed to confirm the proposed association.

show abstract

Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study

Cited by 10 publications

References 39 publications

Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes

Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes

Childhood screening for type 1 diabetes comparing automated multiplex Antibody Detection by Agglutination-PCR (ADAP) with single plex islet autoantibody radiobinding assays

Day Care Attendance and Risk of Type 1 Diabetes

Contact Info

Product

Resources

About