Physical Exercise for Patients Undergoing Hematopoietic Stem Cell Transplantation: Systematic Review and Meta-Analyses of Randomized Controlled Trials

Abstract

The results suggest that recipients of HSCT may benefit from physical exercise.

Exercise for People with Cancer: A Clinical Practice Guideline

“…Fourteen systematic reviews found an improvement in qol for patients with cancer participating in an exercise intervention during the active treatment or post-treatment period 11,13,[15][16][17][18][19][20][21][22][23][24][25][26][27][28] . Of the sixteen studies involving patients in active treatment [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] , six demonstrated that, compared with the control group, the intervention group experienced significant improvements in qol 30,31,33,[38][39][40]43 .…”

Effect of physical exercise on muscle mass and strength in cancer patients during treatment—A systematic review

“…[45] This review found six trials conducted in patients with hematological malignances undergoing hematopoietic stem cell transplant (HSCT) and high dose chemotherapy, and only one trial [35] conducted in cancer patients with advanced disease. Muscle wasting is a common symptom, reported in more than 60 % of patients with advanced cancer [14] and patients with hematological malignancies undergoing stem cell transplants [46]. For both groups there is a need for treatment strategies that contribute to reduce side-effect of treatment, maintain muscle mass and strength in order to maintain quality of life, and prolong survival.…”

Changing the Way We Approach Rehabilitation in Bone Marrow Transplantation

“…In other cancer populations, such as breast and prostate cancer, there is a large body of strong evidence supporting the efficacy of exercise training [6]. Specifically in alloBMT, there is a relatively small number of studies to date [7], although these also suggest that structured exercise training is safe and may be associated with improvements in fatigue and HRQoL [7]. The majority of studies have focused on structured exercise training, including a combination of aerobic and resistance training, following completion of BMT [7].…”

“…Specifically in alloBMT, there is a relatively small number of studies to date [7], although these also suggest that structured exercise training is safe and may be associated with improvements in fatigue and HRQoL [7]. The majority of studies have focused on structured exercise training, including a combination of aerobic and resistance training, following completion of BMT [7]. We believe there is a need to extend the scope of exercise delivery to focus on 1) a broader perspective of physical activity behaviour and 2) widen the delivery of exercise intervention to commence as early as possible pre-BMT and continue both during and after hospitalisation.…”