Physical exercise improves plasmatic levels of IL-10, left ventricular end-diastolic pressure, and muscle lipid peroxidation in chronic heart failure rats

Abstract

Chronic heart failure (CHF) is characterized by left ventricular dysfunction, resulting in hemodynamic changes, sustained inflammatory state, as well as increase in oxidative stress. Physical exercise has been described as an important nonpharmacological procedure in the treatment of CHF, contributing to the improvement of the clinical outcomes in this disease. This study evaluated the effects of physical training on hemodynamics, muscle lipid peroxidation, and plasmatic levels of IL-10 in CHF rats. The left coronary artery was ligated to induce CHF, or sham operation was performed in control groups. Rats were assigned to one of four groups: trained CHF (T-CHF, n = 10), sedentary CHF (S-CHF, n = 10), trained sham (T-Sham, n = 10), or sedentary sham (S-Sham, n = 10). Trained animals had carried out a swimming protocol, 60 min/day, 5 days/wk, during 8 wk, whereas sedentary animals remained without training. Eight weeks of physical training promoted an improvement of diastolic function represented by a reduction of the left ventricular end-diastolic pressure in the T-CHF group compared with the S-CHF group (P < 0.05). Lipid peroxidation evaluated in gastrocnemius muscle using thiobarbituric acid reactive substance assay was higher in the S-CHF group compared with all other groups (P < 0.05). However, there were no differences between T-CHF compared with S-Sham and T-Sham groups. The plasmatic levels of IL-10 were lower in the S-CHF group compared with all other groups (P < 0.05). These findings demonstrate that regular physical training using a swimming protocol, with duration of 8 wk, improves the cardiac function and the anti-inflammatory response and reduces muscle cellular damage.

The Effect of an Eight-Week Rope Skipping Exercise Program on Interleukin-10 and C-Reactive Protein in Overweight and Obese Adolescents

“…Before exercise the IL-10 levels are lower; so, the regular exercise with a moderate intensity reduces proinflammatory cytokines such as IL-6 and increases anti-inflammatory cytokine such as IL-10 (12). Nunes et al (34) reported that endurance safety impacts cause a significant increase in serum IL-10 concentrations in blood that is consistent with the results of the present study. Hirose et al (35) stated that the activities that performed resistive eccentric cause a significant increase in serum IL-10.…”

Respiratory muscle training improves hemodynamics, autonomic function, baroreceptor sensitivity, and respiratory mechanics in rats with heart failure

“…In the present study, the infarcted area was ϳ45%, which is associ- ated with severe impairment of the hemodynamic function, respiratory system mechanics, and neurohumoral excitation. In a previous study developed in our laboratory (38), we demonstrated a reduction of 12% in LVEDP in rats with MI submitted to a swimming protocol compared with sedentary MI rats. However, regarding RMT, the few existing studies used only normal rats and showed positive effects of RMT on morphometric and functional characteristics of the diaphragm (4,42).…”

Vascular redox imbalance in rats submitted to chronic exercise

“…13 A decreased lipid peroxidation on gastrocnemius muscle from rats with chronic heart failure submitted to swimming training for 8 weeks was also demonstrated. 14 trained rats are more resistant to oxidative stress challenge, which is seen by a lower erythrocytes lipoperoxidation in a model of exercise damage induction. 15 Exercise training was able to inhibit the increase in muscle homogenate carbonyl content, induced by iron sulfate and ascorbic acid, in old rats.…”