Physico-Chemical and Various Spectral Investigations of Copper (II) Complex of Glimepiride, An Oral Active and Highly Potent Antidiabetic Agent

Abstract

The synthesis and characterization of a copper complex with glimepiride (an oral antidiabetic drug) has been studied. The conductometric titration using monovariation method indicates that complex is non-ionic and of ML 2 type.Analytical data agrees with the molecular formula (C 24 H 34 N 4 O 5 S) 2 Cu. Structure of the complex was assigned as square planar in which ligand molecules lies horizontally joining the central copper atom. Infrared, Mass spectral and particle size analysis had confirm the coordination of sulphonyl oxygen on one side and enolic oxygen attached from other side with the metal ion. The structure for complex was proposed on the basis of analytical data and elemental analysis.