Physicochemical and pharmacological characterization of α-tocopherol-loaded nano-emulsion system

Hatanaka, Junya; Chikamori, Hina; Sato, Hideyuki; Uchida, Shinya; Debari, Kazuhiro; Onoue, Satomi; Yamada, Shizuo

doi:10.1016/j.ijpharm.2010.06.017

Cited by 130 publications

(49 citation statements)

References 34 publications

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“…Where PCS gives the hydrodynamic radius of the suspended oil droplets, electron microscopy aids direct visualization of the sample morphology, accurate measurement of the size of the oil droplets, and presence of any other type of contaminants in the formulation. EM, for e.g., shows the presence of a small population of large-size oil droplets that could not be detected by PCS measurement (87). Transmission electron microscopy (TEM) is largely the most exploited technique for imaging of nanoemulsions where the sample is coated onto a formavar-coated copper grid and imaged under an electron beam.…”

Section: Oil Droplet Morphology Assessmentmentioning

confidence: 99%

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

et al. 2014

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Abstract. Nanoemulsion dosage form serves as a vehicle for the delivery of active pharmaceutical ingredients and has attracted great attention in drug delivery and pharmacotherapy. In particular, nanoemulsions act as an excellent vehicle for poorly aqueous soluble drugs, which are otherwise difficult to formulate in conventional dosage forms. Nanoemulsions are submicron emulsions composed of generally regarded as safe grade excipients. Particle size at the nanoscale and larger surface area lead to some very interesting physical properties that can be exploited to overcome anatomical and physiological barriers associated in drug delivery to the complex diseases such as cancer. Along these lines, nanoemulsions have been engineered with specific attributes such as size, surface charge, prolonged blood circulation, target specific binding ability, and imaging capability. These attributes can be tuned to assist in delivering drug/imaging agents to the specific site of interest, based on active and passive targeting mechanisms. This review focuses on the current state of nanoemulsions in the translational research and its role in targeted cancer therapy. In addition, the production, physico-chemical characterization, and regulatory aspects of nanoemulsion are addressed.

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Section: Oil Droplet Morphology Assessmentmentioning

confidence: 99%

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

et al. 2014

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“…Thus, it has been reported that the bioavailability of drug could be highly influenced by the formulation type (Taha et al, 2007). Nano-emulsions in pharmacy generally improves the solubility and permeability for highly lipophilic drugs for using in the nutrition field and then bioavailability enhancement has been reported (Brusewitz et al, 2007;Hatanaka et al, 2010;Kang et al,2002;Solans et al, 2005). Considering significant increment of Cmax and AUC, LaVita could be more effective the absorption rate and extent for bioavailability of vitamin A, D & E than those of general product.…”

Section: Plasma Concentration and Pharmacokinetic Analysismentioning

confidence: 99%

“…Nano-emulsions were proposed for application in pharmacy as delivery systems of poorly permeable and highly lipophilic drugs for enhancing solubility and permeation properties (Brusewitz et al, 2007;Gutierrez et al, 2008;Hatanaka et al, Solans et al, 2005;Tadros et al, 2004). Enhancement of bioavailability by solubilization of lipophilic drugs in nano-emulsion has been reported and then in vivo and in vitro studies confirmed that nanoemulsion enhanced the penetration of vitamin E acetate (Kang et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Characterization of Nano-emulsion Vitamin A, D and E (LaVita) in Rats

Lee¹,

Kwon²,

Kim³

et al. 2011

Korean Journal of Environmental Agriculture

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BACKGROUND:Bioavailability enhancement by solubilization of lipophilic drugs in nano-emulsion has been reported and it may be useful in pharmaceutical and nutraceutical products. This study was performed to compare in vivo bioavailability of nano-emulsion formulation with that of the general product as control. METHODS AND RESULTS:The pharmacokinetics assessment of Vitamin A, D and E complex of nanoemulsion formulation (LaVita), in comparison to the general product, was performed in the male rat plasma by a single oral dose at 20 mL/kg body weight (n=3/group). For nano-emulsion formulation (LaVita), C max of vitamin A and E in plasma were much higher and the area under the curve (AUC) of vitamin A, D and E were 14-63% higher, and the half-life of vitamin E was 2-fold longer than the general product. According to statistical analysis, each C max of vitamin A, D & E was significantly higher (p<0.01, 0.05 and 0.01, respectively) than that of general product. Half-life of vitamin A was significantly higher (p<0.01) and AUC of vitamin A and D were also significantly higher than the general product. CONCLUSION(s): Considering significant increment of C max and AUC, LaVita made of nano-emulsion could be more effective the absorption rate and extent for bioavailability of vitamin A, D & E than those of general product.

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“…68 In another study, alpha-tocopherol-loaded nanoemulsions with various particle sizes showed improved protective behavior in various organs, especially in streptozotocin-induced diabetic rat model. 16 Similarly, many other phyto-derived bioactive compounds, including curcumin or quercetin, have shown an enhanced bioavailability through nanoemulsion delivery systems. A curcumin-encapsulated nanoemulsion was prepared with a particle size of ~130 nm, and it showed improved oral bioavailability in addition to liver protection.…”

Section: Nanoemulsionsmentioning

confidence: 99%

“…16 Baicalin successfully formulated nanostructured lipid carrier (NLC) delivery systems with particle sizes of 92 nm, and these showed a higher antidiabetic activity with a sustained release of these compounds through oral delivery. 17 Stevioside is another phyto compound that has shown improved antidiabetic activity via controlled release of the compounds through polyethylene glycol-polylactic acid nanoparticle delivery systems with a particle size of 150 nm.…”

Section: Introductionmentioning

confidence: 99%

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

Ganesan¹,

Arulselvan²,

Choi³

2017

IJN

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Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and it is characterized by an increase in blood glucose, disturbances in the metabolism, and alteration in insulin secretion. Nowadays, food-based therapy has become an important treatment mode for type 2 diabetes, and phytobioactive compounds have gained an increasing amount of attention to this end because they have an effect on multiple biological functions, including the sustained secretion of insulin and regeneration of pancreatic islets cells. However, the poor solubility and lower permeability of these phyto products results in a loss of bioactivity during processing and oral delivery, leading to a significant reduction in the bioavailability of phytobioactive compounds to treat T2DM. Recently, nanotechnological systems have been developed for use as various types of carrier systems to improve the delivery of bioactive compounds and thus obtain a greater bioavailability. Furthermore, carrier systems in most nanodelivery systems are highly biocompatible, with nonimmunologic behavior, a high degree of biodegradability, and greater mucoadhesive strength. Therefore, this review focuses on the various types of nanodelivery systems that can be used for phytobioactive compounds in treating T2DM with greater antidiabetic effects. There is also additional focus on improving the effects of various phytobioactive compounds through nanotechnological delivery to ensure a highly efficient treatment of type 2 diabetes.

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Physicochemical and pharmacological characterization of α-tocopherol-loaded nano-emulsion system

Cited by 130 publications

References 34 publications

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

Pharmacokinetic Characterization of Nano-emulsion Vitamin A, D and E (LaVita) in Rats

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

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Physicochemical and pharmacological characterization of α-tocopherol-loaded nano-emulsion system

Cited by 130 publications

References 34 publications

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

Pharmacokinetic Characterization of Nano-emulsion Vitamin A, D and E (LaVita) in Rats

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus &ndash; current status

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Product

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Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status