Physicochemical Characterisation of Polysaccharides from the Seeds and Leaves of Miracle Fruit (<i>Synsepalum dulcificum</i>) and Their Antioxidant and <i>α</i>-Glucosidase Inhibitory Activities In Vitro

Jian, Huajun; Qiao, Fang; Chen, Jie; He, Nongyue

doi:10.1155/2017/8948639

Cited by 14 publications

(10 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(), a group of carbohydrates found in Pu‐erh tea polysaccharides can inhibit α‐glucosidase as well. The inhibition rate of tea polysaccharides was also found to be dependent upon the proportion of low molecular weight polysaccharides which had higher inhibition efficiency than the high molecular weight polysaccharides in green and Oolong teas (Jian et al ., ).…”

Section: Resultsmentioning

confidence: 97%

Effects of polysaccharides and polyphenolics fractions of Zijuan tea (Camellia sinensis var. kitamura) on α‐glucosidase activity and blood glucose level and glucose tolerance of hyperglycaemic mice

Chen

Sun

Dong

et al. 2018

Int J of Food Sci Tech

View full text Add to dashboard Cite

Summary The effects of polysaccharides, theaflavins, thearubigins and theabrownin fractions of Zijuan tea on α‐glucosidase and blood glucose level and intolerance of hyperglycaemic mice were evaluated. The polysaccharides or theaflavins fraction exhibited greater inhibition rate of α‐glucosidase than acarbose positive control, thearubigins fraction or theabrownin fraction. The four fractions were delivered to the treatment mice through oval gavage each day for 15 days. The mice in polysaccharides and theaflavins high‐ and low‐dose and theabrownin high‐dose treatments significantly lowered their blood glucose levels while all the treatment mice gained body weight. The mice in polysaccharides, theaflavins and theabrownin high‐ and low‐dose treatments had greater glucose tolerance as well. Thus, the theaflavins and polysaccharides fractions of Zijuan tea effectively moderated the complications of hyperglycaemic mice. The lower effectiveness of thearubigins and theabrownin fractions may be caused by the highly polymerised polyphenolics which decreased their accessibility to α‐glucosidase and digestibility in mice.

show abstract

Section: Resultsmentioning

confidence: 97%

Effects of polysaccharides and polyphenolics fractions of Zijuan tea (Camellia sinensis var. kitamura) on α‐glucosidase activity and blood glucose level and glucose tolerance of hyperglycaemic mice

Chen

Sun

Dong

et al. 2018

Int J of Food Sci Tech

View full text Add to dashboard Cite

show abstract

“…The stem of miracle fruit also contains antioxidant and an antityrosinase effect, which can have a potential application in food supplements and medical cosmetology [18]. Besides antioxidants, the polysaccharides from the miracle fruit leaf have been characterized to have an α-glucosidase inhibitory activity that was remarkably higher than acarbose (antidiabetic drug), which has highlighted its potential as an anti-diabetic agent [19]. The low levels of crude fat [20] and sugar content (5.6 g/100 g FW) [15] in the pulp of miracle fruit indicate that it may be healthy for human consumption, especially for patients suffering from diabetes and obesity.…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of Lactococcus lactis Gh1 with Gum Arabic and Synsepalum dulcificum via Spray Drying for Potential Inclusion in Functional Yogurt

et al. 2019

View full text Add to dashboard Cite

There has been an explosion of probiotic incorporated based product. However, many reports indicated that most of the probiotics have failed to survive in high quantity, which has limited their effectiveness in most functional foods. Thus, to overcome this problem, microencapsulation is considered to be a promising process. In this study, Lactococcus lactis Gh1 was encapsulated via spray-drying with gum Arabic together with Synsepalum dulcificum or commonly known as miracle fruit. It was observed that after spray-drying, high viability (~109 CFU/mL) powders containing L. lactis in combination with S. dulcificum were developed, which was then formulated into yogurt. The tolerance of encapsulated bacterial cells in simulated gastric juice at pH 1.5 was tested in an in-vitro model and the result showed that after 2 h, cell viability remained high at 1.11 × 106 CFU/mL. Incubation of encapsulated cells in the presence of 0.6% (w/v) bile salts showed it was able to survive (~104 CFU/mL) after 2 h. Microencapsulated L. lactis retained a higher viability, at ~107 CFU/mL, when incorporated into yogurt compared to non-microencapsulated cells ~105 CFU/mL. The fortification of microencapsulated and non-microencapsulated L. lactis in yogurts influenced the viable cell counts of yogurt starter cultures, Lactobacillus delbrueckii subs. bulgaricus and Streptococcus thermophilus.

show abstract

“…DPPH and ABTS Radical Scavenging Activity. DPPH method is often used; meanwhile, it is an easy and rapid way to evaluate the free radical scavenging activity of polysaccharide and other natural compounds, as DPPH radicals are stable at room temperature but can be easily scavenged by antioxidants [15]. As shown in Figure 1(a), the SMP and positive control (Vitamin C) showed scavenged activities on DPPH radicals.…”

Section: Resultsmentioning

confidence: 99%

The Antioxidant Polysaccharide from Semiaquilegia adoxoides (DC.) Makino Adjusts the Immune Response of Mice Infected by Bacteria

Yang

Guo

Tariq

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Semiaquilegia adoxoides (DC.) Makino is a herbal medicine and it is recorded that its water extract can be used to treat acute diseases caused by bacterial infections. In order to understand the polysaccharide of Semiaquilegia adoxoides (DC.) Makino (SMP), FT-IR and HPLC methods were performed to determine the basic chemical structure and monosaccharide compositions of SMP. The antioxidant capacity of SMP was analyzed by monitoring both the scavenging rate of DPPH and ABTS free radical. To investigate the effects of SMP on the acute bacterial disease, minimum inhibitory concentrations (MICs) of SMP on E. coli or S. aureus were detected; meanwhile, mice were administrated with SMP for 7 days and then infected with E. coli or S. aureus, and the parameters were measured at the 9th day. Results showed that SMP was a furanose which was mainly composed of glucose (60.3%) and had certain antioxidant activities. Both MIC values of SMP on E. coli and S. aureus were 250 ml/mL, which means that SMP has no direct antibacterial effects. The mice experiments revealed that SMP had potential effects on immunomodulatory by reducing WBC and the expression of serum IL-1, IL-6, and TNF-α and increasing IgM of E. coli or S. aureus infected mice. These findings supported the effect of Semiaquilegia adoxoides (DC.) Makino in folk use with scientific evidence.

show abstract

Physicochemical Characterisation of Polysaccharides from the Seeds and Leaves of Miracle Fruit (Synsepalum dulcificum) and Their Antioxidant and α-Glucosidase Inhibitory Activities In Vitro

Cited by 14 publications

References 35 publications

Effects of polysaccharides and polyphenolics fractions of Zijuan tea (Camellia sinensis var. kitamura) on α‐glucosidase activity and blood glucose level and glucose tolerance of hyperglycaemic mice

Effects of polysaccharides and polyphenolics fractions of Zijuan tea (Camellia sinensis var. kitamura) on α‐glucosidase activity and blood glucose level and glucose tolerance of hyperglycaemic mice

Microencapsulation of Lactococcus lactis Gh1 with Gum Arabic and Synsepalum dulcificum via Spray Drying for Potential Inclusion in Functional Yogurt

The Antioxidant Polysaccharide from Semiaquilegia adoxoides (DC.) Makino Adjusts the Immune Response of Mice Infected by Bacteria

Contact Info

Product

Resources

About