2020
DOI: 10.3390/life10020007
|View full text |Cite
|
Sign up to set email alerts
|

Physicochemical Foundations of Life that Direct Evolution: Chance and Natural Selection are not Evolutionary Driving Forces

Abstract: The current framework of evolutionary theory postulates that evolution relies on random mutations generating a diversity of phenotypes on which natural selection acts. This framework was established using a top-down approach as it originated from Darwinism, which is based on observations made of complex multicellular organisms and, then, modified to fit a DNA-centric view. In this article, it is argued that based on a bottom-up approach starting from the physicochemical properties of nucleic and amino acid pol… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
16
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 16 publications
(16 citation statements)
references
References 280 publications
(461 reference statements)
0
16
0
Order By: Relevance
“…In opposition to the random genetic narrative, Auboeuf asserts that the prevailing gene-centric ‘top-down’ framework that originated in early Darwinism was premised on biased observations made on complex multicellular organisms. In contrast, Auboeuf argues that an alternative ‘bottom-up’ approach better fits the physicochemical properties of nucleic and amino acid polymers [ 180 ]. In that frame, the actual objective of selective fitness is meant to sustain a “bidirectional interplay between genome and phenotype that is directed towards genomic self-integrity” [ 180 ] (p. 1).…”
Section: Discussionmentioning
confidence: 99%
“…In opposition to the random genetic narrative, Auboeuf asserts that the prevailing gene-centric ‘top-down’ framework that originated in early Darwinism was premised on biased observations made on complex multicellular organisms. In contrast, Auboeuf argues that an alternative ‘bottom-up’ approach better fits the physicochemical properties of nucleic and amino acid polymers [ 180 ]. In that frame, the actual objective of selective fitness is meant to sustain a “bidirectional interplay between genome and phenotype that is directed towards genomic self-integrity” [ 180 ] (p. 1).…”
Section: Discussionmentioning
confidence: 99%
“…The mechanism of Darwinian evolution is the key to understanding the initial complex that triggers the origin of life. Darwinian evolution is a well understood phenomenon in terms of genetic variations, natural selection, heredity, and mathematical modeling, as has been shown many times [6][7][8][9][10][11][12][13]. The task here is to define the minimum number of components working on the molecular level necessary for selection to occur, so these might be utilized in the further origin of life research.…”
Section: The Mechanism Of Darwinian Evolutionmentioning
confidence: 99%
“…In the case of functional RNAs, the "rule" is just Watson-Crick base pairing. These two components: an information carrier and a functional executive component are described as genotype and phenotype, interacting in a feedback loop that maintains the genomic stability or "guiding" the outcome from genome variations [11]. The information coming from the DNA or RNA works in tandem with the structure carried by the protein or the structural/functional RNA sequence.…”
Section: The Mechanism Of Darwinian Evolutionmentioning
confidence: 99%
See 2 more Smart Citations