Physicochemical treatment of pharmaceutical process wastewater: distillation and membrane processes

Tóth, András; Gergely, Felicián; Mizsey, Péter

doi:10.3311/pp.ch.2011-2.03

Cited by 31 publications

(34 citation statements)

References 18 publications

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“…Steam demand could be further reduced with heat integration between heat exchangers. Thus with such a coupled system operational costs can be lower and environmental fines can be avoided [19].…”

Section: Simulation Of a Hybrid Systemmentioning

confidence: 99%

“…crude oil processing, process wastewater treatment, etc. ); however it has a great energy demand as a huge drawback in an environmental point of view [19][20]. In case of alcohol dehydration, pervaporation is more efficient in that range of feed concentration where distillation is very inefficient, while at higher feed water concentrations distillation is the more reasonable choice.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of pervaporation models with simulation of hybrid separation processes

Valentínyi

Mizsey

2014

Per. Pol. Chem. Eng.

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Section: Simulation Of a Hybrid Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of pervaporation models with simulation of hybrid separation processes

Valentínyi

Mizsey

2014

Per. Pol. Chem. Eng.

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“…For a pharmaceutical company, there are several possibilities to lower AOX content of the wastewater (Koczka 2009;Toth et al 2011;Seiss et al 2001). It is preferred to first examine whether the organic halogen compounds could be substituted with solvents not containing halogens (Lapkin and Constable 2008;Mizsey 1994).…”

Section: Base Case For Model Validationmentioning

confidence: 99%

“…If this is not possible, then the wastewater can be incinerated, distilled, or stripped. It is sensible to recover the solvent content of the process wastewater and use it in other manufacturing processes (Toth et al 2011;Quan et al 2010).…”

Section: Base Case For Model Validationmentioning

confidence: 99%

Comparison of air and steam stripping: removal of organic halogen compounds from process wastewaters

Toth

Mizsey

2014

Int. J. Environ. Sci. Technol.

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In the engineering practice, there are two basic alternatives of physicochemical treatment for the removal of volatile compounds from process wastewaters: stripping with air or stripping with steam. In this work, these alternatives are investigated and compared in the case of a real industrial problem that is typical for the fine chemical industry and general conclusion is drawn. The removal of the organically bound halogens, called adsorbable organically bound halogens, is investigated. The two alternatives, air and steam stripping, are first modeled in the professional software environment of ASPEN Plus Ò . The model is validated on the data of an existing air stripper for the removal of organic halogens. Same organic halogens removal is applied for the design of a steam stripper. It is proved that the steam stripping shows better operability and economic performance than the air stripping; moreover, the volatile and/or adsorbable organically bound halogen compounds can be recovered in the distillate and they can be reused improving the sustainability.

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“…[1]. The above quote clearly explains why distillation should be investigated continuously [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Separation of Process Wastewater with Extractive Heterogeneous-Azeotropic Distillation

Tóth¹,

Szanyi²,

Haáz³

et al. 2016

Hungarian Journal of Industry and Chemistry

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The application of vapour-liquid equilibria-based separation alternatives can be extraordinarily complicated for the treatment of process wastewaters containing heterogeneous-azeotropic. Despite dissimilar successfully tested methods for separation, there is possibility to get better distillation method by enabling the separation of more and more specific process wastewater. Extractive heterogeneous-azeotropic distillation (EHAD) is a new advance in treatment of fine chemical wastewater showing special features to cope with the treatment of highly non-ideal mixtures. This method combines the worth of heterogeneous-azeotropic and extractive distillations in one apparatus without addition of any extra materials. The study of the separations of ternary component process wastewater from the fine chemical industry shows both in the modelled and experimental results that EHAD can be successfully applied. The measured and modelled compositions at extreme purities, that is, close to 0% or 100%, can be different because of the inaccuracies of the modelling. This highlights the paramount importance of the experiments if special extra-fine chemicals with almost no impurities, e.g. of pharmacopoeial quality are to be produced by special distillation technique. This study expands the application of EHAD technique, this new field is the separation of process wastewaters.

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Physicochemical treatment of pharmaceutical process wastewater: distillation and membrane processes

Cited by 31 publications

References 18 publications

Comparison of pervaporation models with simulation of hybrid separation processes

Comparison of pervaporation models with simulation of hybrid separation processes

Comparison of air and steam stripping: removal of organic halogen compounds from process wastewaters

Separation of Process Wastewater with Extractive Heterogeneous-Azeotropic Distillation

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