Physiological Roles of Nerve Growth Factor in Adult Rodents: A Biobehavioral Perspective

Alleva, Enrico; Aloe, Luigi

doi:10.46867/c4601r

Cited by 27 publications

(1 citation statement)

References 64 publications

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“…En animales viejos la administración de NGF recupera la actividad de las enzimas barredoras de radicales de oxígeno y de peróxido de hidrógeno como la catalasa, la dismutasa del superóxido y la peroxidasa del glutatión (26). Por otro lado, los radicales del oxígeno, liberados por las lesiones nerviosas, inducen la expresión de los genes del NGF y del factor de crecimiento de fibroblastos tipo básico (bFGF); así pues, estos factores cumplen una función protectora de las estructuras nerviosas cercanas a la lesión (27).…”

Section: Efectos En El Snpunclassified

Factores de crecimiento IV: Factor de crecimiento epidérmico,Factores estimuladores de colonias, Neurotropinas

Maldonado

Londoño

1999

Iatreia

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En esta cuarta entrega sobre los factores de crecimiento se revisan el factor de crecimiento epidérmico (EGF), los factores estimuladores de colonias (CSF) y las neurotropinas. Como se ha venido presentando en las anteriores entregas, se hace referencia a su estructura bioquímica, su mecanismo de acción, sus efectos biológicos y sus interacciones. Las neurotropinas y el EGF, por tratarse de factores que actúan predominantemente en el microambiente tisular, no pueden manejarse en el contexto de concentraciones circulantes, situación que sí es factible para los CSF. De otro lado, se revisan los mecanismos de las neurotropinas en el sistema nervioso.

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Section: Efectos En El Snpunclassified

Factores de crecimiento IV: Factor de crecimiento epidérmico,Factores estimuladores de colonias, Neurotropinas

Maldonado

Londoño

1999

Iatreia

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Early social enrichment augments adult hippocampal BDNF levels and survival of BrdU‐positive cells while increasing anxiety‐ and “depression”‐like behavior

Branchi

D’Andrea

Sietzema

et al. 2006

J of Neuroscience Research

110

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Early experiences affect brain function and behavior at adulthood. Being reared in a communal nest (CN), consisting of a single nest where three mothers keep their pups together and share care-giving behavior from birth to weaning (postnatal day [PND] 25), provides an highly socially stimulating environment to the developing pup. Communal nest characterizes the natural ecologic niche of many rodent species including the mouse. At adulthood, CN reared mice, compared to mice reared in standard nesting laboratory condition (SN), show an increase in BDNF protein levels and longer survival of BrdU-positive cells in the hippocampus. Open field and elevated plus maze results indicate that CN mice, although showing levels of exploratory and locomotor activity similar to those of SN mice, displayed increased anxiety-like behavior, performing more thigmotaxis in the open field and spending less time in the open arms of the plus maze. Furthermore, CN mice displayed higher levels of immobility behavior in the forced swim test. Overall, these findings show that CN, an highly stimulating early social environment, increases adult neuronal plasticity, as suggested by high BDNF levels and augmented number of newly generated cells in the hippocampus, which is associated to an increased anxiety- and "depression"-like behavior. These findings are discussed in the framework of the neurotrophin hypothesis of depression.

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Genetic and Epigenetic Determinants of Aggression

Klausz

Haller

Tulogdi

et al. 2012

Patho-Epigenetics of Disease

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Physiological Roles of Nerve Growth Factor in Adult Rodents: A Biobehavioral Perspective

Cited by 27 publications

References 64 publications

Factores de crecimiento IV: Factor de crecimiento epidérmico,Factores estimuladores de colonias, Neurotropinas

Factores de crecimiento IV: Factor de crecimiento epidérmico,Factores estimuladores de colonias, Neurotropinas

Early social enrichment augments adult hippocampal BDNF levels and survival of BrdU‐positive cells while increasing anxiety‐ and “depression”‐like behavior

Genetic and Epigenetic Determinants of Aggression

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