Physiology of embryo-endometrial cross talk

Modi, Deepak; Bhartiya, Pradeep

doi:10.4103/2349-3666.240622

Cited by 21 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The interleukins IL‐6, IL‐11 and LIF are a family of gp130 cytokines, which act on their target cells by activating the JAK‐STAT pathway. The role of gp130 cytokines in trophoblast cells has been most extensively reviewed elsewhere and hence only briefly discussed here. IL‐6 and LIF stimulate the invasion of primary trophoblast and JEG‐3 choriocarcinoma cells; the involvement of IL‐11 is less clear.…”

Section: Pro‐invasive Factorsmentioning

confidence: 99%

Decidual Control of Trophoblast Invasion

Sharma

Godbole

Modi

2016

American J Rep Immunol

234

184

View full text Add to dashboard Cite

At the time of implantation, the trophoblast cells of the embryo adhere and then invade into the maternal endometrium and eventually establish placentation. The endometrium at the same time undergoes decidualization, which is essential for successful pregnancy. While the NK cells of the decidua have been implicated to play a key role in trophoblast invasion, few evidence are now available to demonstrate a pro-invasive property of decidual stromal cells. Secretions from decidualized endometrial stromal cells promote invasion of primary trophoblasts and model cell lines by activating proteases and altering expression of adhesion-related molecules. The decidual secretions contain high amounts of pro-invasive factors that include IL-1b, IL-5, IL-6, IL-7, IL-8, IL-9, IL-13, IL-15, Eotaxin CCL11, IP-10 and RANTES, and anti-invasive factors IL-10, IL-12 and VEGF. It appears that these decidual factors promote invasion by regulating the protease pathways and integrin expression utilizing the STAT pathways in the trophoblast cells. At the same time the decidua also seem to secrete some anti-invasive factors that are antagonist to the matrix metalloproteinases and/or are activators of tissue inhibitors of metalloproteinases. This might be essential to neutralize the effects of the invasionpromoting factors and restrain overinvasion. It is tempting to propose that during the course of pregnancy, the decidua must balance the production of these pro and anti-invasive molecules and such harmonizing production would allow a timely and regulated invasion.

show abstract

Section: Pro‐invasive Factorsmentioning

confidence: 99%

Decidual Control of Trophoblast Invasion

Sharma

Godbole

Modi

2016

American J Rep Immunol

234

184

View full text Add to dashboard Cite

show abstract

“…After hatching from the zona pellucida on Day 7, the porcine conceptus changes rapidly from spherical to tubular, and then filamentous form between Days 10 and 12 after ovulation [ 4 ]. This is accompanied by differentiation of trophoblast cells making the conceptus ready for implantation [ 5 ]. Maternal recognition and establishment of pregnancy in pigs requires a biphasic pattern of estrogen secretion by the conceptus, mainly 17β-estradiol (E 2 ), increased between Days 11–12 and Day 15 and Days 25–30, respectively [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…The embryo-endometrial cross-talk in the pig has evolved as a critical mechanism responding initially to the hormonal trigger in order to achieve receptivity and then amplify the decision under embryonic signals for pregnancy. Thus, the endometrium’s receptive ability and the prevention of luteolysis is very important during this critical period [ 5 ]. So far, a number of studies have been performed to analyze differential gene expression in porcine endometrium in response to embryonic signals starting from blastocyst stage [ 15 ] until placentation [ 16 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

Cell type-specific analysis of transcriptome changes in the porcine endometrium on Day 12 of pregnancy

et al. 2018

View full text Add to dashboard Cite

BackgroundAlong with trophoblast elongation (Days 10 to 12), estradiol is secreted in increasing amounts for recognition of pregnancy. Endometrial secretions driven by ovarian progesterone and conceptus signals are essential for conceptus growth and development. Results of transcriptome analyses of whole endometrial tissue samples in the pig indicated the need for cell type-specific endometrial gene expression analysis for a better understanding of transcriptome changes associated with establishment of pregnancy.ResultsThe most distinct transcriptome profile and the majority of differentially expressed genes (DEGs) were identified in luminal epithelium (LE). Many DEGs were found only in the cell type-specific analysis. The functional classification of DEGs identified in specific endometrial cell types revealed various distinct functions and pathways. Genes related to immune activation, estrogen signaling pathway, embryo development, and cell proliferation were upregulated in LE of pregnant gilts. Genes involved in sterol biosynthetic and metabolic processes and extracellular matrix were upregulated in stroma. Genes associated with cell communication such as via exosomes and vesicles were found as differential in LE, glandular epithelium (GE), and stroma (S).ConclusionsThis study revealed that conceptus signals induce different transcriptomic regulations in the endometrial compartments/cell types related to their specific function during recognition and establishment of pregnancy.Electronic supplementary materialThe online version of this article (10.1186/s12864-018-4855-y) contains supplementary material, which is available to authorized users.

show abstract

“…Traditionally, it has been assumed that the receptive endometrium is a passive tissue that should readily implant an embryo. However, several experimental evidences confirmed that during implantation there occurs an extensive cross talk between the fetal and maternal compartments [1,2]. Based on these studies, we now suggests that embryo implantation is a three-step process involving 1) gain of a receptive stage endometrium; 2) superimposition of a blastocyst-derived signature onto the receptive endometrium leading to implantation; and finally 3) breaching by the embryo and trophoblast invasion, culminating in decidualization and placentation [3].…”

Section: Introductionmentioning

confidence: 88%

Extracellular vesicle mediated embryo-endometrial cross talk during implantation and in pregnancy

Kurian

Modi

2018

J Assist Reprod Genet

112

100

View full text Add to dashboard Cite

Extracellular vesicles are lipoproteinaceous membrane-enclosed nanometer-sized structures produced by cells and are thought to mediate cellular communications. Loaded with a specific set of miRNA and protein depending on their tissue of origin, these extracellular vesicles modulate diverse set of biological processes in their target tissues. In recent years, data has gathered on the roles of extracellular vesicles in embryo implantation and pregnancy. Embryo, oviduct, endometrial epithelium and stroma/ decidua derived vesicles interact with trophoblast cells and promote their growth and differentiation to aid in embryo implantation. The placental vesicles are detected in maternal circulation that aids in feto-maternal immune tolerance, their levels vary in women with pregnancy-related complications like preeclampsia. Beyond the host, the microbes in the genital tract are also reported to produce extracellular vesicles which are thought to be responsible for inflammation and preterm births. This review focuses on the extracellular vesicular trafficking involved in success of pregnancy.

show abstract

Physiology of embryo-endometrial cross talk

Cited by 21 publications

References 0 publications

Decidual Control of Trophoblast Invasion

Decidual Control of Trophoblast Invasion

Cell type-specific analysis of transcriptome changes in the porcine endometrium on Day 12 of pregnancy

Extracellular vesicle mediated embryo-endometrial cross talk during implantation and in pregnancy

Contact Info

Product

Resources

About