Physisorption of Poly(ethylene glycol) on Inorganic Nanoparticles

Xue, Yao; Gao, Huimin; Yu, Linxiuzi; Kang, Jing; Wang, Chunyu; Lu, Zhong‐Yuan; Whittaker, Andrew K.; Liu, Kun

doi:10.1021/acsnano.2c01051

Cited by 25 publications

(11 citation statements)

References 48 publications

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“…The silica layer endows the GNRs with high thermal stability, maintaining the shape and physical properties at a polymerization temperature of 70 °C . The silica layer also circumvents potential physisorption of polymer chains to the GNRs, observed even for PEG chains, and also in this study for PMSEA chains. ζ-Potential analysis of the GNRs was performed to investigate the change in surface charge of the silica-coated GNRs at each synthetic step (Figure S1).…”

Section: Resultsmentioning

confidence: 72%

Low-Fouling Gold Nanorod Theranostic Agents Enabled by a Sulfoxide Polymer Coating

Chang

Wang

et al. 2022

Biomacromolecules

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Gold nanorods (GNRs) are widely used in various biomedical applications such as disease imaging and therapy due to their unique plasmonic properties. To improve their bioavailability, GNRs often need to be coated with hydrophilic polymers so as to impart stealth properties. Poly(ethylene glycol) (PEG) has been long used as such a coating material for GNRs. However, there is increasing acknowledgement that the amphiphilic nature of PEG facilitates its interaction with protein molecules, leading to immune recognition and consequent side effects. This has motivated the search for new classes of low-fouling polymers with high hydrophilicity as alternative low-fouling surface coating materials for GNRs. Herein, we report the synthesis, characterization, and application of GNRs coated with highly hydrophilic sulfoxide-containing polymers. We investigated the effect of the sulfoxide polymer coating on the cellular uptake and in vivo circulation time of the GNRs and compared these properties with pegylated GNR counterparts. The photothermal effect and photoacoustic imaging of these polymer-coated GNRs were also explored, and the results show that these GNRs are promising as nanotheranostic particles for the treatment of cancer.

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Section: Resultsmentioning

confidence: 72%

Low-Fouling Gold Nanorod Theranostic Agents Enabled by a Sulfoxide Polymer Coating

Chang

Wang

et al. 2022

Biomacromolecules

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“…In addition, ultrasonication can improve the grafting efficiency. As shown in literature, the grafting of thiol-terminated ligands to AuNPs is fast and the grafting density of polymer ligands can reach a high level in several minutes . Similar results were found in the grafting reaction between PMMA-TL and AuNPs, as shown in Figure S14.…”

Section: Results and Discussionmentioning

confidence: 99%

“…As shown in literature, the grafting of thiolterminated ligands to AuNPs is fast and the grafting density of polymer ligands can reach a high level in several minutes. 32 Similar results were found in the grafting reaction between PMMA-TL and AuNPs, as shown in Figure S14. When the grafting solution was treated by ultrasonication for 10 min, the grafting density of AuNP@PMMA-TL could reach 0.35 chains/nm 2 , which was almost the same as that kept undisturbed for 1 h (0.34 chains/nm 2 ).…”

Section: Optimizing the Methods For Grafting Pmma Tomentioning

confidence: 99%

Grafting of Poly(methyl methacrylate) with Different Sulfur-Containing End Groups on Gold Nanoparticles and Their Interfacial Assembly into Superlattice Films

et al. 2023

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Grafting polymer ligands on gold nanoparticles (AuNPs) by gold−sulfur (Au−S) bond is a facile way commonly employed to fabricate gold−polymer hybrid NPs (AuNP@ polymer). By using the reversible addition−fragmentation chain transfer (RAFT) radical polymerization, it is convenient to present sulfur-containing end groups to polymer ligands, such as dithioester and trithioester groups, which can be usually transferred to thiol/thiolactone/ disulfide groups by aminolysis reaction. However, these groups show different bonding effects to AuNPs. Especially for the thiolactone-terminated polymer, the weak bonding between thiolactone and AuNPs results in unstable AuNP@polymer conjugates, which further affects their assembly behavior. Here in this work, the effects of the end group on the surface-grafting of AuNPs were investigated by using poly(methyl methacrylate) (PMMA) ligands containing thiolactone/dithioester/disulfide/thiol end groups. By tuning the solvent property and the concentration of PMMA ligands, the thiolactone-terminated PMMA can be successfully grafted on the AuNPs, which has been regarded as a great challenge due to the weak bonding between gold and thiolactone. The grafting density of thiolactone-terminated PMMA can reach 0.5 chains/nm 2 , which is similar to that of disulfide/thiol-terminated PMMA. Moreover, the grafting density shows critical influence on the interfacial assembly behavior of AuNP@PMMA conjugates. By optimizing the assembly parameters, a superlattice film of AuNP@PMMA conjugates could be constructed, which may have promising applications in memory devices and sensors.

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“…PEGylation is widely used for the surface modification of inorganic nanoparticles to offer their antifouling properties for bioapplications, generally through chemical grafting-to reactions. Prof. Zhongyuan Lu, Kun Liu, and collaborators revealed the unexpected physisorption between poly(ethylene glycol) and surface ligands of nanoparticles and provided new insights into the “loop-train-tail” conformations on the nanoparticles …”

Section: Nanomaterials For Nanomedicinesmentioning

confidence: 99%

Nanoscience and Nanotechnology at Jilin University: A Virtual Issue

Liu

Zou

2022

ACS Nano

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Metrics & MoreArticle Recommendations ■ INTRODUCTION OF JILIN UNVIERSITY Jilin University (JLU) was established in 1946 and is a leading national comprehensive university of China located in Changchun, the capital of Jilin Province. JLU offers a wide range of disciplines in education and is strong at interdisciplinary research. In particular, research on nanoscience and nanotechnology is actively conducted by several top disciplines of JLU, including but not limited to Chemistry, Physics, Materials, and Electronics. This September, both the chemistry and physics disciplines (ranked in the top 0.1% and 1% of the global Essential Science Indicators, respectively) in JLU will celebrate their 70th anniversary. ■ COLLEGE OF CHEMISTRY AT JLUThe discipline of Chemistry at JLU was founded in 1952 by Profs. Liusheng Tsai, Auchin Tang, Shizhi Kuan, Weisun Tao, and many other prominent chemists. Developed in the spirit of dedication, innovation, integrity, and collaboration, the discipline of Chemistry at JLU is now internationally acclaimed for its excellence and commitment in both fundamental research and education. The College of Chemistry has placed a tremendous emphasis on high-quality education to prepare our students for both current and future challenges in chemistry and related fields. It has developed a high-level comprehensive system for undergraduate and graduate education. Many graduates from the College become academic leaders, represented by 15 members of the Chinese Academy of Sciences and Chinese Academy of Engineering. Some of the alumni are highly active in the field of nanomaterials and nanotechnology, including but not limited to Profs.

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Physisorption of Poly(ethylene glycol) on Inorganic Nanoparticles

Cited by 25 publications

References 48 publications

Low-Fouling Gold Nanorod Theranostic Agents Enabled by a Sulfoxide Polymer Coating

Low-Fouling Gold Nanorod Theranostic Agents Enabled by a Sulfoxide Polymer Coating

Grafting of Poly(methyl methacrylate) with Different Sulfur-Containing End Groups on Gold Nanoparticles and Their Interfacial Assembly into Superlattice Films

Nanoscience and Nanotechnology at Jilin University: A Virtual Issue

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