Physostigmine: Effects on fear or defense responses in the rat

Mollenauer, Sandra; White, Michael S.; Plotnik, Rod; Tiffany, P. Bradlee

doi:10.1016/0091-3057(79)90012-1

Cited by 8 publications

(1 citation statement)

References 22 publications

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“…Several papers have revealed that methylscopolamine (a drug which scarcely crosses the blood-brain barrier) was ineffective on all the behavioural patterns studied here (Janssen et al 1960;Van der Poel and Remmelts 1971;Plotnik et al 1975;Mollenauer et al 1979;Horsburgh and Hughes 1981).…”

Section: Discussionmentioning

confidence: 99%

Age-related scopolamine effects on social and individual behaviour in rats

Soffié

Bronchart

1988

Psychopharmacology

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The modulation of spontaneous (social and individual) behaviour as a function of the age of the rat (1, 3, 6, 12, 18 and 24 months) and of scopolamine dose (0.1, 0.2, 0.3 and 0.5 mg/kg) was studied. Observations were conducted during the dark phase of the reverse light/dark schedule using a reintroduction procedure. Results showed a marked effect of scopolamine on most of the behavioural patterns considered. Environmental interaction was enhanced whilst agonistic and social active interactions (social grooming) and play fighting were reduced by the drug. A slight hyposensitivity in the youngest rats and a marked hyposensitivity to the drug in the oldest ones were observed. The relationship to biochemical data and human sensitivity on the one hand and to learning and memory tasks and cholinergic specificity on the other hand, are discussed.

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Section: Discussionmentioning

confidence: 99%