Phyto-chemical and biological activity of Myristica fragrans, an ayurvedic medicinal plant in Southern India and its ingredient analysis

Al‐Qahtani, Wahidah H.; Yuvaraj, D.; Arokiyaraj, Selvaraj; Saravanakumar, Vigneshwar; Jothiramalingam, R.; Arjun, Kowsalya; Gayathri, P.K.; Appaturi, Jimmy Nelson

doi:10.1016/j.sjbs.2022.02.043

Cited by 20 publications

(6 citation statements)

References 19 publications

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“…The extract obtained via soxhlet extraction showed a significant content of β-elemene compared to that obtained via sonication (2.81 and 0.97%, respectively). The study of Al Quahtani and his collaborators, published in 2022, confirmed that β-elemene is a bioactive triterpenoid [ 18 ]. Tan and his colleagues demonstrated that β-elemene combined with an IL-23-transfected dendritic vaccine showed inhibitory effects on pancreatic cells and prolonged the survival time, representing an effective antitumor immunotherapeutic method form urine pancreatic cancer [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis and Evaluation of the Antioxidant, Antiproliferative, Antibacterial, and Antibiofilm Effects of Globularia alypum (L.) Leaves

et al. 2023

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Globularia alypum L. (GA) is a Mediterranean plant of the Globulariaceae family which is widely used in traditional Tunisian medicine. The main goal of this study was to evaluate the phytochemical composition, antioxidant, antibacterial, and antibiofilm activities, and the antiproliferative potential of different extracts of this plant. The identification and the quantification of the different constituents of extracts were determined using gas chromatography–mass spectrometry (GC-MS). The antioxidant activities were evaluated using spectrophotometric methods and chemical tests. The antiproliferative study was based on the use of colorectal cancer SW620 cells, including an antibacterial assessment with the microdilution method and analysis of the antibiofilm effects via the crystal violet assay. All extracts presented several components, mainly sesquiterpenes, hydrocarbon, and oxygenated monoterpenes. The results revealed that the maceration extract had the most important antioxidant effect (IC50 = 0.04 and 0.15 mg/mL), followed by the sonication extract (IC50 = 0.18 and 0.28 mg/mL). However, the sonication extract demonstrated significant antiproliferative (IC50 = 20 µg/mL), antibacterial (MIC = 6.25 mg/mLand MBC > 25 mg/mL), and antibiofilm (35.78% at 25 mg/mL) properties against S. aureus. The results achieved confirm the important role of this plant as a source of therapeutic activities.

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Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis and Evaluation of the Antioxidant, Antiproliferative, Antibacterial, and Antibiofilm Effects of Globularia alypum (L.) Leaves

et al. 2023

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“…Generally, the antioxidant activity corresponds to the main components of the essential oils. Elemicin is an alkenylbenzene reported with pharmacological effects as antioxidant by Surveswaran et al in 2006 [ 28 ] and the SC 50 for DPPH was minor to 100 µg/mL according to Al-Qahtani et al, 2022 [ 29 ]. On the other hand, α-bisabolol has also has been reported to have pharmacological effects, including in vivo antioxidant capacity [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Study of the Chemical Composition and Biological Activity of the Essential Oil from Congona (Peperomia inaequalifolia Ruiz and Pav.)

Valarezo

Herrera-García

Astudillo-Dávila

et al. 2023

Plants

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The species Peperomia inaequalifolia, commonly known as congona, is a succulent herbaceous plant belonging to the Piperaceae family, which is used for different purposes in traditional medicine. In this study, the chemical composition, enantiomeric distribution, and biological activity of essential oil isolated from the leaves of this species was determined. Hydrodistillation was used to isolate the essential oil. Gas chromatography coupled to mass spectrometry was used to determine the qualitative composition, a gas chromatograph equipped with a flame ionization detector was used to determine quantitative composition, and gas chromatography on an enantioselective column was used to determine enantiomeric distribution. Antibacterial activity was determined using the broth microdilution method, for which we used three Gram-positive cocci bacteria, a Gram-positive bacilli bacterium, and three Gram-negative bacilli bacteria. 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical cations and 2,2-diphenyl-1-picrylhydryl (DPPH) radicals were used as reagents for determining the antioxidant activity of the essential oil. The spectrophotometric method was used to analyze the acetylcholinesterase inhibitory effect of the essential oil. The yield of leaves in essential oil was 0.16 ± 0.01% (v/w). Forty-three chemical compounds were identified in the essential oil, which represent 97.46% of the total composition. Sesquiterpene hydrocarbons were the most representative group, with 24 compounds (21.63%). The principal constituents were found to be elemicin (27.44 ± 1.35%), bisabolol <α-> (17.76 ± 1.38), myristicin (15.45 ± 0.86), methyl eugenol (6.22 ± 0.24), viridiflorene (6.81 ± 0.10), and safrole (6.68 ± 0.23). Three pairs of enantiomers were identified in the essential oil of Peperomia inaequalifolia. Essential oil presented a minimum inhibitory concentration (MIC) of 4000 μg/mL against Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli. The antioxidant activity of the essential oil was strong according to the DPPH and ABTS methods, with a half radical scavenging capacity (SC50) of 293.76 ± 3.12 µg/mL and 226.86 ± 0.05 µg/mL, respectively. Additionally, the essential oil reported moderate anticholinesterase activity, with an IC50 of 43.93 ± 1.05 µg/mL.

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“…RA is a chronic, inflammatory, and systemic autoimmune disease [23]. Therapeutic agents against arthritis such as analgesics and NSAIDS reduce inflammation and joint destruction in either acute or chronic RA patients [24]. On the other hand, gastrointestinal ulcers, cardiovascular complications, myelosuppression, hepatic fibrosis, stomatitis, cirrhosis, nephrotoxicity, pulmonary toxicity, immunological reactions, and local injection-site reactions are among the long-term dangers associated with medication use.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, gastrointestinal ulcers, cardiovascular complications, myelosuppression, hepatic fibrosis, stomatitis, cirrhosis, nephrotoxicity, pulmonary toxicity, immunological reactions, and local injection-site reactions are among the long-term dangers associated with medication use. Furthermore, increased expenses and adverse effects, such as elevated chances of infections and miscarriages, necessitate ongoing surveillance [24]. As a result, fresh strategies are created to preserve the harmony between these possible hazards and recognized advantages [25].…”

Section: Discussionmentioning

confidence: 99%

“…Safer and more effective medications are currently being created from oriental sources for the treatment of RA. To lessen these negative effects and boost the positive effects, a wide range of herbal extracts and products, including polyherbal formulations, are created [24]. A review conducted by Choudhary et al reported that about 485 plant species would have a promising anti-arthritic activity in humans.…”

Section: Discussionmentioning

confidence: 99%

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HPLC-DAD Analysis and Investigation of Biological Properties of the Leaves of Globularia alypum (L.), Infusion Extract

Nouir,

Laouani,

Loghmari

et al. 2023

Pharmaceuticals

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Globularia alypum L. (GA) belonging to the Globulariaceae family is a Mediterranean plant which is widely used in traditional Tunisian medicine. The aim of this study was to investigate the phytochemical composition, antioxidant, anti-arthritic, antiproliferative, antibacterial and antibiofilm potential of aqueous GA leaf extracts (AGAL). Quantitative analyses of the different constituents of extracts were evaluated by high-performance liquid chromatography with photodiode-array detection (HPLC-DAD). Spectrophotometric methods and chemical tests were used for antioxidant and anti-arthritic activities. The antiproliferative study was evaluated using colorectal cancer SW620 cells, while the antibacterial assessment and analysis of the antibiofilm effects were determined by the microdilution method and the crystal violet assay, respectively. AGAL extracts presented several components, mainly Nepetin-7-Glucoside and trans-ferrulic acid. The results showed that they had an important antioxidant (IC50 = 0.34; 0.38 and 1.20 mg/mL) and anti-arthritic (IC50 = 2.94 mg/mL) properties, and these effects are displayed in a dose-dependent manner. In addition, this extract demonstrated significant antiproliferative (IC50 = 50 µg/mL), antibacterial (MIC = 6.25 mg/mL and MBC = 6.25 mg/mL), and antibiofilm (59.70% at 25 mg/mL) properties especially against S. aureus. The results achieved confirm the important role of this plant as a source of therapeutic activities.

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Phyto-chemical and biological activity of Myristica fragrans, an ayurvedic medicinal plant in Southern India and its ingredient analysis

Cited by 20 publications

References 19 publications

Phytochemical Analysis and Evaluation of the Antioxidant, Antiproliferative, Antibacterial, and Antibiofilm Effects of Globularia alypum (L.) Leaves

Phytochemical Analysis and Evaluation of the Antioxidant, Antiproliferative, Antibacterial, and Antibiofilm Effects of Globularia alypum (L.) Leaves

Study of the Chemical Composition and Biological Activity of the Essential Oil from Congona (Peperomia inaequalifolia Ruiz and Pav.)

HPLC-DAD Analysis and Investigation of Biological Properties of the Leaves of Globularia alypum (L.), Infusion Extract

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