Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model

Abstract

The results of the present study revealed that the aerial part extracts of A. mollis and A. persica could be beneficial in the treatment of endometriosis.

Effects of <i>Alchemilla mollis</i> and <i>Alchemilla persica</i> on the wound healing process

“…Hyperoside and isoquercitrin which are the major components of the aerial parts of the both species were quantified as 0.2 ± 0.002 mg and 0.6 ± 0.003 mg, respectively A. Mollis; and 0.2 ± 0.001 mg and 0.5 ± 0.001 mg respectively in A. persica for 100 mg plant material. In consequence, the phytochemical profiles of A. mollis and A. persica were found to be similar in terms of their HPLC chromatograms (Kupeli Akkol et al, 2015).…”

“…In the present study, wound healing activity of A. mollis and A. persica, both of which have quite similar phytochemical profile according to our previous research (Kupeli Akkol et al, 2015), were selected in order to be evaluated by using in vivo wound models. The extracts prepared from the aerial parts of A. mollis and A. persica displayed significant wound healing effect with regard to the contraction and tensile strength values, as well as histopathological and hydroxyproline analysis.…”

“…The most popular species of this genus is A. vulgaris L. The medicinal part of the plant is the aerial part, collected in flowering season, which is also recorded in ESCOP Monographs and approved by Commision E in order to be used against diarrhea as well as gastrointestinal complaints hemorrhoids and dysmenorrhoae and externally in the cases of stomatitis and wound healing (ESCOP Monographs, 2003;Gruenwald et al, 2000;Neagu et al, 2015). Indeed, in traditional medicine, Alchemilla species have been used internally for the treatment of menopausal complaints, dysmenorrhea, gastrointestinal disorders, mouth and throat inflammation and externally for ulcers, eczema and skin rashes (Kupeli Akkol et al, 2015). One of these species, A. mollis, is used in traditional medicine for the treatment of wounds and excessive menstruation (Makau et al, 2013;Trendafilova et al, 2011;Yarnel and Abascal, 2009).…”

Medicinal plants with wound healing potential

“…Species of Alchemilla have been reported for the treatment of dysmenorrhea, gastrointestinal disorders, inflammation of the mouth and throat, eczema and skin rashes (Kupeli Akkol et al, 2015). Alchemilla mollis is traditionally used for the treatment of wounds and excessive menstruation (Makau et al, 2013;Trendafilova et al, 2011;Yarnel and Abascal, 2009).…”

Delphinidin induces antiproliferation and apoptosis of endometrial cells by regulating cytosolic calcium levels and mitochondrial membrane potential depolarization

“…4 The first line of treatment of endometriosis is hormonal regulation along with the use of oral contraceptives for regulating the menstrual cycle, for ensuring long-term safety. 8 Likewise, numerous in vitro and in vivo studies have demonstrated the potential of certain phytochemicals to act as therapeutic adjuvants for the treatment of endometriosis. 5 Therefore, the only effective treatment for endometriosis is surgery, even though the rate of recurrence is 30% within 4 years.…”