Phytochemical analysis and antifungal activity of <i>Ganoderma lucidum</i>

Kumar, Channaveerachari Naveen; Srikumar, Ramakrishnan; Swathi, S; Chidambaram, Ranganathan; Muthukrishnan, G; Reddy, E Prabhakar

doi:10.5958/0976-5506.2018.01820.x

Cited by 4 publications

(4 citation statements)

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“…It is presumably because the active compound as an antifungal in G. Lucidum has a higher amount than the other two Ganoderma fungi. The results of this study are in line with the results of research by Kumar [17], which shows that G. lucidum has antifungal activity against Candida albicans, Aspergillus flavus, A. Fumigates, and Crytococcus neoformans. This fungus has also been used long enough as a medicine for various diseases.…”

Section: Cryptococcus Neoformanssupporting

confidence: 91%

“…This study justifies the claimed uses of G. lucidum in the traditional system of medicine and its bioactive components to treat various infectious diseases caused by the microbes. From all the above results, it is known that all three Ganoderma species contain antifungal compounds, where the antifungal compounds contained in Ganoderma include terpenoids, flavonoids, tannins, alkaloids, and steroids [18], [19], [17]. These antifungal compounds work like antibiotics.…”

Section: Cryptococcus Neoformansmentioning

confidence: 99%

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Effectiveness of Ethanol Extract among Three Ganoderma Species From Lombok in Inhibition Growth of Candida albicans and Cryptoccocus neoformans

Hidayat

Sukiman

Hidayati

et al. 2020

JoSSEd

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Candida albicans and Cryptoccocus neoformans are opportunistic pathogenic fungi that cause infectious diseases that are the world's biggest health problems. The use of antibiotics is one way to overcome the spread of the infection and cause microbial resistance. Ganoderma is one of the many macrophages found on Lombok's island, and studies of its antifungal activity have not been carried out. The purpose of this study was to determine the antifungal potential and the effect of different concentrations of ethanolic extracts of three Ganoderma species on C. albicans and C. neoformans. Ganoderma samples were obtained from Suranadi Taman Wisata Alam (TWA), Sesaot TWA, Tunak Mountain TWA, Kerandangan TWA, and Pusuk Forest. Ganoderma extraction was carried out by the maceration method using ethanol 95% solvent. The extract concentrations used are 20%, 40%, 60% and 80%. This research was conducted using the wells method with metronidazole as a positive control and 50% DMSO as a negative control. The parameter measured is the large diameter of the inhibition zone formed around the well. The results obtained are the three species of Ganoderma have antifungal activity against test fungi, and different levels of concentration affect inhibition. The amount of the inhibition zone is directly proportional to the high concentration of the extract. All three Ganoderma species are more effective in inhibiting the growth of C. neoformans compared with Candida albicans

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Section: Cryptococcus Neoformanssupporting

confidence: 91%

Section: Cryptococcus Neoformansmentioning

confidence: 99%

Effectiveness of Ethanol Extract among Three Ganoderma Species From Lombok in Inhibition Growth of Candida albicans and Cryptoccocus neoformans

Hidayat

Sukiman

Hidayati

et al. 2020

JoSSEd

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“…Jamur ini juga sudah digunakan cukup lama sebagai obat untuk berbagai macam penyakit. Hasil penelitian ini sejalan dengan hasil penelitian Kumar et al (2018) yang menunjukkan bahwa Ganoderma lucidum memiliki aktivitas antifungal terhadap Candida albicans, Aspergillus flavus, A. Fumigates dan Crytococcus neoformans.…”

Section: Aktivitas Antimikroba Ekstrak Etanol Tiga Spesies Ganodermaunclassified

“…Dari semua hasil diatas, diketahui bahwa ketiga spesies Ganoderma positif mengandung senyawa-senyawa antimikroba berupa yaitu terpenoid, flavanoid, tannin, alkaloid dan steroid (Muhsin et al, 2011dan Ede et al, 2012Kumar et al, 2018). Gowrie et al, (2014) melaporkan bahwa Ganoderma lucidum mengandung alkaloid, karbohidrat, saponin, protein, asam amino, fitosterol, lemak, triterpenoid, flavonoid, senyawa fenolik dan tanin yang dapat digunakan sebagai antiinflamasi, antibakteri, antikanker dan antioksidan.…”

Section: Aktivitas Antimikroba Ekstrak Etanol Tiga Spesies Ganodermaunclassified

Perbandingan Aktivitas Antimikroba Ekstrak Etanol dari Tiga Spesies Ganoderma Asal Pulau Lombok

Faturrahman

Sukiman

Suryadi

et al. 2022

jstl

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The use of antibiotics is one of the most important ways to deal with the spread and treatment of pathogenic microbial infections. The search for new antibiotic sources continues to be carried out to anticipate the emergence of microbial resistance. One of the natural resources that has the potential as an antimicrobial source is a member of the macrofungi of the Genus Ganoderma. The purpose of this study was to evaluate the antimicrobial performance of the ethanol extracts of Ganoderma lucidum, G. applanatum dan Ganorderma sp. against fungi (Candida albicans dan Cryptococcus neoformans), gram positive bacteria (Bacillus cereus dan Staphylococcus aureus) and gram negative bacteria (Escherichia coli dan Shigella sp.). Macrofungi samples were taken from the forest area of Nature Tourism Park (TWA) Gunung Tunak, TWA Kerandangan, TWA Suranadi, TWA Nuraksa Sesaot, TWA Lemor and Pusuk forest. The stages of the method performed are sample collection, sample preparation, extraction, and testing of antimicrobial activity using the well difusion method. The ethanol extract concentrations for testing were 20%, 40%, 60% and 80%. The results showed that the three Ganoderma species had anti-fungal and antibacterial activity and that different levels of concentration had an effect on inhibition. The size of the inhibition zone is directly proportional to the higher the extract concentration. The antimicrobial activity of the ethanol extract of G. lucidum was higher when compared to G. applanatum and Ganoderma sp. both against fungi (Candida albicans and Cryptococcus neoformans) as well as against gram-positive and gram-negative test bacteria. In addition, G. applanatum showed very weak inhibition against both groups of tested bacteria. Key words: candidiasis; cryptococcosis; comorbid infections; macerations; pathogens

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Optimization of Growth Conditions and Biological Activities of Nepalese Ganoderma lucidum Strain Philippine

Subedi

Basnet

Panday

et al. 2021

Advances in Pharmacological and Pharmaceutical Sciences

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Ganoderma lucidum has been extensively studied for its valuable medicinal importance. In this study, the artificial cultivation of G. lucidum strain Philippine in different culture media, including sawdust substrate, was performed and optimized on the Potato Dextrose Agar (PDA) media. Phytochemical, antibacterial, and antioxidant analyses were performed and compared between the ethanol extracts prepared from two different cultures (fruit from synthetic log culture and mycelia from PDA media culture). Both the 200 mg/mL and 100 mg/mL concentrations of extracts inhibited all the tested bacteria, and the results were promising than the corresponding control using antibiotics. The fruit extract showed higher antioxidant potential (150.6 ± 56.92 mg ascorbic acid equivalent/g extract) than mycelial extract (144.28 ± 81.72 mg ascorbic acid equivalent/g extract). The results indicate that fruiting bodies of G. lucidum cultivated in a complex dust medium possess higher antioxidant properties than mycelia culture, which can be further explored for therapeutic applications.

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Phytochemical analysis and antifungal activity of Ganoderma lucidum

Cited by 4 publications

References 0 publications

Effectiveness of Ethanol Extract among Three Ganoderma Species From Lombok in Inhibition Growth of Candida albicans and Cryptoccocus neoformans

Effectiveness of Ethanol Extract among Three Ganoderma Species From Lombok in Inhibition Growth of Candida albicans and Cryptoccocus neoformans

Perbandingan Aktivitas Antimikroba Ekstrak Etanol dari Tiga Spesies Ganoderma Asal Pulau Lombok

Optimization of Growth Conditions and Biological Activities of Nepalese Ganoderma lucidum Strain Philippine

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