Phytochemical and Antimicrobial Potency of the Aqueous and Methanol Leaf Extracts of Icacina senegalensis

Background: The root of Icacina senegalensis is used for the treatment of malaria and related conditions in southeastern Nigeria. Methods: To establish its efficacy, the ethanolic root bark extract was investigated as antiplasmodial agent against Plasmodium berghei in mice. A 4-day suppressive test and the curative effect against established infection models of antiplasmodial studies were used. Results: The root bark extract of I. senegalensis (50, 100, and 200 mg/kg) exhibited a significant (p < 0.05) dosedependent activity against the parasite based on suppressive and curative study. The antimalarial effect of I. senegalensis is compared with that of chloroquine (10 mg/kg), the standard drug. The ethanolic root bark extract also prolonged the survival time of infected mice. Conclusions:The results showed that the root bark extract possesses a potential antiplasmodial activity, which can be exploited for the possible development of new antimalarial agent.

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Antidiarrheal and antimicrobial activities of the ethanol extract from the Icacina senegalensis root bark

Akuodor

Nwobodo

Megwas

et al. 2017

Journal of Basic and Clinical Physiology and Pharmacology

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Phytochemical and Antimicrobial Potency of the Aqueous and Methanol Leaf Extracts of Icacina senegalensis

Cited by 4 publications

References 7 publications

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Inhibition of bacterial growth using false yam (Icacina oliviformis) extract as an additive in liquid soap

Antiplasmodial activity of the ethanolic root bark extract of Icacina senegalensis in mice infected by Plasmodium berghei

Antidiarrheal and antimicrobial activities of the ethanol extract from the Icacina senegalensis root bark

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