Phytochemical and multi-biological characterization of two Cynara scolymus L. varieties: A glance into their potential large scale cultivation and valorization as bio-functional ingredients

Luca, Simon Vlad; Kulinowski, Łukasz; Cristina, Ciobanu; Zengin, Gökhan; Czerwińska, Monika E.; Granica, Sebastian; Xiao, Jianbo; Skalicka‐Woźniak, Krystyna; Trifan, Anca

doi:10.1016/j.indcrop.2022.114623

Cited by 14 publications

(13 citation statements)

References 35 publications

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“…All experiments for the determination of flavonoids’ content in vegetal extracts were done in duplicate. The quantification of total flavonoids was realized by spectrophotometric method based on the complexation reaction between flavonoids with aluminum chloride [ 19 , 20 ]. Briefly, 2% aqueous solution of aluminum chloride (1 mL) was added to the sample of vegetal extract (1 mL) and the mixture was incubated for 15 min at room temperature.…”

Section: Methodsmentioning

confidence: 99%

“…The determination was performed on the bases of the method described by Grochowski [ 20 ], on which we made small changes. Therefore, 50 µL of sample was added to 150 µL of 2,2-diphenyl-1-picrylhydrazyl (DPPH) 0.004% methanol solution.…”

Section: Methodsmentioning

confidence: 99%

“…The determinations where performed based on Grochowski’s method [ 20 ] with minor changes. ABTS• + was generated by mixing 7 mM 2,2′-azino-bis(3-ethylbenzothiazoline) 6-sulfonic acid (ABTS) solution with 2.45 mM potassium persulfate (1:1, v / v ).…”

Section: Methodsmentioning

confidence: 99%

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Antioxidants from Galium verum as Ingredients for the Design of New Dermatocosmetic Products

Turcov

Barna

Trifan

et al. 2022

Plants

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The aim of this study was to use plant extracts from spontaneous flora of Moldova (Rediu-Iasi area, Romania) as polyphenols and flavonoids source in order to obtain new dermato-cosmetic formulas to prevent the actions of oxidative stress on skin. Plant extracts (from raw and dried Galium verum sp.) were obtained by: cold classical maceration (M), heat reflux extraction (HTE) and ultrasound assisted extraction (UAE). The extracts were characterized by spectrophotometric method (for polyphenols and flavonoids content and for DPPH antioxidant activity evaluation). In order to evaluate the combating and/or attenuating effects of oxidative stress on skin, the study was continued with the elaboration of emulsions that incorporate one of these extracts. The emulsions were preliminarily characterized by determining the stability over time. The obtained results encourage research in the direction of deeper characterization of these emulsions to determine the microbiological stability and dermatological tests performed on the skin treated with these new products.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Antioxidants from Galium verum as Ingredients for the Design of New Dermatocosmetic Products

Turcov

Barna

Trifan

et al. 2022

Plants

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“…Neutrophils play a significant role in the initiation, progression, and resolution of the inflammatory response in the human body. Biofunctional ingredients endowed with both antioxidant and anti-inflammatory properties were prompted to reduce the risks of modern lifestyle diseases [ 61 , 62 ]. Considering that the A. campestris subsp.…”

Section: Resultsmentioning

confidence: 99%

Exploring the Artemisia Genus: An Insight into the Phytochemical and Multi-Biological Potential of A. campestris subsp. lednicensis (Spreng.) Greuter & Raab-Straube

Trifan

Czerwińska

Mardari³

et al. 2022

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The Artemisia L. genus includes over five hundred species with great economic and medicinal properties. Our study aimed to provide a comprehensive metabolite and bioactivity profile of Artemisia campestris subsp. lednicensis (Spreng.) Greuter & Raab-Straube collected from north-eastern Romania. Liquid chromatography with tandem high-resolution mass spectrometry (LC-HRMS/MS) analysis of different polarity extracts obtained from the aerial parts led to the identification of twelve flavonoids, three phenolic acids, two sesquiterpene lactones, two fatty acids, one coumarin, and one lignan. The antioxidant and enzyme inhibitory properties were shown in the DPPH (0.71–213.68 mg TE/g) and ABTS (20.57–356.35 mg TE/g) radical scavenging, CUPRAC (38.56–311.21 mg TE/g), FRAP (121.68–202.34 mg TE/g), chelating (12.88–22.25 mg EDTAE/g), phosphomolybdenum (0.92–2.11 mmol TE/g), anti-acetylcholinesterase (0.15–3.64 mg GALAE/g), anti-butyrylcholinesterase (0–3.18 mg GALAE/g), anti-amylase (0.05–0.38 mmol ACAE/g), anti-glucosidase (0.43–2.21 mmol ACAE/g), and anti-tyrosinase (18.62–48.60 mg KAE/g) assays. At 100 μg/mL, Artemisia extracts downregulated the secretion of tumor necrosis factor (TNF)-α in a lipopolysaccharide (LPS)-stimulated human neutrophil model (29.05–53.08% of LPS+ control). Finally, the Artemisia samples showed moderate to weak activity (minimum inhibitory concentration (MIC) > 625 mg/L) against the seventeen tested microbial strains (bacteria, yeasts, and dermatophytes). Overall, our study shows that A. campestris subsp. lednicensis is a promising source of bioactives with putative use as food, pharmaceutical and cosmetic ingredients.

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“…Phenolic profiles of different C. cardunculus genotypes show significant differences, but apigenin and caffeoylquinic acid derivatives were generally the main compounds in all the samples. Genotype influence has also been observed in relation to antioxidant activity [ 16 , 17 , 18 ]. Investigations performed on infusion, decoction, and hydroalcoholic extracts of artichoke leaves revealed different concentrations of phenolic compounds and differences in antioxidant activity [ 13 , 19 , 20 ]…”

Section: Introductionmentioning

confidence: 99%

Metabolite Profiling of “Green” Extracts of Cynara cardunculus subsp. scolymus, Cultivar “Carciofo di Paestum” PGI by 1H NMR and HRMS-Based Metabolomics

et al. 2022

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Globe artichoke (Cynara cardunculus L. var. scolymus (L.), is a perennial plant widely cultivated in the Mediterranean area, known for its edible part named capitula or heads. Its functional properties are related to its high levels of polyphenolic compounds and inulin. “Carciofo di Paestum”, an Italian traditional cultivar, is a labeled PGI (Protected Geographical Indication) product of the Campania region, representing an important economic resource. So far, a few chemical investigations were performed on this cultivar, mainly focused on the analysis of methanol extracts. Due to the increasing use of food supplements, in this study, a comprehensive analysis of green extracts of Carciofo di Paestum” PGI heads was performed. EtOH, EtOH: H2O (80:20, 70:30, 60:40) extracts, as well as infusions and decoctions prepared according to Pharmacopeia XII were analyzed by LC-ESI/QExactive/MS/MS. A total of 17 compounds corresponding to caffeoylquinic acid derivatives, phenolics, flavonoids, and terpenoids were identified. The extracts were further submitted to NMR analysis to highlight the occurrence of primary metabolites. Both LCMS and NMR data were analyzed by Principal Component Analysis (PCA), showing significant differences among the extraction methods. Moreover, 5-caffeoylquinic acid and 1,5-dicaffeoylquinic acid were quantified in the extracts by LC-ESI/QTrap/MS/MS using the Multiple Reaction Monitoring (MRM) method. Furthermore, the phenolic content, antioxidant activity, and α-glucosidase inhibitory activity of C. cardunculus var. scolymus “Carciofo di Paestum” extracts were evaluated.

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Phytochemical and multi-biological characterization of two Cynara scolymus L. varieties: A glance into their potential large scale cultivation and valorization as bio-functional ingredients

Cited by 14 publications

References 35 publications

Antioxidants from Galium verum as Ingredients for the Design of New Dermatocosmetic Products

Antioxidants from Galium verum as Ingredients for the Design of New Dermatocosmetic Products

Exploring the Artemisia Genus: An Insight into the Phytochemical and Multi-Biological Potential of A. campestris subsp. lednicensis (Spreng.) Greuter & Raab-Straube

Metabolite Profiling of “Green” Extracts of Cynara cardunculus subsp. scolymus, Cultivar “Carciofo di Paestum” PGI by 1H NMR and HRMS-Based Metabolomics

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