Phytochemical and pharmacological screening of Sargassium vulgare from Suez Canal, Egypt

Shreadah, Mohamed A.; Moneam, Nehad M Abd El; Al-Assar, Samy A; Nabil-Adam, Asmaa

doi:10.1007/s10068-018-0323-3

Cited by 26 publications

(23 citation statements)

References 33 publications

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“…Marine algae are important and valuable sources of structurally diverse biomaterials having antioxidant, anti-inflammatory, anti-coagulant, and anti-thrombotic activities amongst others [4,5,6]. Because free radicals resulted from oxidative stress have important effect in inflammatory reactions process and also in carcinogenesis, the marine algal natural bioactive compounds have been representing potential for use in different area and applications such as anti-cancer, antioxidant and anti-inflammatory drugs candidates.…”

Section: Introductionmentioning

confidence: 99%

Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries

Nabil-Adam

Shreadah

2021

Bioscience Reports

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Background: The liver and kidney inflammation due to bacterial infection is one of the most common pathological problems leading to tissue damage or disease. In many liver and kidney disorders, which represent serious global health burden with a high economic cost, oxidative stress-related inflammation and apoptosis are important pathogenic components, finally resulting in acute liver and/or kidney failure. Erythropoietin and its analogues are well known to influence the interaction between apoptosis and inflammation in liver and kidney. Objective: The aim of this study is to investigate and clarify the effect of G. Oblongata red algae on lipopolysaccharides (LPS)-induced acute liver and kidney injury of mice with endotoxemia and associated molecular mechanism from inflammation, apoptosis and oxidative stress levels. Results: The current study cleared out that treatment of rats with the G. Oblongata extract prior to LPS injection significantly lowered serum cytokines, including NF-κB, MPO and LPO, and improved liver apoptosis through suppressing protein tyrosine kinase signaling pathway, and that may be due to antibacterial activity as well antioxidant capacity of G. Oblongata extract. Conclusion: The current study was cleared out the possibility of administration of G. Oblongata red algae as a multi products source for biotechnological, medical, nutraceutical and pharmaceutical applications due to highly antioxidant and anti-inflammatory capacities even although more investigations are required for separating, purifying and characterizing these bioactive compounds.

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Section: Introductionmentioning

confidence: 99%

Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries

Nabil-Adam

Shreadah

2021

Bioscience Reports

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“…However, some species belonging to the subgenus Sargassum can also be found in subtropical areas, such as S. patens, S. wightii, S. vulgare, S. subrepandum , and S . swartzii [23,37,38,46,50,55,56]. The differentiation between tropical and subtropical samples is based on the thorough evaluation of the sampling location or coordinates information provided in each study.…”

Section: The Potency Of Tropical Sargassum As An Anti-inflammatorymentioning

confidence: 99%

Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

et al. 2019

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Sargassum is recognized both empirically and scientifically as a potential anti-inflammatory agent. Inflammation is an important response in the body that helps to overcome various challenges to body homeostasis such as microbial infections, tissue stress, and certain injuries. Excessive and uncontrolled inflammatory conditions can affect the pathogenesis of various diseases. This review aims to explore the potential of Sargassum's anti-inflammatory activity, not only in crude extracts but also in sulfated polysaccharides and purified compounds. The tropical region has a promising availability of Sargassum biomass because its climate allows for the optimal growth of seaweed throughout the year. This is important for its commercial utilization as functional ingredients for both food and non-food applications. To the best of our knowledge, studies related to Sargassum's anti-inflammatory activity are still dominated by subtropical species. Studies on tropical Sargassum are mainly focused on the polysaccharides group, though there are some other potentially bioactive compounds such as polyphenols, terpenoids, fucoxanthin, fatty acids and their derivatives, typical polar lipids, and other groups. Information on the modulation mechanism of Sargassum's bioactive compounds on the inflammatory response is also discussed here, but specific mechanisms related to the interaction between bioactive compounds and targets in cells still need to be further studied.

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“…Activities of 2,4-Imidazolidinedione, 5-[3,4-bis [(trimethylsilyl) oxy]phenyl]-3-methyl-5-phenyl-1-(trimethylsilyl)-and á-D-Galactopyranoside, methyl2,3bis-O-(trimethylsilyl)-,cyclic butylboronate were not proven. However, reports have confirmed their presence in medicinal plants [35] and seaweeds [36].…”

Section: Journal Of Food and Nutrition Researchmentioning

confidence: 99%

Establishing Gerger (<i>Eruca sativa</i>) Leaves as Functional Food by GC-MS and <i>In-vitro</i> Anti-lipid Peroxidation Assays

Bratty¹,

Thangavel²,

Shar³

et al. 2020

JFNR

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Conventional food that safeguards against chronic illnesses is known as a functional food. Establishing functional foods starts with phytoconstituent analysis and in-vitro characterization of health benefits. Eruca sativa, popularly known as gerger or jarjeer in Saudi Arabia, is an annual edible shrub cultivated worldwide. Gerger leaves are consumed raw in salads and have additional health benefits. This study investigated the phytochemical profile of aqueous decoction of gerger leaves of the Saudi origin by GC-MS assay. We also performed in-vitro anti-lipid peroxidation and total antioxidant capacity assays using gerger decoction. Twenty-seven chemical compounds belonging to seven classes constituted the gerger decoction: organic siloxanes (39.75%), organic silyl esters (18.28%), phenolics (17.87%), aromatic and aliphatic esters (10.48%), terpenoids (7.09%), heterocycles (3.83%), and sulfur compounds (2.70%). This study reported the presence of compounds mentioned above for the first time in gerger leaves. The decoction method was efficient in the extraction of heat-stable terpenoids like astaxanthin (2.23%), cilonasterol (1.48%), ingol-12-acetate (0.4%), and phytol (2.98%). The in-vitro anti-lipid peroxidation study demonstrated the ability of gerger decoction to inhibit hepatic lipid peroxidation in a significantly dose-dependent (150 to 400 μg/ml) manner compared to quercetin. A dose of 400 μg/ml of gerger decoction resulted in 68.46 ± 0.01% inhibition of oxidation of hepatic lipids. The total antioxidant capacity of gerger leaves reported as the IC 50 of the decoction was 217.90 ± 2.2 μg/ml and also statistically significant. The in-vitro models suggested the antioxidant mechanism of gerger was by hydrogen atom transfer and reduction of metal ions. The study substantiated that gerger is a functional food besides established the phytochemical profile contributing to the antioxidant activity. Given that the gerger decoction has a high silicon content and antioxidants, attempt to determine the bioavailability and to identify the molecular targets are essential to overcome bone disorders and oxidative stress.

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Phytochemical and pharmacological screening of Sargassium vulgare from Suez Canal, Egypt

Cited by 26 publications

References 33 publications

Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries

Red algae natural products for prevention of lipopolysaccharides (LPS)-induced liver and kidney inflammation and injuries

Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

Establishing Gerger (<i>Eruca sativa</i>) Leaves as Functional Food by GC-MS and <i>In-vitro</i> Anti-lipid Peroxidation Assays

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