Phytochemical constituents of Cardamine diphylla

Abstract

From the methanol extract of the Cardamine diphylla rhizome, methylethyl-(1), 2-methylbutyl-(2), 3-methylpentyl-(4), 3-indolylmethyl-(5), 1-methoxy-3-indolylmethyl-(6), 4-methoxy-3-indolylmethyl-(7) glucosinolates, and desulfo-2-methylbutylglucosinolate (3) were isolated. The structure elucidation of the compounds was performed by spectroscopic methods. The toxicity on brine shrimp larvae of the methanol extract of the C. diphylla rhizome was evaluated. In addition, the free-radical-scavenging activity of the crude extract was carried out by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay.

Cardamine sp. – A Review on Its Chemical and Biological Profiles

“…The half-maximal scavenging concentration, SC 50 , of the MeOH crude extract of C. diphylla rhizomes, in the DPPH assay, was 766 AE 3 mg/ml [25]. The extract did not seem to exhibit strong free-radical scavenging capabilities compared to ascorbic acid with a SC 50 value of 7 AE 2 mg/ml [25].…”

“…Several concentrations (10, 100, and 1000 ppm) of the MeOH crude extract of C. diphylla rhizomes did not show any toxicity on brine shrimp larvae Artemia salina L. [25]. Brine Shrimp Lethality Test.…”

“…These GLs were also present throughout the rest of the plant. Recently, 2, 5, 9, 16, (3-methylpentyl)GL (17), and [(1methoxy-1H-indol-3-yl)methyl]GL (18) have been isolated from the MeOH extract of C. diphylla rhizome [25]. Recently, 2, 5, 9, 16, (3-methylpentyl)GL (17), and [(1methoxy-1H-indol-3-yl)methyl]GL (18) have been isolated from the MeOH extract of C. diphylla rhizome [25].…”

“…More recently, Agerbirk et al found a number of desulfoGLs originating from 1 -3,5, 9, 10, 13, 15, 17, 22, [3-(hydroxymethyl)pentyl]GL(25), an unidentified isomer of 25, and [(4-methoxyphenyl)methyl]GL(26) in the upper leaf of the flowering shoot of C. pratensis[26]. Furthermore, the authors determined the presence of the desulfoGLs of 2, 3, 9, 10, 13, 22, and 26 in the rosette leaf, as well as 1, 2,5,9,10,13,15,17,18,22, and 26 in the roots.…”

“…Furthermore, the authors determined the presence of the desulfoGLs of 2, 3, 9, 10, 13, 22, and 26 in the rosette leaf, as well as 1, 2,5,9,10,13,15,17,18,22, and 26 in the roots. In addition, commercially obtained C. pratensis contained 1) 5,9,17,18,22,25, and an unidentified isomer of 25 in the rosette leaf; 2) 5,9,17,18,22,25, an unidentified isomer of 25, and [(1,4-dimethoxy-1H-indol-3-yl)methyl]GL(27) in the roots; 3) 9, 17, 18, 25, and an unidentified isomer of 25 in the seeds[26].Finally, one unidentified GL was detected, by PC, in the seed extract of Cardamine rivularis Schur[11].2.1.2. Other Alkaloids.…”