Phytochemical Investigation of the Flowers of Punica granatum.

Ali, Mazhar; Sharma, Nimisha

doi:10.1002/chin.200648207

Cited by 5 publications

(7 citation statements)

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“…PGF has been reported for the management of diabetes in Unani and Chinese medicine (Ali & Sharma 2006). It was confirmed, previously, that most of compounds (actitannins) isolated from the crude extract of P. granatum showed a non-specific enzyme inhibition in vitro except EA which has a specific a-glucosidase inhibition (Li et al 2014).…”

Section: Resultsmentioning

confidence: 77%

“…Isolation of antidiabetic principles from the fruit rinds of P. granatum was also reported (Jain et al 2012). Its flowering part has been recommended in Unani literature as a remedy for diabetes (Ali & Sharma 2006). The methanol extract (PGFMe) of P. granatum flowers demonstrated a potent inhibitory effect on a-glucosidase and improved postprandial hyperglycemia in type 2 diabetes (Li et al 2005).…”

Section: Please Scroll Down For Articlementioning

confidence: 99%

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Triterpenes as uncompetitive inhibitors of α-glucosidase from flowers of Punica granatum L.

Dine

Qiong

Kandil

et al. 2014

Natural Product Research

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The α-glucosidase and maltase inhibitory effects of Punica granatum L. flowers (PGF) were investigated. The methanol extract (PGFMe), n-hexane extract (PGFH), chloroform extract (PGFC) and the remaining water fraction (PGFW) were assayed for their α-glucosidase and maltase inhibitory effects. PGFW showed potent α-glucosidase inhibition with IC₅₀ of 0.8 μg/mL followed by PGFMe (IC₅₀ of 4.0 μg/mL) then PGFC (IC₅₀ of 5.21 μg/mL) in comparison to acarbose (0.9 μM). Due to its selectivity towards α-glucosidase, PGFC was subjected to bioactivity-guided isolation of its main active constituents. Five known compounds (1-5) were identified as β-sitosterol (1), oleanolic acid (2), ursolic acid (3), p-coumaric acid (4) and apigenin (5). Ursolic and oleanolic acids showed potent α-glucosidase inhibition (IC₅₀ of 39.0 and 35.0 μM, respectively), while they did not show significant maltase inhibition. Kinetic study using the double Lineweaver-Burk plot revealed that ursolic acid uncompetitively inhibited α-glucosidase in comparison with acarbose as a competitive inhibitor.

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Section: Resultsmentioning

confidence: 77%

Section: Please Scroll Down For Articlementioning

confidence: 99%

Triterpenes as uncompetitive inhibitors of α-glucosidase from flowers of Punica granatum L.

Dine

Qiong

Kandil

et al. 2014

Natural Product Research

View full text Add to dashboard Cite

show abstract

“…15 17 The anti-inflammatory effect of pomegranate may be attributed to its considerable immune regulatory activity over macrophage and T and B lymphocyte subsets (Ross et al). 4 In vivo study conducted by Grindwit et al in 2003 18 tested the effects of combined extracts from Centella asiatica, commonly known as Asiatic pennywort, and Pomegranate pericap on periodontal wound healing following scaling and root planing. The placement was done subgingivally after scaling and root planing.…”

Section: Pomegranate Mouthrinsementioning

confidence: 99%

“…The powdered flower buds are being used in bronchitis (Ross et al 2001). 3 Flower juice is recommended as a gargle for sore throat, in leukorrhea, hemorrhages and ulcers of the uterus and rectum (Ali et al 2006). 4 The root bark and stem bark of the plant are used as an astringent and anthelmintic specification against tapeworms.…”

Section: Introductionmentioning

confidence: 99%

Hidden Secrets of ‘Punica Granatum’ Use and Its Effects on Oral Health: A Short Review

Rajan¹,

Ravi²,

Suresh³

et al. 2013

JOFR

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The interest in evaluating therapeutic effects of plants has increased dramatically with more and more people inclining toward alternative medicine for their health care needs as they are effective, nontoxic, economical and usually have no sideeffects. Pomegranate is one such fruit/ plant which is beneficial with added effect on oral health.This plant source of polyphenols has antioxidant properties, meaning they help protect cells from damage and may lower the inflammation in the body. Apart from this various other components of the pomegranate plant such as flowers are rich source flavonoids. Peel extracts have been demonstrated to have antibacterial and antifungal activity due to the presence of hydrolysable tannins and polyphenols. The stem part is known to have astringent and antihelminthic properties and the leaves have been used for conjunctivitis.Thus, the purpose of this review is to summarize the therapeutic benefits of various extracts derived from the pomegranate plant and its benefits on oral health.

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“…Flowers of the P. granatum contains different tannins such as ellagic acid and gallic acid, [27] 1, 2-di-O-galloyl-4, 6-O-(S)hexahydroxydiphenyl b-D-glucopyranoside, pomegranatate [28] as well as different flavonoids such as apigenin, punicaflavone etc. [29] Besides, the flower also contains different triterpenoids: ursolic acid, maslinic acid and asiatic acid. [30] The observed antihyperlipidemic activity of the flower extract of Punica granatum may be due to the presence of the above mentioned flavonoids, tannins and triterpenoids as previously it has been reported that flavonoids [31] , tannins [8] and terpenoids [32] possess antihyperlipidemic activity.…”

Section: Biochemical Estimations Of Lipid Profilementioning

confidence: 99%

Anti hyperlipidemic Activity of Flowers of Punica granatum in Poloxamer-407 Induced Hyperlipidemic Mice Model

Sarker

Mahmud

Saha

et al. 2012

Pharmacognosy Journal

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Pomegranate is an important medicinal plant containing versatile bioactive compounds and traditionally was used in the treatment of different diseases. The ripe fruit is tonic, astringent, laxative and diuretic, used in brain diseases, chest troubles, bronchitis and earache. Bark and fruit rind are administered orally to prevent dysentery, diarrhea, piles, bronchitis, biliousness and as an anthelmintic. [2] The dried flowers, known as Gulnar, are efficaceous to treat hematuria, hemoptysis, diarrhea, dysentery, bronchitis, nasal hemorrhage. [3] Pomegranate flowers have been prescribed in Unani and Ayurvedic medicines for the treatment of diabetes. [4] It has been demonstrated that flower extract shows hypoglycemic activity in normal and alloxan-induced diabetic animals. [5] Flower juice is recommended as a gargle for sore throat, oral and throat inflammation, in leucorrhea, hemorrhage and ulcers of the uterus and rectus. [3] Some studies have reported that both the pomegranate flowers and fruit extracts exhibited high activity on lowering

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Phytochemical Investigation of the Flowers of Punica granatum.

Abstract: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Cited by 5 publications

References 0 publications

Triterpenes as uncompetitive inhibitors of α-glucosidase from flowers of Punica granatum L.

Triterpenes as uncompetitive inhibitors of α-glucosidase from flowers of Punica granatum L.

Hidden Secrets of ‘Punica Granatum’ Use and Its Effects on Oral Health: A Short Review

Anti hyperlipidemic Activity of Flowers of Punica granatum in Poloxamer-407 Induced Hyperlipidemic Mice Model

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