Phytochemical Profile, Antioxidant and Cytotoxic Activities of the Carob Tree (Ceratonia siliqua L.) Germ Flour Extracts

Custódio, Luísa; Escapa, Ana Luisa; Fernandes, Eliana; Fajardo, Alba; Aligué, Rosa; Alberício, Fernando; Neng, Nuno R.; Nogueira, J.M.F.; Romano, Anabela

doi:10.1007/s11130-011-0214-8

Cited by 72 publications

(48 citation statements)

References 26 publications

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“…siliqua (CS) was one of the most effective extracts in the antioxidant assays performed herein and its coffee extract also exhibited a moderate level of inhibition against the enzymes tested. Although there has been no report on cholinesterase inhibitory activity of this plant so far, several studies (Custódio et al, 2011;Kumazawa et al, 2002) have described a remarkable antioxidant effect of different parts of CS, which is in accordance with our data.…”

Section: Discussionsupporting

confidence: 92%

In vitro prospective effects of various traditional herbal coffees consumed in Anatolia linked to neurodegeneration

Şekeroğlu

Şenol

Orhan

et al. 2012

Food Research International

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Section: Discussionsupporting

confidence: 92%

In vitro prospective effects of various traditional herbal coffees consumed in Anatolia linked to neurodegeneration

Şekeroğlu

Şenol

Orhan

et al. 2012

Food Research International

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“…The use of several methodologies of extraction and different solvents (Korukluoglu, Sahan, Yigit, Tumay Ozer, & Gucer, 2010), the sample origin (Hayes, Allen, Brunton, O'Grady, & Kerry, 2011), and its genetic (Custódio et al, 2011b) contribute to the differences observed in phenolic profile by HPLC test from study to another (Roseiro et al, 2013;Rtibi et al, 2017).…”

Section: Glycation Reaction Induces Modifications Of Protein Second-mentioning

confidence: 99%

Glucose‐mediated protein glycation: Contribution of methanolic extract of Ceratonia siliqua L. in protection and in vitro potential inhibition of acetylcholinesterase

et al. 2019

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Chronic hyperglycemia presents the major etiology of diabetes mellitus and related complications mainly Alzheimer's disease, via the protein glycation and toxic products generated. In the current study, we investigated the eventual protective effect of the methanolic extract of Ceratonia siliqua L. (CsME) against glucose‐mediated glycation in serum bovine albumin. The multi‐stage glycation markers, namely fructosamines and advanced glycation end products (AGEs) levels were monitored along with measurement of thiol groups; moreover, the in vitro acetylcholinesterase (AChE) inhibition potential was carried out. HPLC was also assessed. Rutin was the main phenolic compound found in CsME. CsME showed a good capacity to inhibit AGEs, fructosamines and protected thiol groups against glycation. CsME exhibited a great AChE inhibition activity. In the present study, CsME prevented glucose‐induced protein glycation, it also exhibited a good inhibition of AChE, suggesting its DM complications such as memory troubles related to AD. Practical applications Neurodegenerative disorders ranging from memory troubles to Alzheimer's disease present the most diabetes mellitus complications and mainly attributed to protein glycation process. Currently, there is a strong trend to search for efficient natural sources of glycation and acetylcholinesterase inhibitors to replace the synthetic ones, whose secondary effects were shown. The present article tries to justify scientifically the wide use of Ceratonia siliqua L. in Moroccan folk medicine, demonstrating that the methanolic extract of leaves from this species presents a promising source of new natural compounds inhibiting acetylcholinesterase and acting in vitro against glycation generated compounds. Furthermore, for the first time, Rutin was the main phenolic compound found in this extract, these encouraging results should be coupled with further studies to integrate it in pharmaceutical formulations. As such, this paper should be of interest to a broad readership, including those interested in Biochemistry, Phytochemistry, pharmacology, and neurosciences.

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“…Nowadays, carob seeds have been paid attention on and they have acted an important role economically since they are used as food additives, in pharmaceutical and cosmetic industries. [5][6][7] In vitro antioxidant activities of CP have been examined by Fe +3 reducing, radical scavenging power activity 8 and by oxidation of linoleic acid. 9 Carob seeds are a particularly rich source of complex polymers of flavonoids such as proanthocyanidin, ellagitannin, and gallotannin.…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective Hepatoprotective Potential and Antioxidant Role of Carob Pods (Cerotonia siliqua L.) against Carbon Tetrachloride-induced Toxicity in Rats

Suzek¹,

Çelik²,

Doğan³

2017

IJPER

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Objective: The aims of current study are the evaluation of the protective effect and antioxidant role of carob pods against carbon tetrachloride (CCl 4 )-induced oxidative stress, hepatotoxicity and nephropathy. Material and Methods: The present experiment was designed as I (control), II (0.5 ml/kg CCl 4 ), III (%10 CP), IV (CCl 4 0.5 ml/kg+%10 CP) groups. While rats in group I and III were fed with a diet without CCl 4 , II, and IV groups received twice 0.5 ml/kg/week, where IV group additionally received %10 CP supplementation for 50 days. The protective roles and antioxidant activity of the CP supplementation feed against CCl 4 -induced oxidative stress and toxicity were evaluated by histopathological changes, measuring hepatic and renal damage biomarkers (HRDB), antioxidant defence system constituents (ADSC) and malondialdehyde (MDA) parameters in the erythrocyte, liver, brain, kidney and spleen tissues of rats. Results: According to the results, the biochemical analysis showed a considerable increase in the serum AST (aspartate aminotransferase), ALT (alanin aminotransferase), GGT (gamma glutamyl transpeptidase) and LDH (lactate dehydrogenase) enzymes, creatinine and urea, and decrease in the group II as compared to that of I group. On contrary, such parameters were decreased in IV group as compared to that of group II. In addition, the results showed that CP supplementation diet restored the CCl 4 induced MDA (malondialdehyde) and ADSC towards to control. The hepatoprotection of CP is further substantiated by the almost normal histological findings in IV group against degenerative changes in II group. Protective effects by CP are further substantiated by the almost normal HRDB for kidney and liver in IV treated group as against degenerative changes in the II treated rats. Conclusion: The results indicated that CP could be as an important as diet-derived antioxidants in preventing oxidative damage in the tissues by reducing the MDA or inhibiting the production of CCl 4 -induced free radicals and liver and kidney destruction.

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Phytochemical Profile, Antioxidant and Cytotoxic Activities of the Carob Tree (Ceratonia siliqua L.) Germ Flour Extracts

Cited by 72 publications

References 26 publications

In vitro prospective effects of various traditional herbal coffees consumed in Anatolia linked to neurodegeneration

In vitro prospective effects of various traditional herbal coffees consumed in Anatolia linked to neurodegeneration

Glucose‐mediated protein glycation: Contribution of methanolic extract of Ceratonia siliqua L. in protection and in vitro potential inhibition of acetylcholinesterase

Nephroprotective Hepatoprotective Potential and Antioxidant Role of Carob Pods (Cerotonia siliqua L.) against Carbon Tetrachloride-induced Toxicity in Rats

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