Phytochemical Screening and Anti-Hyperuricemia Activity Test In Vivo of Ethanolic Extract of Shallot (Allium cepa L.) Skin

Abstract

Uric acid is the final product of purine metabolism that will be excreted through urine, feces, and sweat. Excessive production of uric acid can cause hyperuricemia, known as gout. The skin of shallots (Allium cepa L.) is one of the household wastes that are very rarely used by the community. Ethanol extract of shallot skin (EESS) was tested for phytochemical screening and anti-hyperuricemia activity using potassium oxonate. Mice were divided into five groups (Allopurinol, Na-CMC, EESS 200 mg/kg BW, 300 mg/kg BW, and 400 mg/kg BW) and uric acid levels were observed at 2-hour intervals for six hours. Phytochemical screening shows that EESS has potential compounds in the treatment of gout. Tests to reduce uric acid levels showed that EESS has better potential than allopurinol at concentrations of 300 mg/kg BW and 400 mg/kg BW after six hours of induction in reducing uric acid levels.

Determination of Total Phenolic Content, Analysis of Bioactive Compound Components, and Antioxidant Activity of Ethyl Acetate Seri (Muntingia calabura L.) Leaves from North Sumatera Province, Indonesia

“…Phytochemical screening was carried out as the first step in identifying the group of bioactive compounds contained in the ethyl acetate fraction of M. calabura leaves. Phytochemical screening used standard reagents against groups of compounds including flavonoids, alkaloids, saponins, phenolics, tannins, triterpenoids, and steroids [7], [8], [9], [10], [11].…”

Uji Aktivitas Antibakteri Fraksi Etanol Daun Kelor (Moringa oleifera L.) Terhadap Staphylococcus aureus dan Staphylococcus epidermidis

“…Proses pengeringan bertujuan untuk mencegah tumbuhnya bakteri jamur sehingga diperoleh simplisia yang awet dan dapat disimpan dalam jangka waktu yang lama. Tahapan selanjutnya adalah daun yang sudah kering dihaluskan, dan digunakan untuk tahapan selanjutnya (Syahrina et al, 2020).…”