Sofo-sofo leaves are traditional medicinal plants that have been known by the Nias people to cure fever, coughs, diarrhea and antimicrobial infections on the skin surface. The  purpose  of  this  study  was  to determine the antibacterial activity of ethanol extract, n-hexane fraction and ethylacetate fraction Sofo-sofo leaf (Acmella cf) against Propionibacterium acnes and Staphylococcus epidermidis. Simplicia powder was characterized and phytochemical screening was performed. Furthermore, it was isolated using 96% ethanol solvent and fractionated with  n-hexane and ethylacetate to obtain extracts. Then test the antibacterial activity of each extract against Propionibacterium acne and Staphylococcus epidermidis by using a diffusion method disc paper. The research results obtained water content 5.66%, water soluble extract content 27.33%, ethanol soluble extract content 13.61%, total ash  content 14.39%, and  acid insoluble ash content 6.25%. The highest antibacterial activity was given by ethylacetate extract at a concentration of 2% (23.4 ± 0.2) compared to ethanol extract with a concentration of 2% (21.06 ± 0.85) and 2% concentrated n-hexane extract (19.36 ± 0.16) against the Propionibacterium acne bacteria. The highest antibacterial activity was ethyl acetate extract at a concentration of 2% (23.24 ± 0.23), ethanol extract with a concentration of 2% (16.36 ± 1.76) and n-hexane extract at a concentration of 2% (15.36 ± 0 , 11) against Staphylococcus epidermidis bacteria. The  antibacterial activity results were analyzed by the one way ANOVA test method. Based on these results it can be concluded that there are differences between treatment groups, which is indicated by a significant value <0.05.

Studies have shown that approximately two-thirds of the plant species in the world have some medicinal value. Artocarpus lakoocha is a synonym for Artocarpus lacucha and is a plant that can be found in Indonesia. This medicinal plant has been used to treat many diseases. (1) Objective: This article discusses the scientific investigations carried out on A. lacucha, namely the plant’s chemical content, pharmacological activity, and active compounds. (2) Methods: The design of this study was based on an article that was a review of previous research. A search for relevant publications over the past ten years (2012–2022) using data from Pubmed, Proquest, Ebsco, ScienceDirect, and Google Scholar resulted in the discovery of 369 articles. (3) Results: Fifty relevant articles investigate A. lacucha’s substances and their applications in the health field. The presence of secondary metabolites and bioactive compounds has been reported, which is evidence that A. lacucha possesses antidiarrheal, immunostimulant, anticholesterol, and hepatoprotective agents. (4) Conclusions: Mobe (A. lacucha) is a plant native to North Sumatra, Indonesia. This plant is efficacious as an antioxidant, antibacterial, antidiarrheal, anti-inflammatory, analgesic, antinociceptive, schistosomicidal, hepatoprotective, neuroprotective, cytotoxic, antiglycation, and anticholesterol, and can also be used for anti-aging and wound healing. In addition to its various benefits, it turns out that this plant also has many active compounds that are useful to the health sector, especially the pharmaceutical field.

Uric acid is the final product of purine metabolism that will be excreted through urine, feces, and sweat. Excessive production of uric acid can cause hyperuricemia, known as gout. The skin of shallots (Allium cepa L.) is one of the household wastes that are very rarely used by the community. Ethanol extract of shallot skin (EESS) was tested for phytochemical screening and anti-hyperuricemia activity using potassium oxonate. Mice were divided into five groups (Allopurinol, Na-CMC, EESS 200 mg/kg BW, 300 mg/kg BW, and 400 mg/kg BW) and uric acid levels were observed at 2-hour intervals for six hours. Phytochemical screening shows that EESS has potential compounds in the treatment of gout. Tests to reduce uric acid levels showed that EESS has better potential than allopurinol at concentrations of 300 mg/kg BW and 400 mg/kg BW after six hours of induction in reducing uric acid levels.

Kecombrang (Etlingera Elatior Jack.) merupakan tumbuhan dari famili Zingiberaceae secara tradisional biasa digunakan oleh masyarakat Sumatera Utara sebagai bahan masakan, memperbanyak asi serta sebagai obat luka. Kecombrang memiliki kandungan flavonoid, saponin, tanin, dan asam fenolat yang mampu memberikan efek antibakteri. Tujuan penelitian ini untuk uji penyembuhan luka sayat ekstrak etanol buah kecombrang terhadap tikus putih dan mengetahui konsentrasi efektif dari ekstrak etanol kulit buah kecombrang dalam mempercepat penyembuhan luka sayat terhadap tikus putih. Serbuk simplisia buah kecombrang dikarakterisasi dan diskrining fitokimia kemudian diekstraksi secara maserasi dengan etanol 96%. Ekstrak diberikan secara topikal dalam 3 konsentrasi yaitu 8%, 10%, dan 12% dalam bentuk sediaan salep. Ekstrak diujikan terhadap luka sayat sepanjang 2 cm pada punggung tikus putih. Kontrol positif yang digunakan adalah betadine salep 10%, sedangkan kontrol negatif hanya dilukai saja dan diberikan basis. Hasil penelitian menunjukkan bahwa ekstrak etanol kecombrang dapat menyembuhkan luka sayat terhadap tikus putih dan dengan konsentrasi 12% sama efektifnya dengan kontrol positif terhadap penyembuhan luka sayat yakni pada hari ke-10.