Phytochemical study and protective effect of Trigonella foenum graecum (Fenugreek seeds) against carbon tetrachloride-induced toxicity in liver and kidney of male rat

Mbarki, Sakhria; Alimi, Hichem; Bouzenna, Hafsia; Elfeki, Abdelfettah; Hfaïedh, Najla

doi:10.1016/j.biopha.2016.12.078

Cited by 51 publications

(26 citation statements)

References 52 publications

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“…RQS showed better improvement than YQS as it might possess higher antioxidants (TPC, TC, and TA) than YQS after 6 days of germination. These findings coincide with the results of Mbarki et al [ 54 ], who reported the protective effect of fenugreek seeds against CCl 4 -toxicity in kidneys through polyphenol and flavonoid content, which prevented the production of free radicals.…”

Section: Discussionsupporting

confidence: 92%

Phenolic Profile, Antioxidant Activity, and Ameliorating Efficacy of Chenopodium quinoa Sprouts against CCl4-Induced Oxidative Stress in Rats

et al. 2020

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Quinoa (Chenopodium quinoa) is classified as one of the pseudo-cereal grains rich in both macronutrients and micronutrients. This study tracks changes in the polyphenol composition of red quinoa (RQ) and yellow quinoa (YQ) seeds during germination. The antioxidant bioactivity of raw and germinated seed was also determined in vitro. Phenolic acids and their derivatives and flavonoids were identified by using HPLC-DAD and quantified after 0, 3, and 6 days of germination. Subsequently, the extracts of 6-day-old quinoa sprouts were prepared to biologically evaluate their functional properties against CCl4-induced oxidative stress in rats. The results indicated that antioxidant activity (AOA) of total phenolic compounds (TPC), and flavonoids significantly increased in RQ and YQ sprouts during germination up to 9 days. RQ sprouts exhibited stronger bioactive compound diversity than YQ sprouts as observed in HPLC analysis. Among the 11 and 8 quantified polyphenols, ferulic acid and quercetin were predominant phenolic acid and flavonoid in RQ and YQ sprouts, respectively. After 6 days of germination, 16 and 8 polyphenols were detected and quantified in RQ and YQ sprouts, respectively. Interestingly, the treatment of rats at a dose of 30 mg of Gallic acid Equivalent (GAE) kg−1 significantly reduced fasting blood glucose (FBG), alanine aminotransferase (ALT), aspartate aminotransferase AST, and total bilirubin (TIBIL) and improved liver inflammation. Furthermore, RQ and YQ sprouts improved the blood profile by significantly decreasing low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL) and increasing high-density lipoproteins (HDL). Moreover, RQ and YQ sprout extracts significantly reduced malonaldehyde (MDA) and efficiently enhanced the reduced glutathione (GSH) and superoxide dismutase (SOD) activities in oxidative stress-induced rats as compared to CCl4-rats. In conclusion, red quinoa sprouts (RQS) and yellow quinoa sprouts (YQS) provide naturally synthesized polyphenols, possessing superior antioxidant activity, and their ethanolic extracts have promising effects and potential health benefits to counter induced oxidative stress. Incorporating quinoa sprouts as functional food ingredients should be considered and scaling-up its production is beneficial.

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Section: Discussionsupporting

confidence: 92%

Phenolic Profile, Antioxidant Activity, and Ameliorating Efficacy of Chenopodium quinoa Sprouts against CCl4-Induced Oxidative Stress in Rats

et al. 2020

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“…Regarding the protection study, the observed physical and behavioral response of mice to CCl 4 has also been described previously [26]. The hepatic and renal damage of CCl 4 are well documented and the histopathological findings present are comparable to the literature data [3][4][5]. Accordingly, hepatic centrilobular area and the renal proximal tubules are major xenobiotic transformation sites and particularly sensitive to chemical insults, since they contain biotransformation enzymes from the cytochrome P450 family, which mediate the formation of toxic metabolites and reactive intermediates [27,28].…”

Section: Discussionsupporting

confidence: 80%

“…Conventional drugs have limited efficacy and availability, as well as side effects associated with prolonged use [2], highlighting the need for alternative treatments. Many plant extracts and plant-derived compounds are often tested using animal models for their potential in hepato-and nephroprotective activities against hepatotoxic agents such as the well characterized carbon tetrachloride (CCl 4 ) [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Salicornia ramosissima J. Woods seeds affected the normal regenerative function on carbon tetrachloride-induced liver and kidney injury

Ferreira

Pinto

Silva

et al. 2018

Biomedicine & Pharmacotherapy

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The growing importance of Salicornia plants as bioactive agents and health promoters associated with the continuous demand for alternative treatments for liver disorders, has stimulated us to evaluate the renal and hepatic effects of S. ramosissima seeds in mice under normal conditions and exposure to toxic products as carbon tetrachloride (CCl). Thus, histopathological and lipid peroxidation evaluations of the liver and kidneys were performed. Powdered dried seeds of S. ramosissima (SRS) were administered orally for 22 days at a dose of 2000 mg/kg/day to male mice in three different settings: 1) seed effects, 2) protection against CCl acute toxicity (0.2 mL/kg) and 3) regeneration after acute exposure to CCl (0.2 mL/kg), each study being performed with appropriate control animals. Mice treated with SRS per se had slightly enlarged hepatic sinusoids and noticeable renal inflammation. SRS did not show effective protection against mice exposed to CCl and had no positive influence on liver and kidney recovery after CCl administration. These results demonstrated that SRS failed to improve hepato- and nephrotoxicity, in addition to the apparent synergism between CCl and SRS under these experimental conditions. Although the biological mechanisms of S. ramosissima are not fully understood, the evidence suggests further research to elucidate its adverse biological effects.

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“…Its lipid-lowering properties have been attributed to the prevalence of saponin chemicals in the plant. 124,125 This plant has been found to be effective in the management of menopausal symptoms, notably hot flashes and metabolic syndrome, in several trials. There have been no reports of harmful or serious side effects from taking therapeutic amounts of this herb.…”

Section: Trigonella Foenum -Graecum (Fenugreek)mentioning

confidence: 99%

Promising Herbs as Alternatives for Women with Symptoms of Menopause: A Review

Manipriya¹,

Mallika²,

Dixit³

et al. 2021

JDVAT

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Hot flashes, sleep issues, bipolar disorder, decreased libido, weight gain, and impairments in cognitive performance are all common symptoms of menopause. Herbs and alternative therapies are often of great value to people in the management and treatment of the signs and complications of menopause, due to the adverse effects of hormone therapy. The practices and effects of medicinal plants used in the management of menopausal symptoms are thoroughly reviewed in this article. Clinical investigations have recently demonstrated the efficacy of using many plants and herbs to alleviate menopausal symptoms. Some herbs' traditional uses also have been noted. Medicinal herbs have the potential to exhibit an important role in the treatment of menopausal symptoms; however, further research is needed to back up their efficacy in this domain.

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Phytochemical study and protective effect of Trigonella foenum graecum (Fenugreek seeds) against carbon tetrachloride-induced toxicity in liver and kidney of male rat

Cited by 51 publications

References 52 publications

Phenolic Profile, Antioxidant Activity, and Ameliorating Efficacy of Chenopodium quinoa Sprouts against CCl4-Induced Oxidative Stress in Rats

Phenolic Profile, Antioxidant Activity, and Ameliorating Efficacy of Chenopodium quinoa Sprouts against CCl4-Induced Oxidative Stress in Rats

Salicornia ramosissima J. Woods seeds affected the normal regenerative function on carbon tetrachloride-induced liver and kidney injury

Promising Herbs as Alternatives for Women with Symptoms of Menopause: A Review

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