2015
DOI: 10.5935/0100-4042.20150160
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PHYTOCHEMICAL STUDY ON ANTIMICROBIAL AND CYTOTOXIC ACTIVITY OF SPECIMENS OFLeonotis nepetifoliaL. R. (Br)

Abstract: Specimens of Leonotis nepetiflolia were obtained from cultivated and wild environments to verify their influences in chemical composition. Phytochemical analyses were conducted for the ethyl acetate phase obtained by partitioning the crude ethanol extract from the cultivated leaves of L. nepetifolia. In doing so, flavonoid 3',4',5-trimethoxy-6,7-dihidroxyflavone (cirsiliol), a chemotaxonomic marker of the family Lamiaceae, was isolated. The results reveal that all phases and extracts tested exhibited weak to m… Show more

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Cited by 3 publications
(2 citation statements)
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“…The MTT cell viability assay was performed to evaluate the compound’s cytotoxicity. For this purpose, HaCaT cell line (human keratinocytes) cells were used, which are the main cells composing the epithelium of the oral mucosa [ 32 ]. The cells were cultured in DMEM medium containing 10% fetal bovine serum, 100 μg/mL of streptomycin, and 100 U/mL of penicillin, maintained at 37 °C in a humidified atmosphere with 5% CO 2 .…”
Section: Methodsmentioning
confidence: 99%
“…The MTT cell viability assay was performed to evaluate the compound’s cytotoxicity. For this purpose, HaCaT cell line (human keratinocytes) cells were used, which are the main cells composing the epithelium of the oral mucosa [ 32 ]. The cells were cultured in DMEM medium containing 10% fetal bovine serum, 100 μg/mL of streptomycin, and 100 U/mL of penicillin, maintained at 37 °C in a humidified atmosphere with 5% CO 2 .…”
Section: Methodsmentioning
confidence: 99%
“…Leonotis nepetifolia (Family Lamiaceae) with pantropical distribution is known in Brazil as “Cordão de São Francisco” (Cruz et al, 2011). Previous studies carried out with extracts of this species revealed the cytotoxic potential against human tumor cell lines MCF7 (breast), Hep2 (human epithelial type 2), SF295 (human brain), OVCAR8 (ovarian) and HCT116 (human colorectal) (Veerabadran et al, 2013; Oliveira et al, 2016). A previous study carried out by our research group provided the identification that the flavonoid cirsiliol is one of the compounds responsible for the cytotoxic activity observed in this plant (Oliveira et al, 2016).…”
Section: Introductionmentioning
confidence: 91%