Phytochemical test and optimization of transdermal patches of Carica papaya extract: Formulation design of candidate drug for wound healing

Santi, Tahara Dilla; Siregar, Tongku Nizwan; Sutriana, Amalia; ANDINI, RITA; CANDRA, ADITYA

doi:10.13057/biodiv/d230617

Cited by 8 publications

(9 citation statements)

References 28 publications

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“…PA have both antioxidant and antimicrobial action, but there are not many studies on their individual action in TDD, specifically in TP. Most often, they are investigated together with other phenolic compounds, as natural plant extracts, in the transdermal treatment of wound healing as ion gels, nanoemulgels (anti-inflammatory treatments, skin disorders, diabetic gangrene), or microneedles for better TD [ 110 , 146 , 147 , 148 , 149 , 150 , 151 , 152 ].…”

Section: Natural Products From Plants Used In Medical Devicesmentioning

confidence: 99%

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Isopencu,

Covaliu-Mierlă,

Deleanu

2023

Plants

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Transdermal delivery devices and wound dressing materials are constantly improved and upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, and cost effectiveness. Therefore, researchers in the field have shown an increasing interest in using natural compounds as constituents for such systems. Plants, as an important source of so-called “natural products” with an enormous variety and structural diversity that still exceeds the capacity of present-day sciences to define or even discover them, have been part of medicine since ancient times. However, their benefits are just at the beginning of being fully exploited in modern dermal and transdermal delivery systems. Thus, plant-based primary compounds, with or without biological activity, contained in gums and mucilages, traditionally used as gelling and texturing agents in the food industry, are now being explored as valuable and cost-effective natural components in the biomedical field. Their biodegradability, biocompatibility, and non-toxicity compensate for local availability and compositional variations. Also, secondary metabolites, classified based on their chemical structure, are being intensively investigated for their wide pharmacological and toxicological effects. Their impact on medicine is highlighted in detail through the most recent reported studies. Innovative isolation and purification techniques, new drug delivery devices and systems, and advanced evaluation procedures are presented.

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Section: Natural Products From Plants Used In Medical Devicesmentioning

confidence: 99%

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Isopencu,

Covaliu-Mierlă,

Deleanu

2023

Plants

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“…The leaves were air-dried prior to extraction using ethanol. The extraction process was carried out as described previously by Santi et al [11].…”

Section: Plant Materialsmentioning

confidence: 99%

“…The transdermal patches of C. odorata, A. bilimbi, and C. papaya leaves was prepared according to the procedure of Santi et al [11]. The optimum formulation for the transdermal patch used in this study is Trends Sci.…”

Section: Animal and Treatment Protocolmentioning

confidence: 99%

“…Various studies have proved the presence of woundhealing property in these plants using different application route. The previous results of the GC-MS analysis revealed that C. papaya, C. odorata, and A. bilimbi extract contained several compounds which process wound healing activities [11]. However, there is no information available on the in vivo effect of these plants extract using rat model.…”

Section: Introductionmentioning

confidence: 99%

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Wound Healing Activity of Transdermal Patches of Carica Papaya, Chromolaena Odorata, and Averrhoa Bilimbi Leaves on Incision Wounds of Hyperglycemic Rat

Santi,

Siregar,

Sutriana

et al. 2023

Trends Sci

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Transdermal patches have been used for drug delivery to accelerate the wound healing process with minimum negative effect. This study evaluated the wound healing potential of transdermal patches containing Carica papaya, Chromolaena odorata, and Averrhoa bilimbi leaves extract on hyperglycemic rat as a diabetic wound model. For this purpose, a total of 40 Wistar rats aged 2 - 3 months were randomly distributed into 10 groups. The first 5 groups (P1, P2, P3, P4 and P5) consisted of normal rats which received normal dressing, TP Dermafix, TP of C. papaya, TP of C. odorata, and TP of A. bilimbi, respectively. The second 5 groups (P6, P7, P8, P9 and P10) were hyperglycemic rats that received normal dressing, TP Dermafix, TP of C. papaya, TP of C. odorata, and TP of A. bilimbi, respectively. Skin incisions were made perpendicular to the spine in the thickest part of the skin with an incision length of 2 cm and a depth of 0.5 cm. Patches were applied to the incisions according to the test group and replaced every 2 days for a period of 13 days. Wound healing activity was determined by evaluating the Clinical Sign of Inflammation (CSI) score, wound closure, TGF-β1 concentration, and histology of skin tissue. Data were analyzed using oneway analysis of variance (ANOVA). The results showed that for each parameter observed, the rats intervened with transdermal patches loaded with extract leaves had higher healing potential and different from the control group (normal dressing without intervene) both in normal and hyperglycemic rats. This made us concluded that the TP loaded with C. papaya, C. odorata, and A. bilimbi extract leaves have potential as wound healing agents and could be considered as alternate to the synthetic transdermal patches. HIGHLIGHTS The use of drugs-loaded transdermal patches has been widely studied for the treatment of diabetic wounds, however, the potency of one’s containing Carica papaya, Chromolaena odorata, and Averrhoa bilimbi leaf extracts have not been studied. The present study reports the effectiveness of Carica papaya, Chromolaena odorata, and Averrhoa bilimbi impregnated transdermal patches in treating diabetic rat wounds based on CSI score, histological feature of rat skin and TGF- β concentration. GRAPHICAL ABSTRACT

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“…Many studies reported that extract contain on total phenolic compounds and flavonoids had a strong relation with analgesic effect and other bioactive activities especially anti-inflammatory effect [53]. That phytochemical compounds alkaloids and flavonoids may exert the analgesic and antiinflammatory activity via arachidonic acid metabolism pathway [52,54,55].…”

Section: Central Analgesic Assaymentioning

confidence: 99%

Phytochemical Investigation of Algerian Ceratonia siliqua L. Leaves Extract, by Evaluation of Antioxidants, and Analgesic Effects

Madi

MAAMERI²,

SIHEM³

et al. 2022

Egypt. J. Chem.

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The present study reports on the investigation of phenolic compounds and the determination of the biological activities, toxicity and analgesic effect Ceratonia siliqua, phenolic content was spectrophotometrically quantified with the microplate method, while the bioactivities of methanolic and aqueous extracts were assessed by determining of antioxidant activity. The methanolic extract showed high contents of total flavonoids and exhibited the highest in vitro antioxidant potential (DPPH, ABTS, Superoxide, FRAP, CUPRAC, and phenanthrolin). In the acute toxicity, no death was reported in a dose of 1000, and 1500mg /Kg BW, however the dose of 2000mg/kg BW showed many signs of toxicit y, so the DL50 is higher than 2000mg/Kg BW. In analgesic in vivo assay, the methanolic extract showed a very important capacity to reduce pain, whether central or peripheral, with a certain dose-dependent relationship. For the three tests (hot plate, tail flick and acetic acid assay), the effective dose was 500mg/kg and the effective duration was 30min to 1 hour. This study demonstrate interesting in vitro and in vivo effects of carob leaves extracts and suggests that could be used as an alternative to chemical compounds. According to the extracts concentration and nature, it is very interesting to use like a source of natural antioxidants and analgesic compounds that might be more widely used in pharmaceutical industries.

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Phytochemical test and optimization of transdermal patches of Carica papaya extract: Formulation design of candidate drug for wound healing

Cited by 8 publications

References 28 publications

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Wound Healing Activity of Transdermal Patches of Carica Papaya, Chromolaena Odorata, and Averrhoa Bilimbi Leaves on Incision Wounds of Hyperglycemic Rat

Phytochemical Investigation of Algerian Ceratonia siliqua L. Leaves Extract, by Evaluation of Antioxidants, and Analgesic Effects

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