AbstrakTelah dilakukan uji toksisitas akut dan efek antiinflamasi ekstrak metanol dan n-heksana daun pepaya (Carica papaya L). Hasil skrining fitokimia menunjukkan bahwa daun pepaya mengandung senyawa alkaloid, steroid dan flavonoid. Flavonoid dan alkaloid diekstraksi dari ekstrak metanol daun pepaya dan steroid diekstraksi dari ekstrak n-heksana daun pepaya. Uji toksisitas akut ekstrak metanol dan n-heksana daun pepaya telah dilaksanakan pada tikus dengan pemberian dosis sampel tunggal. Tujuan penelitian ini untuk mengamati respon perilaku (profil farmakologi), pertambahan berat badan dan kematian selama 14 hari. Hasil uji toksisitas akut setelah pemberian ekstrak metanol dan n-heksana daun pepaya dosis 250 mg/kgbb, 500 mg/kgbb, dan 1000 mg/kgbb pada tikus menunjukkan tidak ada yang mati dan efek toksis tidak bermakna. Penelitian efek antiinflamasi pada tikus putih yang diinduksi karagenan 1% dan pemberian ekstrak daun pepaya untuk menurunkan volume radang pada kaki tikus. Pengujian dilakukan dengan metode rat hind paw edema atau pembentukan radang buatan pada telapak kaki kiri tikus putih jantan. Perlakuan dilakukan terhadap enam kelompok yaitu kelompok kontrol positif yang diberi indometacin 10 mg/kgbb, kelompok kontrol negatif yang diberi CMC 1% dan kelompok yang diberi ekstrak metanol atau n-heksana daun pepaya dengan dosis 200 mg/kgbb, 400 mg/kgbb. Volume edema diukur setiap setengah jam selama 5 jam dengan menggunakan plestimometer digital. Data dianalisis dengan uji Kruskal-Wallis dilanjutkan dengan uji Mann-Whitney dengan taraf kepercayaan 95%. Hasil penelitian ini menunjukkan ekstrak pepaya dapat menurunkan volume radang pada kaki tikus. AbstractThe acute toxicity test and antiinflammatory effect of methanolic and n-hexane extracts Carica papaya L leaf have been studied. The results of phytochemical screening show that papaya leaf contains alkaloid, steroid, and flavonoid compound. Flavonoid and alkaloid extracted from methanolic extract of papaya leaf and steroid extracted from n-hexane extract of papaya leaf. The acute toxicity test of methanolic and n-hexane extracts Carica papaya L leaf have been studied on rat with giving a single dose of samples. The aim of this work was to investigate the behavioral responses (pharmacological profile), the development of body weight and mortality for 14 days. The results of acute toxicity test after giving dose of 250 mg/kgbw, 500 mg/kgbw and 1000 mg/kgbw of methanolic and n-hexane extracts of leaves of Carica papaya L to males rat showed no animal died and significant toxic effect. In the study antiinflammatory effects in white rat with carragenan induced 1%, and to determine an effective dose of extract papaya to decrease the edema volume of rat foot. The test was done using rat hind paw edema or esthablished an artificial inflammation in left foot of white male rats. The treatments were carried out on six groups, the positive control group was administered with Indomethacin 10 mg/kgbw per oral, the negative control group was administered with CMC 1%, and the e...

Latar Belakang: Hipertensi adalah kelainan sistem sirkulasi darah yang mengakibatkan peningkatan tekanan darah diatas nilai normal atau tekanan darah ≥140/90 mmhg. Faktor resiko hipertensi dibagi menjadi 2 kelompok yaitu yang dapat dirubah seperti merokok, konsumsi garam berlebih, obesitas, kurang aktivitas fisik, dan stress dan tidak dapat diubah (usia, jenis kelamin, dan genetik). Hipertensi dapat menimbulkan beberapa komplikasi seperti penyakit jantung, gagal ginjal, diabetes dan stroke. Penanganan hipertensi meliputi farmakologi dengan obat antihipertensi dan non farmakologi dengan menjalani gaya hidup sehat. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan kejadian hipertensi pada masyarakat di desa Baet Lampuot.Metode: Penelitian kuantitatif dengan pendekatan cross sectional, teknik sampel menggunakan non-probability sampling dengan teknik accidental sampling. Analisa data menggunakan distribusi frekuensi dan chi square analisis.Hasil: Berdasarkan hasil penelitian terdapat hubungan antara umur responden dengan risiko terjadinya hipertensi dengan p value 0,026 dan terdapat hubungan yang signifikan antara jenis kelamin responden dengan risiko terjadinya hipertensi dengan p value 0,024.Kesimpulan: Terdapat hubungan yang signifikan antara usia dan jenis kelamin terhadap kejadian hipertensi di desa Baet Lampuot.Kata Kunci : hipertensi; usia; jenis kelamin ABSTRACTTitle: Factors Associated with the Incidence of Hypertension in Baet Lampuot Village Aceh BesarBackground: Hypertension is a blood circulation system disorder that results in an increase in blood pressure above the normal value or blood pressure of 140/90 mmHg. Risk factors for hypertension are divided into 2 groups, namely modifiable (smoking, excessive salt consumption, obesity, lack of physical activity, and stress) and non-modifiable (age, gender, and genetics). Hypertension can cause several complications such as heart disease, kidney failure, diabetes, and stroke. Handling hypertension includes pharmacology with antihypertensive drugs and non-pharmacological by living a healthy lifestyle. This study aimed to determine the factors associated with the incidence of hypertension in the community in Baet Lampuot village. Methods: Quantitative research with a cross sectional approach, sampling technique using non-probability sampling with accidental sampling technique. Data analysis used frequency distribution and chi square analysis. Results: Based on the results of the study, there was a relationship between the respondent's age and the risk of hypertension with a p value of 0.026 and there was a significant relationship between the sex of the respondent and the risk of hypertension with a p value of 0.024. Conclusion: There is a significant relationship between age and gender on the incidence of hypertension in Baet Lampuot desa village.Keywords: hypertension; age; gender

The purpose of this study is to determine the analysis of factors related to gross motor development in toddlers in the Meureudu Health Center Working Area, Meureudu District, Pidie Jaya Regency in 2022. This research is descriptive analytic with a cross-sectional research design. Data collection is carried out by distributing questionnaires. The population in this study was all toddlers as many as 99 people and a sample of 99 toddlers with a sampling technique, namely Total Sampling. The data analysis used is univariate and bivariate with the statistical test used, namely the Chi-Square test. The results showed that there is a relationship between gross motor development and maternal knowledge (p value 0.002), there is a relationship between gross motor development of parenting (p value 0.001), there is a relationship between gross motor development and nutritional status (p value 0.002), there is a relationship between gross motor development and birth weight (p value 0.007) and there is a relationship between gross motor development and a history of breastfeeding (p value 0.002) gross motor development. It is hoped that toddler mothers will increase knowledge and motivation by digging up information about gross motor development from various sources such as from health workers and books, so that mothers can supervise gross motor development.

Abstract. Santi TD, Siregar TN, Sutriana A, Andini R, Candra A. 2022. Phytochemical test and optimization of transdermal patches of Carica papaya extract: Formulation design of transdermal patch as candidate drug for wound healing. Biodiversitas 23: 2904-2913. Papaya leaves contain metabolite compounds thathave anti-inflammatory and wound-healing properties. This leaf extract as a transdermal patch allows easy application for wound healing. This study aimed to examine the phytochemicals of papaya leaves and determine the formulation of the transdermal patch. This study employed qualitative methods with color testing and quantitative methods with Gas Chromatography-Mass Spectrophotometry (GC-MS) to determine the phytochemical profiles of papaya leaves. The optimization test of patches used Response Surface Methodology with Box-Behnken design on Expert Version 12 software. There were three factors (x) tested in the study, namely PVP, ethyl cellulose, and Ethanol Extract of Papaya Leaves (EECP). There were also three responses (y) investigated, namely thickness, weight, and moisture content. The phytochemical color testingresults revealed the presence of alkaloids, steroid, terpenoid, saponins, flavonoids, phenolic compounds and the GC-MS analysis showed six compounds with the widest areas. From an ANOVA analysist, the p-value was significant (<0.5) while the match value was less significant (p-value >5%). The optimal patch found in this study was the one containing PVP (0.3 mg), ethyl cellulose (0.4 mg), and EECP (0.3 mg). In terms of response values (y), the patch had a ??thickness of 0.25 mm, a weight of 82 mg, and a moisture content of 4.39%.

Latar belakang: Gempa yang terjadi di Pidie Jaya berdampak luas pada masalah kesehatan, kerusakan material dan korban jiwa. Korban gempa menempati tenda-tenda pengungsian yang didirikan pasca gempa terjadi. Kekurangan sandang, pangan sangat dirasakan oleh masyarakat. Peduli gema Pidie Jaya ditunjukkan dengan pemberian bantuan dan pendekatan pada korban. Tujuan:  Untuk memberikan pendekatan PHBS dan menyalurkan bantuan kebutuhan sandang dan pangan korban terdampak gempa. Metode: Pendekatan dan mengedukasi PHBS dilaksanakan di wilayah terparah gempa yaitu desa Kuta Pangwa. Peserta penyuluhan terdiri dari bapak-bapak dan ibu-ibu di tenda-tenda pengungsian. Hasil: Kegiatan yang dilakukan meliputi penyuluhan dan pemberian bantuan. Peserta antusias mendengarkan penyuluhan PHBS. Materi yang disampaikan dengan metode ceramah, dan praktek mencuci tangan pakai sabun dengan baik dan benar. Kegiatan selanjutnya pemberian bantuan berupa minyak, gula, beras, telur, susu, pampers, susu bayi, dan lainnya. Selanjutnya dibagikan juga pakaian baru baik untuk orang dewasa maupun anak-anak. Kesimpulan: Kegiatan ini memberikan manfaat untuk korban gempa berupa pengetahuan tentang cuci tangan pakai sabun. Selain itu, penyerahan bantuan sembako dan lainnya untuk kebutuhan sehari-hari masyarakat.