Phytochemicals and Biogenic Metallic Nanoparticles as Anticancer Agents

Rao, Pasupuleti Visweswara; Nallappan, Devi; Madhavi, K.; Rahman, Shafiqur; Lim, Jun Wei; Gan, Siew Hua

doi:10.1155/2016/3685671

Cited by 144 publications

(81 citation statements)

References 121 publications

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“…AgNPs are a popular choice in disease management because of their specific interaction with and disruption of the mitochondrial respiratory chain. AgNPs disrupt mitochondrial function by inducing the generation of ROS and suppressing ATP synthesis, which lead to DNA damage [92]. AgNPs have been proven to slow the progression of macular degeneration and other optical diseases.…”

Section: Silver Nanoparticlesmentioning

confidence: 99%

Nanotechnology and nanocarrier-based approaches on treatment of degenerative diseases

et al. 2017

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Degenerative diseases are results of deterioration of cells and tissues with aging either by unhealthy lifestyle or normal senescence. The degenerative disease likely affects central nervous system and cardiovascular system to a great extent. Certain medications and therapies have emerged for the treatment of degenerative diseases, but in most cases bearing with poor solubility, lower bioavailability, drug resistance, and incapability to cross the bloodbrain barrier (BBB). Hence, it has to be overcome with conventional treatment system; in this connection, nanotechnology has gained a great deal of interest in recent years. Moreover, nanotechnology and nanocarrier-based approach drug delivery system could revolutionize the treatment of degenerative diseases by faster absorption of drug, targeted interaction at specific site, and its release in a controlled manner into human body with minimal side effects. The core objective of this review is to customize and formulate therapeutically active molecules with specific site of action and without affecting other organs and tissues to obtain effective result in the improvement of quality of health. In addition, the review provides a concise insight into the recent developments and applications of nanotech and nanocarrier-based drug delivery for the treatment of various degenerative diseases.

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Section: Silver Nanoparticlesmentioning

confidence: 99%

Nanotechnology and nanocarrier-based approaches on treatment of degenerative diseases

et al. 2017

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“…Due to its high surface area, it is used as an efficient adsorbent for numerous toxic chemicals and acid gases. Recently, MgO nanoparticles have shown promise for application in tumor treatment and also have considerable potential as an antibacterial agent [19][20][21][22][23][24]. In the present work and in continuity to our previous work [25], we study the effect of starting organic precursors on the crystal size and morphology of nanosized MgO.…”

Section: Introductionmentioning

confidence: 78%

Synthesis of MgO Nanoparticles from Different Organic Precursors; Catalytic Decontamination of Organic Pollutants and Antitumor Activity

Moustafa¹,

Saleh²,

Abdelhami³

2017

J Material Sci Eng

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The present work deals with the synthesis of nanostructured MgO from different organic precursors, by a facile precipitation method as catalysts for the decontamination of Malathion (stimulant of chemical warfare agents) (VX) and orange G as organic pollutants. The as-prepared nanoparticles were obtained by thermal decomposition of the oxalate, tartarate, citrate, succinate, malate, malonate and glycinate precursors at ≈650°C and were characterized by thermal analysis, FTIR, X-ray diffraction, high resolution transmission electron microscope (HRTEM) and absorption spectra. The morphology and crystal sizes were found to be highly affected by the starting organic precursors. The results revealed that the prepared inexpensive magnesium oxides have high potential as catalysts for photo degradation of both Malathion and orange G from water samples. Inhibitory activity against Breast Carcinoma MCF-7 cell line was detected using some selected nanosized MgO and compared to that of Vinblastine as a standard drug.

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“…The plant resources based green synthesis of a number of MNPs including copper (Cu), gold (Au), nickel (Ni), platinum (Pt), titanium (Ti), selenium (Se), silver (Ag), and zinc NPs have already been reported [19,20]. The plant-based MNPs have been shown to possess various activities such as antimicrobial, anticancer, antidiabetic, antiinflammatory, antioxidant, and immunomodulatory [21][22][23][24]. In recent…”

Section: Plant-based Nanomaterialsmentioning

confidence: 99%

Green Synthesis of Plant-Mediated Metal Nanoparticles: The Role of Polyphenols

Ms¹,

Abbas²,

Kormin³

et al. 2019

Asian J Pharm Clin Res

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The use of metal nanoparticles (MNPs) in various fields is increasing day-by-day leading to a genuine concern about the issues related to their environmental and biological safety. The major approaches for the synthesis of NPs include physical and chemical methods which are expensive and hazardous to health in addition to being toxic to the environment. This review highlights the potential of plant extracts to carry out the synthesis of MNPs with a special emphasis on the role of flavonoids in nanosynthesis. This green and clean approach have been actively utilized in recent years as an alternative to conventional hazardous approaches. It has proved as cost-effective, non-toxic, less time and labor consuming, efficient, and eco-friendly method for the synthesis of MNPs with specific biological actions. This review also focuses on the role of polyphenols, including the flavonoids as bioreductants of metal salts for the synthesis of NPs along with their biomedical applications. Various examples of the MNPs, along with their biological actions, have also been summarized.

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Phytochemicals and Biogenic Metallic Nanoparticles as Anticancer Agents

Cited by 144 publications

References 121 publications

Nanotechnology and nanocarrier-based approaches on treatment of degenerative diseases

Nanotechnology and nanocarrier-based approaches on treatment of degenerative diseases

Synthesis of MgO Nanoparticles from Different Organic Precursors; Catalytic Decontamination of Organic Pollutants and Antitumor Activity

Green Synthesis of Plant-Mediated Metal Nanoparticles: The Role of Polyphenols

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