Phytochemistry and Antibacterial Activity of <i>Cynometra Cauliflora</i>

Wahab, Noor Zarina Abd; Badya, Norhidayah; Ibrahim, Nazlina; Kamarudin, Mohd Khairul Amri

doi:10.5958/0976-5506.2019.00795.2

Cited by 5 publications

(11 citation statements)

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“…The presence of tannins, flavonoids, and terpenoids was reported in the aqueous extracts of stem, bark, and leaf [19], as well as in a methanolic extract of C. cauliflora leaf [33]. Cardiac glycosides were present in the different parts of the plant, except on the stem [19].…”

Section: Chemical Compoundsmentioning

confidence: 95%

“…A methanol leaf extract showed significant antioxidant [15,60,62,63]; antibacterial (against Staphylococcus aureus, Escherichia coli, Porphyromonas gingivalis, and methicillinresistant Staphylococcus aureus [33,62,67]); anti-viral (against herpes simplex virus type 1) [71]; anti-diabetic; antidiarrheal (in vivo) [63]; and cytotoxic potentiality against brine shrimp (Artemia salina) and Vero cells [71,72]. An ethanol leaf extract showed anti-inflammatory activity by inhibiting the activities of arachidonate-5-lipoxygenase and hyaluronidase [64].…”

Section: Biological Studiesmentioning

confidence: 99%

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The Genus Cynometra: A Review of Ethnomedicine, Chemical, and Biological Data

Sabiha

Serrano

Hasan

et al. 2022

Plants

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Cynometra L. is a Fabaceae genus that is widely distributed throughout the tropics, consisting of tropical forest trees with ecological and economic importance since they are used as food and herbal medicines by the populations of their natural habitats. Our goal is to provide a review of the research data concerning the potential of this botanical genus as a source of herbal medicines and secondary metabolites that are useful for human health. To that end, scientific databases, including PubMed, Science Direct, ISI Web of Science, Scopus, and Google Scholar, were searched using the following terms: Cynometra, medicine, chemical, biological activity, toxicity, and “AND” as the Boolean connector. Eleven Cynometra species (9.7%) were reported to be used in traditional medicine to treat different ailments. A total of 185 secondary metabolites of various chemical classes, mainly flavonoids and terpenoids, were identified in eight Cynometra species (7.1%). Vitexin was the only flavonoid identified as bioactive in the sequence of bioguided studies on this botanical genus. Ten species (8.8%) were submitted to in vitro and in vivo biological activity assays. The main evaluated activities were in vitro antioxidant, antimicrobial, cytotoxic, and in vivo anti-inflammatory activities, but no human clinical trials or safety data about this genus were found. Cynometra cauliflora and Cynometra ramiflora were the most studied species. The present work confirms the use of Cynometra species as a source of medicinal plants. However, more experimental studies must be conducted to better understand this botanical genus’s usefulness as a source of raw materials for pharmaceutical use.

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Section: Chemical Compoundsmentioning

confidence: 95%

Section: Biological Studiesmentioning

confidence: 99%

The Genus Cynometra: A Review of Ethnomedicine, Chemical, and Biological Data

Sabiha

Serrano

Hasan

et al. 2022

Plants

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“…The minimum inhibitory concentration (MIC) of the M. cajaputi essential was determined by performing MIC using a 96-well microtiter plate. 14 The highest concentration of essential oils used was 0.714% (w/w). For the positive control, 1 mg/L to 512 mg/L chloramphenicol was prepared.…”

Section: Minimum Inhibitory Concentration (Mic)mentioning

confidence: 99%

Evaluation of Antibacterial Activity of Essential Oils of Melaleuca cajuputi Powell

Wahab¹,

Ja’afar²,

Ismail³

2022

J. Pure Appl. Microbiol.

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Melaleuca cajuputi Powell is a tree species belonging to the family Myrtaceae and is widely used in traditional medicine. This study was conducted to investigate the antibacterial activities of essential oils of M. cajuputi Powell. Antibacterial activity was tested against Gram positive and Gram negative bacteria using the agar disc diffusion method. The essential oils of M. cajuputi were found to exert antibacterial activity against all of the tested bacteria, including Staphylococcus aureus, Streptococcus pyogenes, methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae, and Escherichia coli. The zones of inhibition for S. aureus, S. pyogenes, MRSA, E. coli, and K. pneumoniae were 12.7 mm, 10.7 mm, 10.0 mm, 8.7 mm and 9.3 mm respectively, against 0.714% (w/w) of the essential oils. These results highlighted that Gram negative bacteria are less susceptible to the essential oils of M. cajuputi. A large zone of inhibition might be a sign of a leaching antimicrobial agent. These findings suggest that M. cajuputi is a potential natural antibacterial agent.

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“…The formation of soap-like foam layer shows that there was presence of saponin in the extract solution. 12 Test for terpenoid. 10 mg of extract was added to 2 mL of chloroform followed with 3 mL of concentrated sulphuric acid.…”

Section: Phytochemical Screening Test For Alkaloidmentioning

confidence: 99%

Phytochemical Analysis and Antibacterial Activities of Kyllinga nemoralis Extracts against the Growth of some Pathogenic Bacteria

Wahab¹,

Rahman²

2022

J. Pure Appl. Microbiol.

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This study aimed to screen the phytochemical contents and investigate antibacterial activities of the aqueous and methanolic extracts of Kyllinga nemoralis. Extraction was done using the whole plant of K. nemoralis except the root. The phytochemical screening was carried out on both aqueous and methanolic extracts of K. nemoralis. The aqueous extract showed the presence of saponin and high amount of steroid, while the methanolic extract showed high amount of terpenoid and steroid. The antibacterial activities of K. nemoralis extracts were tested against five Gram positive bacteria (Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Streptococcus pyogenes, and Bacillus thuringiensis) and four Gram negative bacteria (Escherichia coli, Shigella sonnei, Salmonella Typhi and Klebsiella pneumoniae). K. nemoralis extracts were subjected to testing of their antibacterial activities by the disk diffusion method. Furthermore, the minimum inhibitory concentrations of the extracts were determined. The results indicate that the aqueous extract of K. nemoralis exhibits more antibacterial activities than the methanolic extract. The aqueous extract of K. nemoralis showed efficacy against S. aureus and MRSA while the methanolic extract of K. nemoralis was found to exert antibacterial activity against MRSA. The results proved the potency of K. nemoralis extracts as natural antibacterial and supported the potential of use in the medication of the diseases caused by the tested bacteria.

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Phytochemistry and Antibacterial Activity of Cynometra Cauliflora

Cited by 5 publications

References 0 publications

The Genus Cynometra: A Review of Ethnomedicine, Chemical, and Biological Data

The Genus Cynometra: A Review of Ethnomedicine, Chemical, and Biological Data

Evaluation of Antibacterial Activity of Essential Oils of Melaleuca cajuputi Powell

Phytochemical Analysis and Antibacterial Activities of Kyllinga nemoralis Extracts against the Growth of some Pathogenic Bacteria

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