Phytochemistry and pharmacology of ornamental gingers, Hedychium coronarium and Alpinia purpurata: a review

Chan, Eric Wei Chiang; Wong, Siu Kuin

doi:10.1016/s2095-4964(15)60208-4

Cited by 69 publications

(44 citation statements)

References 52 publications

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“…Native from Asia and the Pacific [15], Hedychium coronarium (Zingiberaceae family) is an invasive species in Brazil [16]. Popularly known as white garland-lily, butterfly lily, napoleon, narcissus, Olympia, white ginger or "lírio do brejo" (in Brazil), the H. coronarium rhizomes are used as a starch source [17] and in traditional medicine for treatment of inflammation, diabetes, and rheumatic pain, among other uses [15].…”

Section: Introductionmentioning

confidence: 99%

Coronarin D Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Line

et al. 2019

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Glioblastoma (GBM) is the most frequent and highest–grade brain tumor in adults. The prognosis is still poor despite the use of combined therapy involving maximal surgical resection, radiotherapy, and chemotherapy. The development of more efficient drugs without noticeable side effects is urgent. Coronarin D is a diterpene obtained from the rhizome extract of Hedychium coronarium, classified as a labdane with several biological activities, principally anticancer potential. The aim of the present study was to determine the anti–cancer properties of Coronarin D in the glioblastoma cell line and further elucidate the underlying molecular mechanisms. Coronarin D potently suppressed cell viability in glioblastoma U–251 cell line, and also induced G1 arrest by reducing p21 protein and histone H2AX phosphorylation, leading to DNA damage and apoptosis. Further studies showed that Coronarin D increased the production of reactive oxygen species, lead to mitochondrial membrane potential depolarization, and subsequently activated caspases and ERK phosphorylation, major mechanisms involved in apoptosis. To our knowledge, this is the first analysis referring to this compound on the glioma cell line. These findings highlight the antiproliferative activity of Coronarin D against glioblastoma cell line U–251 and provide a basis for further investigation on its antineoplastic activity on brain cancer.

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Section: Introductionmentioning

confidence: 99%

Coronarin D Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Line

et al. 2019

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“…Miswak’s therapeutic efficacy can be increased in many folds in combination with other medicinal herbs hence it should be further investigated. More research work should be conducted in the field of phytochemistry focusing on both in vitro and in vivo analyses and the isolation of bioactive compounds of interest [42]. …”

Section: Discussionmentioning

confidence: 99%

Detection of antibacterial activities of Miswak, Kalonji and Aloe vera against oral pathogens & anti-proliferative activity against cancer cell line

Amjed

Junaid

Jafar

et al. 2017

BMC Complement Altern Med

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Background: Emerging drug resistance and hindrance of treatment is provoking scientists to search new, less expensive medicinally active compounds. Dental diseases caused by oral pathogens are very frequent chronic infections around the world. The medical potentials of a lot of Pakistani local herbs and herbal combinations is relatively unknown, hence attempted to explore. A study was designed to investigate potential role of local medicinal herbs for example Miswak, Kalonji & Aloe vera as antimicrobial, antioxidant and anti-proliferative agents against oral pathogens and cancer cell line.Methods: Medicinal extracts were prepared in solvents of different polarities. Their antimicrobial activity was determined alone and in combination against oral pathogens. Antioxidant activity was evaluated through Catalase and Superoxide dismutase assay and anti-proliferative activity was evaluated through 3-(4, 5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide) assay. Results: Plant extracts alone and in combinations were found significantly effective as antimicrobial agent against standard ATCC strains of C. albicans and S. aureus (P ˂0.001). Especially Miwak extract was found highly significant against fungus. Extracts of Kalonji were found significant in inhibiting growth of HeLa cell lines. Miswak and Kalonji showed significant levels of antioxidant activity. Conclusion:Medicinal herbs Miswak and Kalonji have potential to be used for therapeutic purposes. Results suggested that herbal medicinal composition can be prepared using these extracts after applying scientific standardization methods.

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“…Berdasarkan penelitian etnobotani, spesies Alpinia telah banyak dimanfaatkan sebagai bahan obat-obatan di negara Asia [2]. A. purpurata memiliki aktivitas sebagai antioksidan, antibakteri, larvasida, sitotoksik dan vasodilator [3]. Kandungan metabolit sekunder dalam lengkuas merah adalah flavonoid, alkaloid, tanin, triterpenoid/steroid, dan saponin [4].…”

Section: Pendahuluanunclassified

Triterpenoid dan Nanopartikel Ekstrak n-Heksana dari Rimpang Lengkuas Merah (Alpinia purpurata (Vieill.) K. Schum) Serta Uji Sitotoksisitas dengan BSLT

2017

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Penelitian ini bertujuan untuk mengisolasi senyawa triterpenoid dari rimpang Alpinia purpurata dan fabrikasi nanopartikel ekstrak n-heksana serta membandingkan aktivitas sitotoksik antara nanopartikel dan ekstrak n-heksana. Senyawa triterpenoid diisolasi dari ekstrak n-heksana menggunakan kromatografi kolom gravitasi dan KLT Preparatif. Metode yang digunakan untuk fabrikasi ekstrak n-heksana menjadi nanopartikel adalah sonikasi dengan menggunakan prosesor ultrasonik. Penentuan aktivitas sitotoksik ekstrak n-heksana menggunakan metode BSLT (Brine Shrimp Lethality Test). Hasil analisis GC-MS isolat triterpenoid memiliki berat molekul sebesar 426 g/mol diduga merupakan senyawa Lupeol. Berdasarkan analisis ukuran partikel menggunakan instrumen PSA, nanopartikel ekstrak n-heksana memiliki ukuran 278,0 nm. Hasil uji sitotoksisitas ekstrak n-heksana dan nanopartikel ekstrak n-heksana menghasilkan LC50 berturut-turut sebesar 109,668 ppm dan 86,783 ppm. Ekstrak n-heksana dalam bentuk nanopartikel dapat meningkatkan bioaktivitas.

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Phytochemistry and pharmacology of ornamental gingers, Hedychium coronarium and Alpinia purpurata: a review

Cited by 69 publications

References 52 publications

Coronarin D Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Line

Coronarin D Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Line

Detection of antibacterial activities of Miswak, Kalonji and Aloe vera against oral pathogens & anti-proliferative activity against cancer cell line

Triterpenoid dan Nanopartikel Ekstrak n-Heksana dari Rimpang Lengkuas Merah (Alpinia purpurata (Vieill.) K. Schum) Serta Uji Sitotoksisitas dengan BSLT

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