Phytoconstituents as photoprotective novel cosmetic formulations

Saraf, Shailendra; Kaur, Chanchal Deep

doi:10.4103/0973-7847.65319

Cited by 116 publications

(73 citation statements)

References 40 publications

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“…Exposure to UV radiation can suppress the immune system, but GSP prevented this suppression in mice fed a diet containing GSP. Treatment of cells with GSP increased tumor cell death in a model used to study tumor promotion in skin cells [50].…”

Section: Phytochemicals Skin Cancer and Rosmentioning

confidence: 98%

Oxidative Stress and Skin Cancer: An Overview

Narendhirakannan

Hannah

2012

Ind J Clin Biochem

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Skin is the largest body organ that serves as an important environmental interface providing a protective envelope that is crucial for homeostasis. On the other hand, it is a major target for toxic insult by a broad spectrum of physical and chemical agents that are capable of altering its structure and function. There are a large number of dietary contaminants and drugs can manifest their toxicity in skin. These environmental toxicants or their metabolites are inherent oxidants and/or directly or indirectly drive the production of a variety of reactive oxidants also known as reactive oxygen species. These are short-lived entities that are continuously generated at low levels during the course of normal aerobic metabolism. These are believed to activate proliferative and cell survival signaling that can alter apoptotic pathways that may be involved in the pathogenesis of a number of skin disorders. The skin possesses an array of antioxidant defense mechanisms that interact with toxicants to obviate their deleterious effect. The ''antioxidant power'' of a food is an expression of its capability both to defend the human organism from the action of the free radicals and to prevent degenerative disorders. Plants like olive trees have their own built-in protection against the oxidative damage of the sun, and these built-in protectors function as cell protectors in our own body. Although many antioxidants have shown substantive efficacy in cell culture systems and in animal models of oxidant injury, unequivocal confirmation of their beneficial effects in human populations has proven elusive.

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Section: Phytochemicals Skin Cancer and Rosmentioning

confidence: 98%

Oxidative Stress and Skin Cancer: An Overview

Narendhirakannan

Hannah

2012

Ind J Clin Biochem

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“…In addition to this, Phosphatidylcholine is also hepatoprotective and so provides a synergistic effect for liver protection [9].…”

Section: D)mentioning

confidence: 99%

Phytosome as a Novel Biomedicine: A Microencapsulated Drug Delivery System

Pawar¹,

Bhangale²

2015

J Bioanal Biomed

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The term "phyto" means plant while "some" means cell-like. Phytosome is a novel emerging technique applied to phyto-pharmaceutical which contains phytoconstituents of herbal extract surrounds and bound by lipid. Most of bioactive constituents of phyto-medicine are water soluble compounds like flavonoids. Because of water solubility and lipophilic outer layer, phytosome shows better absorption, hence produces better bioavailability than the conventional herbal extracts. Because of their improved pharmacological and pharmacokinetic properties, phytosome are used to treat acute and chronic liver diseases and therapeutically used as dietary supplements. The current review highlights key findings of recent research work conducted on phytosomes with our own viewpoints which can give the new directions and advancements to herbal dosage forms and the technical aspects of phyto-phospholipid formulations to face the future challenges.

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“…The edema score was assigned as: 0= none; 1= slight; 2= well defined; 3= moderate; and 4= severe. 32 After the treated skin visual examination, all animals were sacrificed and the skin was excised and studied histopathologically using hemotoxylin and eosin staining. The criteria included degeneration, necrosis, congestion, inflammation, and edema.…”

Section: Primary Skin Irritation Studiesmentioning

confidence: 99%

“…More moist skin is more pliable, and retains its moisturizing effect. 32 The efficacy of the sunscreen creams with respect to UVR protection property is expressed by the SPF values. SPF values of SC1 and SC2 creams revealed the importance of physical sunscreen agents (nano-TiO 2 and nano-ZnO) in order to achieve high UVR protection.…”

mentioning

confidence: 99%

Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity

Shetty

Venuvanka

Jagani

et al. 2015

IJN

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The objective of present work was to develop novel sunscreen creams containing polymeric nanoparticles (NPs) of morin. Polymeric NPs containing morin were prepared and optimized. The creams containing morin NPs were also prepared and evaluated. Optimized NPs exhibited particle size of 90.6 nm and zeta potential of −31 mV. The entrapment efficiency of morin, within the polymeric NPs, was found to be low (12.27%). Fourier transformed infrared spectroscopy and differential scanning calorimetry studies revealed no interaction between morin and excipients. Transmission electron microscopy and atomic force microscopy revealed that the NPs were spherical in shape with approximately 100 nm diameter. Optimized NPs showed excellent in vitro free radical scavenging activity. Skin permeation and deposition of morin from its NPs was higher than its plain form. Different sunscreen creams (SC1–SC8) were formulated by incorporating morin NPs along with nano zinc oxide and nano titanium dioxide. SC5 and SC8 creams showed excellent sun protection factor values (≈40). In vitro and in vivo skin permeation studies of sunscreen creams containing morin NPs indicated excellent deposition of morin within the skin. Morin NPs and optimized cream formulations (SC5 and SC8) did not exhibit cytotoxicity in Vero and HaCaT cells. Optimized sunscreen creams showed excellent dermal safety. SC5 and SC8 creams demonstrated exceptional in vivo antioxidant effect (estimation of catalase, superoxide dismutase, and glutathione) in UV radiation-exposed rats. The optimized sunscreen creams confirmed outstanding UV radiation protection as well as antioxidant properties.

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Phytoconstituents as photoprotective novel cosmetic formulations

Cited by 116 publications

References 40 publications

Oxidative Stress and Skin Cancer: An Overview

Oxidative Stress and Skin Cancer: An Overview

Phytosome as a Novel Biomedicine: A Microencapsulated Drug Delivery System

Development and evaluation of sunscreen creams containing morin-encapsulated nanoparticles for enhanced UV radiation protection and antioxidant activity

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