Phytopharmacological evaluation of ethanol extract of Sida cordifolia L. roots

Momin, Mohammad Abdul Motalib; Bellah, Sm Faysal; Rahman, Sarder Mohammad Raussel; Rahman, Ahmed A.; Murshid, G.M.M.; Emran, Talha Bin

doi:10.1016/s2221-1691(14)60202-1

Cited by 53 publications

(34 citation statements)

References 34 publications

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“…The phytopharmacological evaluation of ethanolic extract of S. cordifolia roots found reducing sugars, alkaloids, saponins, and steroids. 46 The plant also possesses flavonol glycosides. 47 Two bioactive flavones, 5,7-dihydroxy-3-isoprenyl flavones and 5-hydroxy-3-isoprenyl flavones isolated from the aerial parts of S. cordifolia, showed analgesic and anti-inflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

Nrf2-mediated antioxidant response by ethanolic extract ofSida cordifoliaprovides protection against alcohol-induced oxidative stress in liver by upregulation of glutathione metabolism

2014

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Objective The study aimed to evaluate the antioxidant property of ethanolic extract of Sida cordifolia (SAE) on alcohol-induced oxidative stress and to elucidate its mechanism of action. Methods Male albino rats of the Sprague-Dawley strain were grouped into four: (1) control, (2) alcohol (4 g/kg body weight), (3) SAE (50 mg/100 g body weight), and (4) alcohol (4 g/kg body weight) + SAE (50 mg/100 g body weight). Alcohol and SAE were given orally each day by gastric intubation. The duration of treatment was 90 days. Results The activities of toxicity markers in liver and serum increased significantly in alcohol-treated rats and to a lesser extent in the group administered SAE + alcohol. The activity of alcohol dehydrogenase and the reactive oxygen species level were increased significantly in alcohol-treated rats but attenuated in the SAE co-administered group. Oxidative stress was increased in alcohol-treated rats as evidenced by the lowered activities of antioxidant enzymes, decreased level of reduced glutathione (GSH), increased lipid peroxidation products, and decreased expression of γ-glutamyl cysteine synthase in liver. The co-administration of SAE with alcohol almost reversed these changes. The activity of glutathione-S-transferase and translocation of Nrf2 from cytosol to nucleus in the liver was increased in both the alcohol and alcohol + SAE groups, but the maximum changes were observed in the latter group. Discussion The SAE most likely elicits its antioxidant potential by reducing oxidative stress, enhancing the translocation of Nrf2 to nucleus and thereby regulating glutathione metabolism, leading to enhanced GSH content.

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Section: Discussionmentioning

confidence: 99%

Nrf2-mediated antioxidant response by ethanolic extract ofSida cordifoliaprovides protection against alcohol-induced oxidative stress in liver by upregulation of glutathione metabolism

2014

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“…A cut off period of 30 sec (Franzotti et al, 2000), was observed to avoid damage to the paw. Reaction time was recorded when animals licked their fore or hind paws, or jumped at 0, 30, 60 and 90, 120, 180 and 240 min after oral administration of the samples (Momin et al, 2014). The animals of test groups received test samples at the doses of 100 and 200 mg/kg body weight.…”

Section: Hot Plate Methodsmentioning

confidence: 99%

In vivo analgesic, anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic fruits extract from Daemonorops robusta Warb

Uddin¹,

Ahmed²,

Kabir³

et al. 2017

J App Pharm Sci

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“…In DPPH scavenging assay the IC 50 value was found to be 50µg/mL which was not comparable to the standard ascorbic acid 10 . Although a number of plants traditionally been used by the people of Purulia district for the treatment of different diseases e.g.…”

Section: Introductionmentioning

confidence: 77%

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2017

IJPSR

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ABSTRACT:The objectives of the present study were to evaluate the preliminary phytochemical analysis (quantitative and qualitative) and DPPH antioxidant activity of two traditionally important plants occurring at Purulia district of West Bengal in India. Qualitative analysis of phytochemicals (flavonoid, alkaloid, terpenoids, saponins, phenol and carbohydrate) and quantitative analysis of total phenolics and flavonoids were done by using suitable test protocols available in the literature. Antioxidant activity was studied through DPPH assay. Qualitative phytotochemical analysis revealed that the methanolic extract exhibit richness in flavonoids, alkaloids, terpenoids, saponins, phenols and carbohydrates in comparison with aqueous extract. Total phenol and flavonoid content shows highest concentration in methanolic part of A. aspera (1.129mg GA EQ/gm, 3.22mg QEQ/gm) and lowest concentration in aqueous part of S cordifolia (.348mg GA EQ/gm, .324mg QEQ/gm). EC 50 values of the two plants were 48.06µg/ml in A. aspera and 52.43µg/ml in S. cordifolia. The results conclude that there is positive correlation between total phenol content and DPPH antioxidant activity. The plants could serve as potential source of natural antioxidants.

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Phytopharmacological evaluation of ethanol extract of Sida cordifolia L. roots

Abstract: The obtained results provide a support for the use of this plant in traditional medicine but further pharmacological studies are required.

Cited by 53 publications

References 34 publications

Nrf2-mediated antioxidant response by ethanolic extract ofSida cordifoliaprovides protection against alcohol-induced oxidative stress in liver by upregulation of glutathione metabolism

Nrf2-mediated antioxidant response by ethanolic extract ofSida cordifoliaprovides protection against alcohol-induced oxidative stress in liver by upregulation of glutathione metabolism

In vivo analgesic, anti-inflammatory potential in Swiss albino mice and in vitro thrombolytic activity of hydroalcoholic fruits extract from Daemonorops robusta Warb

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